Tolerance to morphine in the rat: Associative and nonassociative effects.

Tiffany, Stephen T.; Maude-Griffin, Peg M.

doi:10.1037/0735-7044.102.4.534

Cited by 53 publications

(51 citation statements)

References 49 publications

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“…From fifth day, the TFLs began to show a progressive decline until they were indistinguishable from the response of sham animals. This may be due to opioid tolerance, which is a characteristic effect of repeated administrations of opiates [Tiffany and Maude-Griffin, 1988].…”

Section: Discussionmentioning

confidence: 99%

A possible involvement of β-endorphin, substance P, and serotonin in rat analgesia induced by extremely low frequency magnetic field

Bao

Shi

Huo

et al. 2006

Bioelectromagnetics

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Most of the research concerning magnetic antinociception was focused on brief exposure less than 1 h. The main purpose of the present study was to determine the effect of extremely low frequency (ELF) magnetic field (MF) repeated exposures on rats in inducing antinociception and to find the effective analgesic "time window." Meanwhile this investigation was to examine the role of central beta-endorphin, substance P, and 5-HT in magnetic analgesia. We found tail flick latencies (TFLs) increased significantly after the rats were exposed to 55.6 Hz, 8.1 mT magnetic field for 4 days, 6 h each day. The analgesic effects seemed to decrease gradually when the rats were exposed daily for another 10 days. Their levels of TFLs decreased within 1 day when the rats were removed after a 4-day exposure. The concentrations of hypothalamus beta-endorphin, substance P, and brainstem serotonin (5-HT) were increased significantly on Day 4. However, no differences were found when rats were exposed for another 10 days, and there were no significant increases when rats were removed after the fourth day of exposure and tested for nociception on Days 5 and 7 with no changes in the biochemical markers at 7 days. These results suggest that the ELF magnetic field has analgesic effect, but only on Days 3 and 4. The effect may be associated with increases in endogenous beta-endorphin, substance P, and 5-HT stimulated by the 55.6 Hz, 8.1 mT magnetic field.

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Section: Discussionmentioning

confidence: 99%

A possible involvement of β-endorphin, substance P, and serotonin in rat analgesia induced by extremely low frequency magnetic field

Bao

Shi

Huo

et al. 2006

Bioelectromagnetics

View full text Add to dashboard Cite

show abstract

“…There is growing evidence that a purely pharmacological explanation of drug tolerance is inadequate (Siegel, 1975(Siegel, ,1976(Siegel, ,1977(Siegel, ,1988(Siegel, ,1989Tiffany & Maude-Griffin, 1988). Drug adaptation systems are modulated by a number of nonpharmacological events, including conditioning manipulations.…”

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confidence: 99%

Stimulus conditions influencing the development of tolerance to repeated cold exposure in rats

Kissinger

Riccio

1995

Animal Learning & Behavior

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Tolerance to an environmental cold challenge in rats is eliminated when cold exposure occurs in a context different from the adaptation context, indicating that learning mechanisms playa role in thermoregulation (Riccio, MacArdy, & Kissinger, 1991). This finding, analogous to outcomes obtained with drug tolerance, was investigated in the present study. Experiment 1 demonstrated that a change in both proximal and distal contextual cues disrupts an established cold adaptation, an outcome consistent with the view that associative processes contribute to the tolerance. In Experiment 2, although cold tolerance persisted over a 7-day retention interval, the disruption of tolerance by a shift in context was attenuated with the delay of testing. This finding suggests that the precise stimulus attributes of the context were forgotten over the interval. Experiment 3 demonstrated that cold-tolerance disruption is due to the actual change in context and not to novelty of the test context. Experiment 4 showed that changing the context associated with each cold exposure impaired the development oftolerance. The results of these experiments provide additional evidence that cold tolerance is regulated at least partially by associative learning processes.

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“…Studies that have used a wide variety of response measures and drugs have found that the degree of tolerance observed following repeated drug administration is inversely related to IDI. For example, this relationship has been reported for the hypothermic response to ethanol (Stewart et al 1992), the anticonvulsant effect of clobazam (Wildin and Pleuvry 1992), the reduction of motor activity induced by haloperidol (Carey and De Veaugh-Geiss 1984), analgesia produced by morphine (Tiffany and Maude-Griffin 1988;Dafters and Odber 1989;Tiffany et al 1992), and some measures of subjective responses to nicotine (Perkins et al 1995).…”

Section: Introductionmentioning

confidence: 85%

Amphetamine-induced withdrawal responding: effects of repeated drug administration

1997

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The first purpose of this research was to assess withdrawal haloperidol-appropriate lever responding 24 h after a single administration of 0.35, 0.75, and 1.00 mg/kg amphetamine. Rats were trained to discriminate among 0.35 mg/kg amphetamine (AM), distilled water (DW), and 0.033 mg/kg haloperidol (HA) in a three-lever drug discrimination task. An increase in HA-appropriate lever responding occurred following the 1.00 mg/kg dose of AM but not after either of the lower doses. The second purpose was to determine the effect of repeated administration of 0.75 mg/kg AM. Two groups of animals were given five administrations of drug, one at an interdose interval (IDI) of 24 h and the other at an IDI of 48 h. Control animals were given injections of DW. Increased HA-appropriate lever responding occurred in both of the AM-treated groups. The magnitude of this effect tended to be less in the 48-h IDI group. Thus, even though HA-lever responding was not evident 24 h after a single administration of 0.75 mg/kg AM, it was produced by repeated administration of this dose, even at 48-h intervals.

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Tolerance to morphine in the rat: Associative and nonassociative effects.

Cited by 53 publications

References 49 publications

A possible involvement of β-endorphin, substance P, and serotonin in rat analgesia induced by extremely low frequency magnetic field

A possible involvement of β-endorphin, substance P, and serotonin in rat analgesia induced by extremely low frequency magnetic field

Stimulus conditions influencing the development of tolerance to repeated cold exposure in rats

Amphetamine-induced withdrawal responding: effects of repeated drug administration

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