Tolerability of preparation Inspector Quadro by dogs and cats

Arisov, M. V.; Artemov, V.V.; Belykh, I.P.

doi:10.30896/0042-4846.2018.21.6.46-50

Cited by 3 publications

(3 citation statements)

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“…Одновременное паразитирование у животных паразитов, относящихся к различным типам (Plathelminthes, Nemathelminthes, Artropoda), тре-бует назначение препаратов, обладающих не только антигельминтными, но и инсектоакарицидными свойствами [1]. Многие препараты, обладающие широким спектром действия, часто в качестве действующего вещества содержат ивермектин или моксидектин [6].…”

Section: Introductionunclassified

“…Фипронил, входящий в состав лекарственного препарата, обладает выраженной инсектоакарицидной активностью в отношении преимагинальных и имагинальных фаз развития блох, вшей, власоедов, саркоптоидных, иксодовых и демодекозных клещей. Механизм его действия заключается в блокировании ГАМК-зависимых рецепторов членистоногих, нарушении передачи нервных импульсов, что приводит к параличу и гибели насекомых и клещей [2].…”

Section: Introductionunclassified

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Study of acute toxicity of the drug «Prazitsid®-Complex»

Kuznetsov,

Belova,

Gavrilova

et al. 2024

jour

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Preclinical testing of the new drug «Prazid®-complex», developed by LLC «Apisenna» (Russia, Moscow, Smolenskaya-Sennaya sq., 27, building 1A, apartment 74), containing 102 mg of praziquantel in 1 ml, 5 mg ivermectin, 100 mg of fipronil and excipients were carried out on non-linear laboratory mice purchased from the branch of the National Research Center «Kurchatov Institute» PNPI - PLZh «Rappolovo». The acute toxicity of the drug was determined according to GOST 32644-2014 and «Guidelines for experimental (preclinical) study of new pharmacological substances» (2005)» on 6 mice (3 females and 3 males in each group. To determine the LD50 of the drug, five experimental groups of six animals each (3 males and 3 females) were formed from 30 mice. To calculate the parameters of acute toxicity, we used the method of determining LD50 using probit analysis according to Litchfield and Wilcoxon, which is based on taking into account the mortality of animals from administered doses of the drug under study. The hazard class of the drug was determined according to GOST 12.1.007-76. It was found that the drug «Prazicide®-complex» in doses of 2.0; 3.5; 5.0; 6.5 g/kg causes death in 100% of experimental animals within 24 hours. When the drug is administered at a dose of 0.5 g/kg body weight for 14 days, death is observed in 50% of experimental mice. LD50 of the Prazitsid®-complex drug is 0.5 g/kg body weight. According to the classification (GOST 12.1.007-76), the drug «Prazid®-complex» should be classified as a low-toxic compound (hazard class 3) and used for clinical trials on animals.

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Section: Introductionunclassified

Study of acute toxicity of the drug «Prazitsid®-Complex»

Kuznetsov,

Belova,

Gavrilova

et al. 2024

jour

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“…The mechanism of an allergic reaction development is due to the physicochemical properties of a drug, its dose, method and duration of its administration, as well as the characteristics of the macroorganism to respond to environmental influences by changing their life. Hypersensitivity reactions can manifest themselves in two main types, specifically, an immediate type reaction, associated with humoral immune mechanisms and occurring quickly (15-25 min) after contact with an antigen, and a delayed type reaction, associated with cellular immune mechanisms and developing longer (for 24-48 hours) [15]. The study of new therapeutic agents for allergenicity should contain a set of allergodiagnostic methods necessary in each particular case, which will reliably identify various types of hypersensitivity [1,4].…”

Section: Introductionmentioning

confidence: 99%

Experimental evaluation of allergenic properties of Bisphenol-5

Ahmadullin¹,

Muhammadiev

Валиуллин

2020

BIO Web Conf.

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The paper presents the results of preclinical studies of the allergenic properties of a new drug bisphenol-5, which has pronounced anti-radical activity. An experimental study of the antioxidant was carried out in doses of 2, 5, 20 mg/kg in guinea pigs and rabbits. It was shown that bisphenol-5 is not able to cause a general anaphylaxis reaction (anaphylactic shock). By the method of skin applications, the absence of allergenic effects of the drug in animals was found. During the formulation of conjunctival tests in experimental and control animals, signs of hypersensitivity, both immediate and delayed, were not observed with respect to the test drug. Changes in body temperature, pulse rate, and the number of respiratory movements as a result of clinical studies of the state of the animal organism after applying bisphenol-5 were also not recorded. Thus, the drug Besphenol-5 in the studied doses and under the selected experimental conditions does not have a negative effect on the body of laboratory animals and does not have allergenic properties.

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Tolerability study of Imidacloprid-Pyriproxyfen-Moxidectin-based drugs in dogs and cats

Tochieva

Arisov

2023

Ross. parazitol. ž..

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The purpose of the research is to study tolerance of Imidacloprid-Pyriproxyfen-Moxidectin-based drugs for veterinary use by target animal species.Materials and methods. The research was conducted on 15 clinically healthy outbred cats aged 1–2 years weighing 3–5 kg, 15 clinically healthy outbred kittens aged 7–9 weeks weighing 700–900 g, 15 clinically healthy outbred dogs aged 1–2 years weighing 18–20 kg, and 15 clinically healthy outbred puppies aged 7 weeks up to three months weighing 6–9 kg, in the Kurilovo Experimental Base, the Podolsk Department of the VNIIP – FSC VIEV, in 2021. Combined drugs, Insacar Total S and Insacar Total K (Imidacloprid, Pyriproxyfen and Moxidectin), were used as drips, which was resulted in good absorption of active substances through the skin. The effect of combined Imidacloprid-Pyriproxyfen-Moxidectin-based drugs was evaluated on general condition and behavior, body weight gain dynamics, animal morphological and biochemical blood parameters, and physicochemical urine parameters.Results and discussion. Drugs for veterinary use, Insacar Total K and Insacar Total S, in increased therapeutic doses (twice and five-fold) do not adversely affect the general condition and behavior of cats, kittens, dogs or puppies; no deviations were recorded in morphological and biochemical blood parameters, or physicochemical urine parameters.

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Tolerability of preparation Inspector Quadro by dogs and cats

Cited by 3 publications

References 0 publications

Study of acute toxicity of the drug «Prazitsid®-Complex»

Study of acute toxicity of the drug «Prazitsid®-Complex»

Experimental evaluation of allergenic properties of Bisphenol-5

Tolerability study of Imidacloprid-Pyriproxyfen-Moxidectin-based drugs in dogs and cats

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