Tolerance of skin care regimen in healthy, full-term neonates

Abstract

PurposeTo assess the tolerance of a baby cleanser and lotion (both lightly fragranced) on healthy, full-term neonates.Materials and methodsTwenty-six infant–mother pairs were enrolled in a 6-week, nonrandomized, controlled-use study that took place in the routine setting of a pediatric clinic and mothers’ homes. During study weeks 1 to 6, neonates were bathed by their mother with water and a test cleanser (JOHNSON’S® HEAD-TO-TOE® Baby Wash). During study weeks 1 to 3, mothers also applied test lotion (JOHNSON’S® Baby Lotion) to the babies’ skin immediately after bathing and one to three times/day on bathing and non-bathing days. During study weeks 4 to 6, no lotion was applied. At baseline and weeks 3 and 6, the infants’ pediatrician or mother or both performed visual skin assessments.ResultsTwenty-three infant–mother pairs completed the study. The mean age of neonates at enrolment was 17.4 days (range, 13–28 days). Pediatrician observations found no clinical signs of irritation, erythema, or dryness with any significant difference in scores of these parameters compared with baseline throughout the study. Assessment of skin softness, smoothness, dryness, and overall skin condition was very good at baseline and remained so with minimal changes throughout the study. Mothers reported improvements versus baseline (P ≤ 0.05) in overall skin appearance, moisturization, softness, and smoothness on the arms and legs at weeks 3 and 6. A total of four (15.4%) subjects experienced adverse events. For three of the subjects, the investigator suspected that the adverse events were unrelated to either of the test products. In one participant, the cause of the adverse event could not be determined.ConclusionThe use of a lightly fragranced nonstinging baby cleanser, with or without a lightly fragranced baby lotion, was well tolerated by newborns and resulted in observable skin benefits per the pediatricians’ and mothers’ assessment.

Skin Care in Neonates and Infants: A Scoping Review

“…Plain water [36] Rinse-off product "soap" [36] Head Plain water [36] Rinse-off product "soap" [36] Topical application of leave-on products Body skin Emulsions "Moisturizer" [36] [40] "Lotion" [56,47,31,49,28,37] [ 62,27] "Cream" [7,37] […”

“…The mapping of skin care interventions against care goals is shown in Table 2. The interventions in the category "bathing," having a bath or wash, were most often associated with "cleansing" (e.g., [27,31]), and using "cleanser/soap" was most often associated with "maintaining healthy skin" (e.g., [37,47]) or "improving skin barrier function" (e.g., [40,48]). The category "wiping" refers either to the whole body or to the diaper area.…”

“…Diaper area "Cream" [49] [34] [65,66] "Powder" [65] "Lotion" [55] Total (n) ter-soaked cotton wipes" in the diaper area were associated with maintaining healthy skin as well as "wet wipes with emulsion" [7,28]. In the category "topical application of leave-on products," "lotion" was mostly associated with "maintaining healthy skin" (e.g., [37,47,49]). "Cream" was mostly associated with "prevention of atopic dermatitis" (e.g., [39,50,51]).…”

Newborn Skin Care is the Basis for Prevention of Atopic Dermatitis Development

“…Данные контролируемых исследований здоровых младенцев и пациентов с АтД подтверждают целесообразность использования увлажняющих средств с целью восстановления барьерных свойств кожи [29][30][31]. С профилактической целью можно применять увлажняющие средства и при этом учитывать необходимость их исполь-зования не реже двух раз в неделю [32,33].…”