Tolerability of Racecadotril in Acute Watery Diarrhoea in Children

Abstract

BACKGROUNDAcute diarrhoea remains a major cause of mortality and morbidity in children due to dehydration, dyselectrolytemia and nutrient loss. Racecadotril is found to be effective in reducing the stool output in acute watery diarrhoea in children through its potent antisecretory effect mediated by enkephalinase inhibition in basolateral membrane of enterocytes and promoting selective chloride absorption through delta receptors and may prove to be beneficial in complications associated with acute watery diarrhoea.