Tolerability of Isradipine in the Treatment of Mild-to-Moderate Hypertension in General Practice

Hermans, Linda; Bogaert, M. G.; Dumanski, Jan P.; Rorive, G; Six, Roland; Bara, L.; Lanssiers, P.; Keyser, P De; Westelinck, K. J.

doi:10.1097/00005344-199200001-00010

Cited by 7 publications

(1 citation statement)

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“…Regarding dosage, we have only tested a standard dose for the two drugs (ISR 5 mg and FOS 20 mg) because some reports show an unimportant difference in the antihypertensive efficacy with higher doses, but significant increase in adverse effects.lT6. 1 3 9 21, 22 Some of the risk factors for cardiovascular morbidity and mortality, in particular high BP, can be affected positively by pharmacologic treahr~ent.~~-*~ Our data show that both oncea-day antihypertensive treatments-FOS and ISR-were effective in lowering BP significantly in patients with mild to moderate essential hypertension, as assessed by noninvasive 24-h ABPM. It has been generally accepted that the new ACE inhibitors and CCBs are almost equivalent as first-line treatment of essential hypertension, particularly for their eficacy, long duration of action, and tolerability.…”

Section: Discussionmentioning

confidence: 72%

Evaluation of antihypertensive effects of once‐a‐day isradipine and fosinopril: A double‐blind crossover study by means of ambulatory blood pressure monitoring

Perticone

Pugliese

Marcantonio

et al. 1995

Clinical Cardiology

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Summary:We compared the efficacy and tolerability of isradipine (ISR) and fosinopril (FOS) once-a-day administration in 17 outpatients, 9 men and 8 women, aged 35-65 years (mean + SD = 58 k 10 years), affected by mild to moderate primary systemic hypertension. The patients were given singleblind placebo for 2 weeks and thereafter, in double-blind, randomized, crossover sequence, ISR (5 mg) and FOS (20 mg), both fur 4 weeks. At the end of each period, patients underwent 24-h noninvasive blood pressure (BP) monitoring by means of an A&D TM 2420 Monitor Model 7, with readings taken every 10 min during the day (from 7 A.M. to 11 P.M.), and every 20 min during the night (from 11 P.M. to 7 A.M. were observed in any patient under either therapy. Both ISR and FOS resulted in very effective decrease in BP; however, FOS proved to be significantly more effective than ISR.

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Section: Discussionmentioning

confidence: 72%