Tolerance and efficacy of platelet-rich plasma injections in Peyronie's disease: Pilot study

Schirmann, A.; Boutin, Emmanuelle; Faix, A.; Yiou, R.

doi:10.1016/j.purol.2022.05.004

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…67 This treatment has been gaining interest in PD management in recent years. 68 The efficacy and safety of PRP injections were recently investigated in a pilot study on 17 patients, resulting in a significant improvement over all three PDQ domains, a reduction of mean penile curvature by 11.8 • , and an improvement in EF. 68 PRP presents an interesting direction in conservative treatment of PD, however, further research is necessary to assess its clinical value in RCTs.…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

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Current trends in non‐surgical management of Peyronie's disease—A narrative review

Kozub,

Suleja,

Chłosta

et al. 2023

Andrology

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Peyronie's disease (PD) is a connective tissue disorder affecting the tunica albuginea. It can cause pain and penile deformation, and its prevalence increases with age. Although surgery is the gold standard for the chronic phase of the disease, there are several conservative treatment methods available, and the optimal management of the acute phase of the disease remains a matter of debate. In this article, we aim to summarize the recent trends in research on the subject of non‐surgical treatment of PD. The search was performed in PubMed, Scopus, and Web of Science databases and included studies in English published between 2012 and 2022 investigating the clinical outcomes of non‐surgical PD management in humans. We have identified 20 distinct conservative treatment strategies. Among the oral therapeutics, only the use of phosphodiesterase type 5 inhibitors is currently recommended for clinical use in patients with concomitant erectile dysfunction. The use of collagenase from Clostridium histolyticum is supported by the best quality evidence in terms of intralesional injections for patients suffering from significant penile curvature; however, interferon alpha‐2b can also be an option in such patients. Among other non‐invasive methods, extracorporeal shockwaves can be useful for pain reduction, and penile traction therapy can lead to a reduction in penile curvature and plaque size. Despite a wide range of non‐surgical methods available for PD treatment, the majority are not supported by sufficient scientific evidence, and the treatment efficacy is underwhelming. Further research on the subject of non‐surgical management of PD is highly warranted.

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Section: Platelet-rich Plasmamentioning

confidence: 99%

“…The drug contains the patient's plasma with an increased concentration of thrombocytes 67 . This treatment has been gaining interest in PD management in recent years 68 …”

Section: Intralesional Injectionsmentioning

confidence: 99%

Current trends in non‐surgical management of Peyronie's disease—A narrative review

Kozub,

Suleja,

Chłosta

et al. 2023

Andrology

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“…Peyronie’s disease (PD) is a disease caused by fibrotic plaque developed in the penis tissue, which often leads to curved and painful erections that affect 0.4%–9% of men ( Cui et al, 2022 ). The pathophysiology of PD is commonly considered to be the development of fibrotic plaque in the tunica albuginea (TA) following penis trauma ( Schirmann et al, 2022 ). Profibrotic factors, including excessive reactive oxygen species (ROS), transforming growth factor (TGF) β1 and plasminogen activator inhibitor-1, activate and upregulate the production of collagen ( Chung and Yafi, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Identifying hub genes, key pathways and key immune-related genes in Peyronie’s disease by integrated bioinformatic analysis

Cui

Chen

et al. 2022

Front. Pharmacol.

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Scarring diseases, such as Peyronie’s disease (PD), usually lead to disorders in the immune system. Previous studies suggested that the PD process was regulated by immune signaling. However, the pathogenetic mechanism remains incompletely characterized. This article used bioinformatic approaches to identify hub genes, key pathways and key immune-related genes that play essential roles in PD pathogenesis. Two Gene Expression Omnibus (GEO) datasets, GSE126005 and GSE146500, were used to analyse the transcriptional profiling in both PD and normal samples. R software was applied to examine the difference in the expression of hub genes and key immune-related genes. The candidates for hub genes were further validated through protein–protein interactions (PPIs), gene correlation, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. In addition, candidate miRNA‒mRNA pairs were functionally assessed. A total of 39 candidate genes were identified, the expression levels of which in PD fibroblast cells were different from those in normal cells (16 showed reduced expression in PD and 21 candidates overexpressed in PD). We found that these genes could interact with each other through PPI analysis. According to the functional enrichment analysis, the candidates may regulate some major biological processes, including cytokine‒cytokine receptor interactions and the JAK-STAT signaling pathway. IL6, IL21R, IFNE, CXCL2, EGF, and ANGPTL5 were identified as key immune-related genes. The findings may help understand the role of immunologic contributors in PD, thus shedding light on the development of more effective strategies to prevent and treat this kind of disease.

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French translation of the Peyronie's disease questionnaire: A pilot study

Dang,

Ferretti,

Ducrot

et al. 2024

The French Journal of Urology

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Tolerance and efficacy of platelet-rich plasma injections in Peyronie's disease: Pilot study

Cited by 9 publications

References 16 publications

Current trends in non‐surgical management of Peyronie's disease—A narrative review

Current trends in non‐surgical management of Peyronie's disease—A narrative review

Identifying hub genes, key pathways and key immune-related genes in Peyronie’s disease by integrated bioinformatic analysis

French translation of the Peyronie's disease questionnaire: A pilot study

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