Tolerance Induction by Upregulation of Regulatory T-Cells (Expressing Foxp3 and Ctla-4) by Coculture With in Vitro Modified Human Monocytes Bearing Regulatory Function

Ruhnke, Maren; Ungefroren, Hendrik; Richter, Audrey; Zehle, G.; Burdelski, M.; Kremer, Bernd; Fändrich, F.

doi:10.1097/00007890-200407271-01411

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2010

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“…Matrigel is isolated from the natural basement membrane of mouse sarcoma cells and therefore contains a myriad of ECM components and growth factors35, 36 conducive to cell attachment, proliferation, and/or differentiation to all three lineages;37–43 its efficacy is most likely due to it having many factors in optimal native concentrations. Though collagen IV and heparan sulfate proteoglycans are also present, laminin is its primary component 36.…”

Section: Matrigelmentioning

confidence: 99%

Reconstructing the Differentiation Niche of Embryonic Stem Cells Using Biomaterials

Dickinson

Kusuma

Gerecht

2010

Macromolecular Bioscience

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The biochemical cues and topographical architecture of the extracellular environment extensively influence ES cell fate. The microenvironment surrounding the developing embryo presents these instructive cues in a complex and interactive manner in order to guide cell fate decisions. Current stem cell research aims to reconstruct this multifaceted embryonic niche to recapitulate development in vitro. This review focuses on 2D and 3D differentiation niches created from natural and synthetic biomaterials to guide the differentiation of ES cells toward specific lineages. Biomaterials engineered to present specific physical constraints are also reviewed for their role in differentiation.

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