Tolerance and acceptable daily intake of ethylene dichloride in the chicken diet

Alumot, Eugenia; Meidler, M.; Holstein, P.; Herzberg, M

doi:10.1016/s0015-6264(76)80253-2

Cited by 22 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…are equal to that previously determined for rats (250 ppm and 25 mg/kg body weight respectively) (Alumot et al 1976a). Chickens were fed mash containing fumigant levels of 250 or 500 ppm over a two year period.…”

Section: Ethylene Dichloride and Carbon Tetrachloridesupporting

confidence: 55%

See 1 more Smart Citation

The Effect of Fumigants on Food Quality

Plimmer

1977

Journal of Food Safety

View full text Add to dashboard Cite

Fumigants are used to prevent pest infestations in food and other stored commodities. The quality of the commodity may be affected by fumigant treatment in several ways. Residues of unchanged fumigant may remain in the commodity. Reaction of the individual chemical components of the commodity with the fumigant may alter its chemical or physical properties, thus resulting in changes in flavor, taste, odor, nutritional value or processing qualities. Methyl bromide, ethylene dibromide, ethylene dichloride, carbon tetrachloride, phosphine and ethylene oxide are the major fumigants used for treatment of grains, vegetables and fruits. Their effects on food quality and the significance of residues in treated commodities are reviewed.

show abstract

Section: Ethylene Dichloride and Carbon Tetrachloridesupporting

confidence: 55%

“…For growing chicks and cocks the tolerances and A.D.I. are equal to that previously determined for rats (250 ppm and 25 mg/kg body weight respectively) (Alumot et al 1976a).…”

Section: Ethylene Dichloride and Carbon Tetrachloridementioning

confidence: 51%

The Effect of Fumigants on Food Quality

Plimmer

1977

Journal of Food Safety

View full text Add to dashboard Cite

show abstract

“…Short-term IP doses of 10 mg EDC/kg, daily for five days, rendered male C57BL/6 mice sterile for at least 9 months. Previous reports on the lack of reproductive toxicity utilized drinking water and diet as a route of exposure [8][9][10][11]. It is possible that the concentrations of EDC in the food and water were over estimated due to the high volatility of this compound.…”

Section: Discussionmentioning

confidence: 99%

“…Inhalation studies showed only embryo *Address correspondence to this author at the Department of Environmental Sciences, 1279 Energy, Coast & Environment Bldg., Louisiana State University, Baton Rouge, LA 70803, USA; Tel: (225) 578-1753; Fax: (225) 578-4286; E-mail: Monster77@aol.com toxicity at high doses and no significant reproductive toxicity [8]. Rats and mice exposed to this highly volatile compound in drinking water or in diet showed no effects on fertility [9,10] and lacked remarkable pathology in reproductive tissues [11].…”

Section: Introductionmentioning

confidence: 99%

Ethylene Dichloride Disruption of Fertility in Male Mice

Daigle¹,

Cole²,

Lee³

et al. 2009

TOTOXIJ

View full text Add to dashboard Cite

Ethylene dichloride (EDC) is a high use compound in chemical industry today. Although a potent alkylating agent and carcinogen, EDC has not been associated previously with adverse fertility consequences. Intraperitoneal 5 to 40 mg/kg once a day for five days in C57BL/6 mice rendered males infertile for 6 months and longer. Two of three mice treated with EDC at 5 mg/kg recovered to fertility after a 3 and 5-week sterile period, respectively. Significant testicular pathology was evident within 8 days post treatment with EDC, which progressed to resemble Sertoli Cell-Only syndrome. Although the observed effects on Leydig cell populations were equivocal, a precipitous loss of spermatogonia was evident with increasing time post EDC treatment for mice dosed with either 5 or 10 mg/kg of EDC. These results suggest that intraperitoneal EDC adversely impacts the testes and spermatogenesis in mice.

show abstract

Halogenated One‐Carbon Compounds

Bevan

2023

Patty's Toxicology

View full text Add to dashboard Cite

This chapter reviews the one‐carbon compounds with chlorinated, brominated, or iodinated substituted side groups. At ambient temperatures, methyl chloride and methyl bromide are gases; iodoform and methylene chlorobromide are solids; and the remaining seven chemicals in this chapter are volatile, nonflammable liquids. The nonflammability has been an important property for the uses of these chemicals as solvents. Most, if not all, of the chemicals in this chapter are produced in closed‐system facilities. Three of the chemicals (methyl bromide, carbon tetrachloride, and methylene chlorobromide) are ozone‐depleting substances and are tightly regulated under the Montreal Protocol on Substances that Deplete the Ozone Layer. Thus, these chemicals are restricted to feedstock or intermediate uses where, by definition, it is used and entirely consumed, except for trace quantities, and certain exempt applications. For the other chemicals in this chapter, the primary, if not exclusive, uses are as feedstocks or intermediates in the production of other chemicals, the exception being methyl iodide.

show abstract

Tolerance and acceptable daily intake of ethylene dichloride in the chicken diet

Cited by 22 publications

References 5 publications

The Effect of Fumigants on Food Quality

The Effect of Fumigants on Food Quality

Ethylene Dichloride Disruption of Fertility in Male Mice

Halogenated One‐Carbon Compounds

Contact Info

Product

Resources

About