Tolerance of Pseudomonas aeruginosa to Melaleuca alternifolia (tea tree) oil is associated with the outer membrane and energy-dependent cellular processes

Longbottom, Chelsea J; Carson, Christine; Hammer, Katherine A.; Mee, Brian; Riley, Thomas V.

doi:10.1093/jac/dkh359

Cited by 101 publications

(64 citation statements)

References 26 publications

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“…According to Longbottom et al, its resistance appears to be due to its external membrane structure, particularly impermeable to essential oil molecules and the action of efflux mechanisms, which enhance the protection of the bacteria against the essential oil action [30].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activity of Mentha Pulegium Essential Oil Against Avian Isolated Esbl Producing Bacteria and Its Synergistic Potential With Antibiotics

Yahiaoui

Benameur

Ben-Mahdi

2017

Int J Pharm Pharm Sci

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Objective: The aim of this study was to evaluate the antibacterial effect of Algerian Mentha pulegium essential oil against extended-spectrum β-lactamases (ESBL) producing bacteria isolated from avian livestock. The synergistic interactions between conventional antibiotics and Mentha pulegium essential oil were assessed. Methods:Essential oil composition was determined by gas chromatograph-flame ionization detector (GC/FID), gas chromatograph-mass spectrometer (GC/MS) analysis.Antibacterial activity of Mentha pulegium essential oil against ESBL producing bacteria was investigated by disc diffusion assay. Minimum inhibitory concentration (MIC) of essential oil and it synergistic interaction with conventional antibiotics were determined by micro-broth dilution method and checkerboard test, respectively. Results:The results indicate that Mentha pulegium essential oil with a high amount of pulegone (88.78%) had high inhibitory activity against the tested strains and particularly displays a satisfactory action against the studied ESBL producing bacteria from animal origin, with a diameter ranging from 13 to 26 mm. Out of 51 combinations tested between essential oil and antibiotics 60.78 % showed total synergy, 13.72 % had presented a partial synergy. The best antibacterial activities were obtained with the combination of Mentha pulegium essential oil and cefazolin, cefotaxime and gentamycin. Conclusion:This study allowed concluding that Mentha pulegium essential oil showed not only satisfactory antibacterial properties, but also acts synergistically combined with conventional antibiotics, which make it a promising alternative to antimicrobial drugs; beside that, it might reduce the minimum effective dose of the drugs which minimizes their possible side effects.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Activity of Mentha Pulegium Essential Oil Against Avian Isolated Esbl Producing Bacteria and Its Synergistic Potential With Antibiotics

Yahiaoui

Benameur

Ben-Mahdi

2017

Int J Pharm Pharm Sci

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“…Instead, research has concentrated on how this organism is able to tolerate higher concentrations of TTO and/or components. These studies have indicated that tolerance is associated with the outer membrane by showing that when P. aeruginosa cells are pretreated with the outer membrane permeabilizer polymyxin B nonapeptide or EDTA, cells become more susceptible to the bactericidal effects of TTO, terpinen-4-ol, or ␥-terpinene (99,103).…”

Section: Antibacterial Activitymentioning

confidence: 99%

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

2006

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SUMMARY Complementary and alternative medicines such as tea tree (melaleuca) oil have become increasingly popular in recent decades. This essential oil has been used for almost 100 years in Australia but is now available worldwide both as neat oil and as an active component in an array of products. The primary uses of tea tree oil have historically capitalized on the antiseptic and anti-inflammatory actions of the oil. This review summarizes recent developments in our understanding of the antimicrobial and anti-inflammatory activities of the oil and its components, as well as clinical efficacy. Specific mechanisms of antimicrobial and anti-inflammatory action are reviewed, and the toxicity of the oil is briefly discussed.

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“…Differences among the volatiles in the essential oils, which may be responsible for the differences in their antimicrobial performances against an array of Gram-positive and Gram-negative bacteria, were found. The lower susceptibility of Gram-negative bacteria may be due to the distinctive properties of its outer membrane (Longbottom et al, 2004). Gram-negative strains are generally more resistant than Gram-positive strains, and this trait has been attributed to the external lipopolysaccharide wall that surrounds the peptidoglycan cell wall of Gram-negative bacteria.…”

Section: Essential Oilsmentioning

confidence: 99%

Potential Roles of Essential Oils on Controlling Plant Pathogenic Bacteria Xanthomonas Species: A Review

Bajpai¹,

Kang²,

Xu³

et al. 2011

The Plant Pathology Journal

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Tolerance of Pseudomonas aeruginosa to Melaleuca alternifolia (tea tree) oil is associated with the outer membrane and energy-dependent cellular processes

Abstract: Increased tolerance to tea tree oil in P. aeruginosa is directly related to the barrier and energy functions of the outer membrane, and may involve efflux systems.

Cited by 101 publications

References 26 publications

Antibacterial Activity of Mentha Pulegium Essential Oil Against Avian Isolated Esbl Producing Bacteria and Its Synergistic Potential With Antibiotics

Antibacterial Activity of Mentha Pulegium Essential Oil Against Avian Isolated Esbl Producing Bacteria and Its Synergistic Potential With Antibiotics

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

Potential Roles of Essential Oils on Controlling Plant Pathogenic Bacteria Xanthomonas Species: A Review

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