Tolerance of canine anastomoses to intraoperative radiation therapy

Tepper, Joel E.; Sindelar, William F.; Travis, Elizabeth L.; Terrill, Richard; Padikal, Thomas N.

doi:10.1016/0360-3016(83)90385-1

Cited by 50 publications

(9 citation statements)

References 10 publications

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“…Experimental studies of IORT in canine models were undertaken in to late 1960s by Abe and Arakawa 8 and in the early 1980s at the National Institutes of Health, and at Colorado State University to assess changes resulting from large single doses of radiation therapy in a variety of tissues. [9][10][11][12][13][14][15][16][17][18][19] These studies enabled dose guidelines to be established, which appeared to be safe for the clinical application of IORT. Table 1 shows an overall summary of the recommended doses of IORT for abdominal and retroperitoneal organs in humans.…”

Section: Experimental Trialsmentioning

confidence: 99%

“…1 It involved 108 patients treated at 14 institutions in Japan, and IORT doses were as high as 40 Gy. Peripheral nerves Յ15 [14][15][16] IORT, Intraoperative radiotherapy Bile duct No safe limit 10,19 Although the median patient survival was 5.5 months, many patients experienced pain relief, suggesting effective palliation. From this study it was recommended that if a significant part of duodenum is to be included in the IORT field then the IORT dose should be limited to less than 30 Gy.…”

Section: Clinical Experiencementioning

confidence: 99%

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Intraoperative radiotherapy for pancreatic adenocarcinoma

Sunamura

Kobari

Lozonschi

et al. 1998

Journal of Hepato-Biliary-Pancreatic Surgery

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Intraoperative radiotherapy (IORT) is an innovative treatment approach for cancer of the pancreas. The common causes of treatment failure in pancreatic cancer are regional recurrence and distant metastasis. While at present the benefit of IORT in unresectable pancreatic cancer is still controversial and awaits further prospective trials for its clarification, the experience gathered over a period of 30 years with IORT for pancreatic cancer does suggest that IORT should be part of the adjuvant therapy of surgical resection. A combination with pre- or postoperative external beam radiotherapy and chemotherapy may be beneficial for both resectable and unresectable patients. IORT was shown to be a relatively safe intervention and it notably improved the quality of life of patients with locally advanced pancreatic carcinomas by alleviating their pain. Here, we summarize and discuss the experience reported to date and present our historical analysis of IORT for pancreatic cancer.

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Section: Experimental Trialsmentioning

confidence: 99%

Section: Clinical Experiencementioning

confidence: 99%

Intraoperative radiotherapy for pancreatic adenocarcinoma

Sunamura

Kobari

Lozonschi

et al. 1998

Journal of Hepato-Biliary-Pancreatic Surgery

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“…Experimental data concerning normal tissue tolerance to IORT has been generated in dogs [6,[14][15][16][17][18][19]. Sindelar and coworkers carried out a series of investigations using dogs in an attempt to characterize normal tissue tolerance of intraoperative radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

Biliodigestive Anastomosis After Intraoperative Irradiation in Swine

Kaiser

Mueller

Sauerwein

et al. 2005

Journal of Investigative Surgery

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A large animal model was established to investigate the feasibility and suitable dosage of intraoperative radiation therapy (IORT) to the hepatic hilum before biliary-enteric anastomosis is performed. Twenty-two Pietrain Hampshire pigs underwent gallbladder and proximal bile duct resection followed by IORT using 20-40 Gy and performing biliary-enteric anastomosis. In the follow-up period of 56 days, pigs developed dose-dependent complications like stenosis of the biliary-enteric anastomosis. Results demonstrate that IORT of the liver hilum up to 20 Gy is safe with acceptable early complications in the presented animal model. The porcine biliary-enteric anastomosis can tolerate intraoperative irradiation up to a dosage of 40 Gy without disruption.

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“…At surgery, a dose of [15][16][17][18][19][20] Gy IORT (most patients received 20 Gy) was delivered for gross disease and a bypass of the bile duct andlor duodenum was performed as indicated. Between 1978 and 1985, investigators at the Massachusetts General Hospital entered 63 patients on a single-arm pilot s t~d y .~,~~ Patients received 10 Gy of fractionated EBRT over l week prior to exploration.…”

Section: Unresectable (But Localized) Pancreatic Cancermentioning

confidence: 99%

Intraoperative radiotherapy for pancreatic carcinoma: Experimental and clinical studies

Kinsella¹,

Sindelar²

1996

Cancer

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Intraoperative radiotherapy (IORT) is an innovative treatment approach that has been tested in several Phase 1-11 studies and small Phase 111 trials in patients with resectable and unresectable pancreatic cancer. The technical approach and dose guidelines for adjacent normal tissues have been established in a series of experiments using a large animal (canine) model. This article reviews the experimental and clinical studies of IORT in cancer of the pancreas.

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Tolerance of canine anastomoses to intraoperative radiation therapy

Cited by 50 publications

References 10 publications

Intraoperative radiotherapy for pancreatic adenocarcinoma

Intraoperative radiotherapy for pancreatic adenocarcinoma

Biliodigestive Anastomosis After Intraoperative Irradiation in Swine

Intraoperative radiotherapy for pancreatic carcinoma: Experimental and clinical studies

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