Tolerability of Nasal Delivery of Humidified and Warmed Air at Different Temperatures: A Randomised Double-Blind Pilot Study

Bibby, Susan; Reddy, Sumeet K; Cripps, Terrianne; McKinstry, Steve; Weatherall, Mark; Beasley, Richard; Pilcher, Janine

doi:10.1155/2016/7951272

Cited by 8 publications

(13 citation statements)

References 34 publications

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“…The WHO laboratory work shows that heat at 56ºC kills the SARS coronavirus at around 10,000 units per 15 min. This could pave way for a potential therapeutic prospect of warm steam inhalation/heated humidified air delivery/rhinothermy, which has been traditionally and clinically proven to be potent against viral upper respiratory tract infections [17][18][19].…”

Section: Therapeutic Prospectsmentioning

confidence: 99%

SARS-CoV-2: Current Perspective on Control, Prevention, and Therapeutic Promise

Ikwuka¹,

Nwobodo

Anayehie

et al. 2020

SJMS

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Background: The novel coronavirus disease (COVID-19) outbreak has halted activities throughout the globe because of its rapid spread. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a β-coronavirus first detected in China. SARS-CoV-2 has been implicated to be transmitted via direct contact, fomite, respiratory droplets, and possibly aerosol. The spread of the disease is complicated due to the slow onset of symptoms and asymptomatic infected patients. Methods: This narrative communication summarizes the recent researches sourced using sensitive search strategies to identify COVID-19 current perspectives on the control, prevention, and therapeutic promise. Result: Several strategies and multiple control measures have been implemented around the globe to contain COVID-19. Considering the exponential spread of the pandemic, several scientists and physicians have been racing to discover possible therapeutics and vaccines for COVID-19. There are clinical trials to investigate the vaccine designed to protect against the infection and also to substantiate the claim made for BCG protection against COVID-19. Although, there is currently no universally approved medication to treat SARS-CoV-2, there have been random reports of existing medications ameliorating the infection, and these regimens are still under clinical trial. There is also the potential therapeutic prospect of rhinothermy to fight SARS-CoV-2 judging from its success in fighting upper respiratory tract viral infection. Conclusion: The information provided in this communication gives a reliable intellectual grounding regarding the current perspective on COVID-19 control, progress made in the development of vaccines and therapeutic regimen, and where future research in this area should be focused. Key words: COVID-19; SARS-CoV-2; control; WHO; respiratory; cases; tract

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Section: Therapeutic Prospectsmentioning

confidence: 99%

SARS-CoV-2: Current Perspective on Control, Prevention, and Therapeutic Promise

Ikwuka¹,

Nwobodo

Anayehie

et al. 2020

SJMS

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“…These are similar to observations made in our earlier tolerability of the myAIRVO device in healthy volunteers. 26 In the current study, participants used the myAIRVO 2 device for 2 hours per day on average throughout the 5-day treatment period and for 2.6 hours on the days of use. As instructed, not all participants used the device late in the treatment course once their symptoms had improved.…”

Section: Discussionmentioning

confidence: 99%

“…21 We have reported a tolerability study that found that a high flow nasal cannula device (myAIRVO 2, Fisher & Paykel Healthcare, Auckland, New Zealand) modified to deliver high flow humidified air at 41°C via wide bore nasal cannulae was well tolerated in healthy volunteers. 26 The potential advantage of this device for rhinothermy is that it can deliver a consistent temperature, humidity and flow rate direct into the upper airways. The study reported here is a feasibility study of rhinothermy in the treatment of the common cold that will inform the design of a robust RCT of this treatment.…”

Section: Open Accessmentioning

confidence: 99%

Randomised controlled trial of rhinothermy for treatment of the common cold: a feasibility study

et al. 2018

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ObjectiveTo determine the feasibility of a randomised controlled trial (RCT) of rhinothermy for the common cold.DesignOpen label, randomised, controlled feasibility study.SettingSingle-centre research institute in New Zealand recruiting participants from the community.Participants30 adult participants with symptoms of a common cold, presenting within 48 hours of the onset of symptoms.InterventionsParticipants were randomly assigned 2:1 to receive either 35 L/min of 100% humidified air at 41°C via high flow nasal cannulae, 2 hours per day for up to 5 days (rhinothermy), or vitamin C 250 mg daily for 5 days (control).Primary and secondary outcome measuresThe primary outcome was the proportion of screened candidates who were randomised. Secondary outcomes included: proportion of randomised participants who completed the study; modified Jackson scores from randomisation to 10 days after initiation of randomised regimen; time until feeling ‘a lot better’ compared with study entry; time until resolution of symptoms or symptom score at 10 days postrandomisation; proportion of organisms identified by PCR analysis of nasal swabs taken at baseline; the patterns of use of the rhinothermy device; estimated adherence of the control group; and rhinothermy device tolerability.ResultsIn all 30/79 (38%, 95% CI 27% to 50%) of potential participants screened for eligibility were randomised. Rhinothermy was well tolerated, and all randomised participants completed the study (100%, 95% CI 88% to 100%). The reduction from baseline in the modified Jackson score was greater with rhinothermy compared with control at days 2, 3, 4, 5 and 6, with the maximum difference at day 4 (−6.4, 95% CI −9.4 to −3.3). The substantial clinical benefit threshold for modified Jackson score was a 5-unit change.ConclusionsThis study shows that an RCT of rhinothermy compared with low-dose vitamin C in the treatment of the common cold is feasible.Trial registration numberACTRN12616000470493; Results.

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“…36 Public health students' knowledge will be enhanced if researches are done in Covid-19 quarantine centers to authenticate the suspected prevention regimens of internalized and externalized hot water, frequent gargling, hourly ingestion of hot beverages and especially continuous nasal steam delivery for 30 -60 minutes during the very early stage of the virus infection. 37,16 Limitations of the study This study is based on a small convenient sample, without randomization, and thus results cannot be generalized. The survey instrument was not verified through key witness interviews or focus group to determine clarity of understanding by study participants.…”

Section: Recommendationmentioning

confidence: 99%

“…15 Since respiratory viral pathogens are temperature sensitive, continuous nasal steam delivery for thirty to sixty minutes has the potential to cure URTI or common cold, humanity's most frequent infection unlike steam inhalation which merely relieves the symptom. 16,17 Though the mechanism of action is yet unknown, gargling with fluids e.g tap water, saline water etc is one of the measures long recommended by Japanese health authority to prevent upper respiratory tract infections caused by rhinovirus, coronavirus, influenza virus, pneumococci, streptococci etc. 18 Experience in clinical dentistry reveals the prevailing ignorance surrounding health effects of cold beverages.…”

Section: Introductionmentioning

confidence: 99%

Analysis of public health students’ knowledge on health effects of thermoneutral, hot and cold water

Enemchukwu¹,

Okenu²,

Njoku³

2020

MOJPH

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Water is a very important nutrient with numerous health effects when ingested or applied on the body in thermoneutral, hot or cold forms. These health effects are however often neglected in public health studies, leaving students to access majority of their information from mostly unregulated Internet sources. Objective: To investigate the level of knowledge and sources of information of final year public health students on the health effects of thermoneutral, hot or cold water. Materials and methods: Data were collected using structured self-administered questionnaire. Analysis was performed by simple calculations of percentages. Results: The students' main source of information, at up to 50% was leisure time Internet Googling with social media. The students' highest score of 54% was on knowledge of water as a nutrient, a basic Biology, Health and Nutrition subject. The next high score was 49% on externalized use of water, an area very familiar with the students since they habitually indulged in cold water baths. 44% was recorded for water hydration while the lowest score of 24% was on health effects of ingested water/inhaled steam. The overall knowledge level on health effects of thermoneutral, cold or hot water was 43%. Conclusion: Dependence on leisure time, i.e. unguided Googling and social media tends to corrupt health knowledge. Previous exposure through formal education, guided internet searches and personal experience enhance level of knowledge. There is serious need to guide students early in their careers on how to obtain authentic health information from the internet.

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Tolerability of Nasal Delivery of Humidified and Warmed Air at Different Temperatures: A Randomised Double-Blind Pilot Study

Cited by 8 publications

References 34 publications

SARS-CoV-2: Current Perspective on Control, Prevention, and Therapeutic Promise

SARS-CoV-2: Current Perspective on Control, Prevention, and Therapeutic Promise

Randomised controlled trial of rhinothermy for treatment of the common cold: a feasibility study

Analysis of public health students’ knowledge on health effects of thermoneutral, hot and cold water

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