Tolérance à l’irradiation des tissus sains : les ovaires

Groß, E.; Champetier, C.; Pointreau, Y.; Zaccariotto, A.; Dubergé, T.; Guerder, C.; Ortholan, C.; Chauvet, B.

doi:10.1016/j.canrad.2010.01.011

Cited by 13 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We supposed that ovarian insufficiency plays an important role in the development of these vascular diseases, especially in ischemic stroke. Recently, Gross et al reported the surgical technique of ovarian transposition (moving the ovaries away from the field of irradiation) minimizes the radiation dose and damage to the ovary [19]. In addition, although the “timing hypothesis” holds that estrogens have beneficial effects on young and healthy blood vessels of women, direct evidence showing the benefit of replacement therapy is scarce [20].…”

Section: Discussionmentioning

confidence: 99%

Increased risk of ischemic stroke in cervical cancer patients: a nationwide population-based study

et al. 2013

View full text Add to dashboard Cite

BackgroundIncreased risk of ischemic stroke has been validated for several cancers, but limited study evaluated this risk in cervical cancer patients. Our study aimed to evaluate the risk of ischemic stroke in cervical cancer patients.MethodsThe study analyzed data from the 2003 to 2008 National Health Insurance Research Database (NHIRD) provided by the National Health Research Institutes in Taiwan. Totally, 893 cervical cancer patients after radiotherapy and 1786 appendectomy patients were eligible. The Kaplan-Meier method and the Cox proportional hazards model were used to assess the risk of ischemic stroke.ResultsThe 5-year cumulative risk of ischemic stroke was significantly higher for the cervical cancer group than for the control group (7.8% vs 5.1%; p <0.005). The risk of stroke was higher in younger (age <51 years) than in older (age ≥51 years) cervical cancer patients (HR = 2.73, p = 0.04; HR = 1.37, p = 0.07) and in patients with more than two comorbid risk factors (5 years cumulative stroke rate of two comorbidities: 15% compared to no comorbidities: 4%).ConclusionsThese study demonstrated cervical cancer patients had a higher risk of ischemic stroke than the general population, especially in younger patients. Strategies to reduce this risk should be assessed.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased risk of ischemic stroke in cervical cancer patients: a nationwide population-based study

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The extent of the damage that occurs in the ovary depends on several factors such as age of the patient (the younger is the patient at the time of radiation, the greater is the damage), exposure dose, exposure time and eventually associated chemotherapy [28]. In prepubertal age the gonads are extremely vulnerable to radiations [22, 29]; it is estimated that ≤ 2 Gy of radiation would destroy half of immature oocytes [30], while 25–50 Gy would produce infertility in a third of young women and in almost all women over 40 years of age [31–34] (Table 1).…”

Section: Radiation Therapymentioning

confidence: 99%

Radiations and female fertility

Marci

Mallozzi²,

Benedetto³

et al. 2018

Reprod Biol Endocrinol

View full text Add to dashboard Cite

Hundreds of thousands of young women are diagnosed with cancer each year, and due to recent advances in screening programs, diagnostic methods and treatment options, survival rates have significantly improved. Radiation therapy plays an important role in cancer treatment and in some cases it constitutes the first therapy proposed to the patient. However, ionizing radiations have a gonadotoxic action with long-term effects that include ovarian insufficiency, pubertal arrest and subsequent infertility. Cranial irradiation may lead to disruption of the hypothalamic-pituitary-gonadal axis, with consequent dysregulation of the normal hormonal secretion. The uterus might be damaged by radiotherapy, as well. In fact, exposure to radiation during childhood leads to altered uterine vascularization, decreased uterine volume and elasticity, myometrial fibrosis and necrosis, endometrial atrophy and insufficiency. As radiations have a relevant impact on reproductive potential, fertility preservation procedures should be carried out before and/or during anticancer treatments. Fertility preservation strategies have been employed for some years now and have recently been diversified thanks to advances in reproductive biology. Aim of this paper is to give an overview of the various effects of radiotherapy on female reproductive function and to describe the current fertility preservation options.

show abstract

“…This natural decrease can be aggravated by chemotherapy as well as radiation therapy causing direct DNA damage to follicles. Ovarian tissue is very sensitive to radiation [5]. It was estimated that ≤ 2 Gy will destroy half of immature oocytes [4,6] and 4 Gy produces infertility in a third of young women and in almost all women over 40 years of age [7].…”

Section: Reviewmentioning

confidence: 99%

Modern radiation therapy and potential fertility preservation strategies in patients with cervical cancer undergoing chemoradiation

et al. 2015

View full text Add to dashboard Cite

Young patients with cervical cancer who undergo chemoradiation might be interested in fertility preservation, not only dependent upon the use of a gestational carrier as maybe achieved by the use of ovarian transposition and cryo-conservation of oocytes or ovarian tissue, but may prefer to carry pregnancy to term after cancer treatment. The latter approach is a non-established concept needing both modern radiation therapy approaches as well as modifications -if at all possible- in current recommendations for target volume delineation to spare dose to the unaffected uterus. Future strategies to serve selected patients in this respect should only be conducted in prospective clinical evaluations and are critically discussed in this article.

show abstract

Tolérance à l’irradiation des tissus sains : les ovaires

Cited by 13 publications

References 14 publications

Increased risk of ischemic stroke in cervical cancer patients: a nationwide population-based study

Increased risk of ischemic stroke in cervical cancer patients: a nationwide population-based study

Radiations and female fertility

Modern radiation therapy and potential fertility preservation strategies in patients with cervical cancer undergoing chemoradiation

Contact Info

Product

Resources

About