Tolerance of interferon‐alpha therapy in children with chronic hepatitis B

Liberek, Anna; Łuczak, G; Korzon, Maria; Szlagatys-Sidorkiewicz, Agnieszka; Bako, Wanda; Góra-Gębka, Magdalena; Rytlewska, M; Sikorska-Wiśniewska, Grazyna

doi:10.1111/j.1440-1754.2004.00361.x

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…A full thyroid profile should be obtained whenever central hypothyroidism is a consideration. While thyroid and autoimmune diseases are known side effects of interferon therapy in adults, this has not been reported in the pediatric population (14–16).…”

Section: Discussionmentioning

confidence: 99%

Hypopituitarism in PHACES Association

Goddard

Liang

Chamlin

et al. 2006

Pediatric Dermatology

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The association consisting of posterior fossal malformations, cervicofacial, hemangiomas, arterial anomalies, cardiac defects, eye anomalies, and sternal clefting, or supraumbilical raphe, refers to the occurrence of congenital structural and vascular anomalies in the presence of a facial hemangioma. We report a patient with this association, growth retardation, and developmental delay who was found to have a partially empty sella turcica, central hypothyroidism, and growth hormone deficiency. Endocrinologic evaluation should be considered in any infant with this association.

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Section: Discussionmentioning

confidence: 99%

Hypopituitarism in PHACES Association

Goddard

Liang

Chamlin

et al. 2006

Pediatric Dermatology

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“…No significant alteration in thyroid function was observed 10 . In one study, 31 children who were treated with IFN were evaluated.…”

Section: Patients Without Thyroid Dysfunction (N = 45)mentioning

confidence: 88%

The Incidence and Evolution of Thyroid Dysfunction During Interferon-α Therapy in Children with Chronic Hepatitis Β Infection

Kuloğlu¹,

Kansu²,

Berberoğlu³

et al. 2007

Journal of Pediatric Endocrinology and Metabolism

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“…Side effects of INF in children are flu-like symptoms, headache, depression, loss of appetite, anaemia, leukopenia, and thrombocytopenia. The appearance of side effects does not usually require cessation of therapy and has no prognostic value for its outcome [34]. Pegylated interferon (PEG-IFN) is interferon with a polyethylene glycol moiety attached.…”

Section: Hepatitis B Virusmentioning

confidence: 99%

Hepatitis B virus and hepatitis C virus infections in children

Tovo¹,

Lazier²,

Versace³

2005

Current Opinion in Infectious Diseases

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There are doubts as to the long-term persistence of anti-hepatitis B immunization in low-endemicity areas. Routine hepatitis C virus testing in pregnancy is not recommended as there are no available prophylactic measures. Although hepatitis B and C virus infections are usually asymptomatic or with mild manifestations in childhood, concerns around their long-term clinical impact suggest the need for early treatment. Children should preferably be treated in the context of targeted trials for a better understanding of the efficacy and tolerance of drugs currently used in adults.

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Tolerance of interferon‐alpha therapy in children with chronic hepatitis B

Abstract: The side-effects of the IFN-alpha therapy in children such as fever, flu-like symptoms and bone marrow suppression are common, but transient and mild.

Cited by 10 publications

References 30 publications

Hypopituitarism in PHACES Association

Hypopituitarism in PHACES Association

The Incidence and Evolution of Thyroid Dysfunction During Interferon-α Therapy in Children with Chronic Hepatitis Β Infection

Hepatitis B virus and hepatitis C virus infections in children

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