Tolerance of rofecoxib in patients with adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs)

Fernández-Meléndez, Salvador; Miranda, A. L.P.; Carmona, Martinez J.F.; Diaz, Juan Ignacio; Barceló, Jose M; Vega, José M.; Garcı́a, Juan José

doi:10.1016/s0091-6749(02)81546-9

Cited by 5 publications

(3 citation statements)

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“…Despite these warnings, several studies and case reports have reported tolerance to COX-2 inhibitors upon OPT in the majority of patients with confirmed intolerance to aspirin or other NSAIDs. 11–22 These reports described patients with histories of one or more forms of the following reactions to aspirin and other nonselective NSAIDs: urticaria, angioedema, urticaria with angioedema, asthma exacerbations, rhinitis, and anaphylaxis. Some authors have concluded that inhibition of COX-1 may be the initiator of the aspirin- and NSAID -induced intolerance in some susceptible individuals, but most authors of these studies and reviews of aspirin and NSAID intolerance have advised caution with OPT with COX-2 inhibitors, as patient reactions vary.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have concluded that inhibition of COX-1 may be the initiator of the aspirin- and NSAID -induced intolerance in some susceptible individuals, but most authors of these studies and reviews of aspirin and NSAID intolerance have advised caution with OPT with COX-2 inhibitors, as patient reactions vary. 6,11–23 The exact mechanisms for intolerance to multiple NSAIDs or COX-2 inhibitors are not clear. 4–6,23…”

Section: Discussionmentioning

confidence: 99%

“…Of the studies cited previously, 6,11–23 2 were controlled trials describing positive cross-reactivity between aspirin (or other NSAIDs) and the COX-2 inhibitors in patients with cutaneous reactions to aspirin or other NSAIDs. 6,23 In one trial that investigated tolerance to selective and preferential COX-2 inhibitors, 110 participants (32 men) with a history of angioedema, with or without urticaria related to NSAIDs, were first challenged with their individual offending agent and then were given ibuprofen to confirm the allergic reaction.…”

Section: Discussionmentioning

confidence: 99%

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Angioedema Associated with Aspirin and Rofecoxib

Marshall

2005

Ann Pharmacother

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Angioedema Associated with Aspirin and Rofecoxib

Marshall

2005

Ann Pharmacother

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Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs): a systematic structured review of the literature

et al. 2007

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Adverse events triggered by non-steroidal antiinXammatory drugs (NSAIDs) are among the most common drug-related intolerance reactions in medicine; they are possibly related to inhibition of cyclooxygenase-1. Coxibs, preferentially inhibiting cyclooxygenase-2, may therefore represent safe alternatives in patients with NSAID intolerance. We reviewed the literature in a systematic and structured manner to identify and evaluate studies on the tolerance of coxibs in patients with NSAID intolerance. We searched MEDLINE (1966MEDLINE ( -2006, the COCHRANE LIBRARY (4th Issue 2006) and EMBASE (1966EMBASE ( -2006 up to December 9, 2006, and analysed all publications included using a predeWned evaluation sheet. Symptoms and severity of adverse events to coxibs were analysed based on all articles comprising such information. Subsequently, the probability for adverse events triggered by coxibs was determined on analyses of double-blind prospective trials only. Among 3,304 patients with NSAID intolerance, 119 adverse events occurred under coxib medication. All adverse events, except two, have been allergic/urticarial in nature; none was lethal, but two were graded as life-threatening (grade 4). The two non-allergic adverse events were described as a grade 1 upper respiratory tract haemorrhage, and a grade 1 gastrointestinal symptom, respectively. In 13 double-blind prospective studies comprising a total of 591 patients with NSAID intolerance, only 13 adverse reactions to coxib provocations were observed. The triggering coxibs were rofecoxib (2/286), celecoxib (6/208), etoricoxib (4/ 56), and valdecoxib (1/41). This review documents the good tolerability of coxibs in patients with NSAID intolerance, for whom access to this class of drugs for short-term treatment of pain and inXammation is advantageous.

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