Tolerability and benefit of a tetramethoxyluteolin-containing skin lotion

Abstract

As many as 40% of people have sensitive skin and at least half of them suffer from pruritus associated with allergies, atopic dermatitis (AD), chronic urticaria (CU), cutaneous mastocytosis (CM), and psoriasis. Unfortunately, the available topical formulations contain antihistamines that are often not as effective as those containing corticosteroids. Certain natural flavonoids have anti-inflammatory actions. We recently reported that the natural flavonoid tetramethoxyluteolin has potent antiallergic and anti-inflammatory actions in vitro and in vivo. This flavonoid was formulated in a skin lotion along with olive fruit extract and was first tested for tolerability in 25 patients with mastocytosis or mast cell activation syndrome and very sensitive skin who reported back through a questionnaire. The skin lotion was then used by eight patients, four with AD and four with psoriasis, who had not received any topical treatment for at least 2 months, twice daily for 2 weeks. The use of this tetramethoxyluteolin formulation resulted in significant improvement of the skin lesions and could be useful adjuvant treatment for allergic and inflammatory skin conditions.

SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors

“…We have shown that methoxyluteolin is a more potent inhibitor of human mast cells (57) and human keratinocytes (37) compared with luteolin, and that therapeutic doses can be achieved in vivo (Table S1). Flavonoids (58), particularly luteolin (59) and methoxyluteolin (60), are considered safe. The time course of the key signaling steps of stimulation with the combination of IL-33 and SP led to JNK kinase activation within the first 5 min, whereas IKβ-α became active within the first hour, and both remained active over the next 4 h of stimulation.…”

TNF stimulates IL‐6, CXCL8 and VEGF secretion from human keratinocytes via activation of mTOR, inhibited by tetramethoxyluteolin

“…However, methlut is also metabolically more stable than lut . A methlut‐containing skin lotion is now commercially available and showed benefit in mild psoriasis …”

Reply to Fattori et al.: Action of SP and IL-33 on mast cells

“…The ability of the natural flavonoid tetramethoxyluteolin to inhibit mast cells stimulated by either IL-33, substance P, or their combination (2), which we report in our paper, has now been validated in a pilot clinical trial: a skin lotion containing tetramethoxyluteolin was shown to reduce skin inflammation in patients with atopic dermatitis and psoriasis (10).…”