Tolerability to non-endosomal, micron-scale cell penetration probed with magnetic particles

Ruiz-Cánovas, Eugènia; Mendoza, Rosa; Villaverde, Antonio; Corchero, José Luís

doi:10.1016/j.colsurfb.2021.112123

Cited by 1 publication

(1 citation statement)

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“…The ability to produce large quantities of uniform particles with a variety of shapes and complex functionalities has great potential for a wide range of applications. In particular, microparticles decorated with magnetic nanoparticles are of interest for biomedical applications such as drug delivery [27][28][29], hyperthermia [30,31], biosensing [32], magnetomechanical actuation [33] etc. Moreover, magnetic particles can be rotated by an external magnetic field, making them useful as microstirrers [34,35], micromotors [36], and microrheological probes [37].…”

Section: Introductionmentioning

confidence: 99%

Magnetic field directed assembly of magnetic non-spherical microparticles

Piltaver,

Vilfan,

Kostevc

et al. 2024

J. Phys.: Condens. Matter

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This study reports on the fabrication and assembly of anisotropic microparticles as versatile building blocks for directed magnetic assemblies. Although spherical microparticles have received extensive attention, the assembly of non-spherical magnetic microparticles remains underexplored. Herein, we present a fabrication approach that utilizes photolithography and soft lithography to create prism-shaped magnetic microparticles. In order to investigate their assembly, a switching rotating magnetic field was employed. To support our experimental findings, a numerical model which takes into account the magnetic dipole moments induced by the field of other particles was developed. This model helps in understanding the forces and torques governing particle behaviour during assembly. Simulations were conducted using the numerical model to complement our experimental findings. In the two particle experiments, attractive magnetic interactions led to various configurations depending on initial positions. For three particles, a tip-to-tip configuration suggested closed or stable ring-like structures. Our work highlights the feasibility of producing highly responsive, non-spherical magnetic microparticles and their potential for assemblies. The versatile fabrication method, coupled with the added degree of freedom conferred by prismatic shapes, opens promising avenues for applications in biology and material science.

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