Tolerance and analgesic efficacy of a new i.v. paracetamol solution in children after inguinal hernia repair

Murat, I.; Baujard, Catherine; Foussat, C.; Guyot, E.; Petel, H.; Rod, B.; Ricard, C.

doi:10.1111/j.1460-9592.2004.01518.x

Cited by 99 publications

(45 citation statements)

References 18 publications

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“…[6] In a clinical trial, comparing the analgesic efficacy of IV paracetamol after inguinal hernia repair in children. [13] Similar to our results, they found that no clinically significant abnormality in vital signs were observed with this new solution of paracetamol. Also, we did not observe any adverse effect of drug during IV administration.…”

Section: Discussionsupporting

confidence: 90%

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Analgesic Efficacy of Intravenous Versus Rectal Acetaminophen After Adeno Tonsillectomy in Children

Bhandari¹,

Mitra²,

Shahi³

et al. 2015

jemds

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INTRODUCTION: Doses of acetaminophen 15mg/ kg intravenous and 40 mg/kg rectally produce similar effect-site concentrations. However, the clinical effectiveness of these routes has not been compared. The aim of this study was to compare the efficacy of analgesia (in terms of duration of analgesia and effect on pain intensity) in children following adenotonsillectomy after acetaminophen either 15 mg/ kg IV or 40 mg/ kg rectally. METHODS: Fifty children, aged between 5 and 14 yrs., undergoing elective adenotonsillectomy were randomly allocated into two groups. Group IV received 15mg/kg intravenous acetaminophen and Group PR received 40mg/kg rectal acetaminophen. Blood pressure, heart rate, respiratory rate and oxygen saturation were continuously monitored. Postoperative pain was assessed by visual analogue scale (VAS) and rescue analgesia provided if scores were 4 or greater. The primary outcome measure was time to first rescue analgesia. RESULTS: The time to first rescue analgesia was significantly longer in children receiving rectal acetaminophen (8.96 ± 3.46) compared with those receiving IV acetaminophen (6.00 ± 1.63) (P-value 0.000). Only one child in IV Group required rescue analgesia within first 6 hours with differences between the groups being most prominent in the period from 6 to 10 hours. Vitals did not show any difference in both groups peri-operatively. Postoperative pain assessment by VAS at various time intervals showed no significant difference between the groups. CONCLUSIONS: Rectal acetaminophen 40 mg/ kg provides longer analgesia for moderately painful procedures when compared with 15 mg/ kg acetaminophen IV. However, efficacy of intravenous paracetamol has no superiority to rectal administration.

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Section: Discussionsupporting

confidence: 90%

“…[11,12,13] However, the optimum route of administration of acetaminophen is unclear, there are few studies directly comparing routes of delivery for actual analgesic effectiveness. [4,14] We chose to compare single doses of acetaminophen 15 mg/kg IV and 40 mg/kg per rectal as these are the often used doses associated with similar plasma levels.…”

mentioning

confidence: 99%

Analgesic Efficacy of Intravenous Versus Rectal Acetaminophen After Adeno Tonsillectomy in Children

Bhandari¹,

Mitra²,

Shahi³

et al. 2015

jemds

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show abstract

“…Assessments using the Smiley scale and VAS were performed separately at rest and in motion. Whenever the intensity of pain increased above 3 on a 10-point scale, a higher stage of the treatment scheme was used [17].…”

Section: Methodsmentioning

confidence: 99%

Fast-track concepts in routine pediatric surgery: a prospective study in 436 infants and children

Reismann

Dingemann

Wolters

et al. 2008

Langenbecks Arch Surg

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“…A greater initial dose followed by maintenance doses not exceeding recommended maximum daily doses is generally recommended. Peak plasma levels are rapidly achieved after oral ingestion, but there is a 1-2 h lag before the maximum therapeutic effect; the onset of analgesia after IV administration may be much faster [ 62 ]. As rectal bioavailability is much reduced and more variable than oral bioavailability, greater initial doses are recommended when this route is used except in the premature infant.…”

Section: Acetaminophen (Paracetamol)mentioning

confidence: 99%

Pain Assessment and Management

Howard

2014

Neonatal Anesthesia

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Tolerance and analgesic efficacy of a new i.v. paracetamol solution in children after inguinal hernia repair

Abstract: A single infusion of i.v. paracetamol 15 mg.kg(-1) produced analgesia similar to a single infusion of propacetamol 30 mg.kg(-1) following inguinal hernia repair in children. Paracetamol i.v. 15 mg.kg(-1) was better tolerated at the injection site than propacetamol.

Cited by 99 publications

References 18 publications

Analgesic Efficacy of Intravenous Versus Rectal Acetaminophen After Adeno Tonsillectomy in Children

Analgesic Efficacy of Intravenous Versus Rectal Acetaminophen After Adeno Tonsillectomy in Children

Fast-track concepts in routine pediatric surgery: a prospective study in 436 infants and children

Pain Assessment and Management

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