2018
DOI: 10.3389/fimmu.2018.00274
|View full text |Cite
|
Sign up to set email alerts
|

Tolerogenic Dendritic Cells in Solid Organ Transplantation: Where Do We Stand?

Abstract: Over the past century, solid organ transplantation has been improved both at a surgical and postoperative level. However, despite the improvement in efficiency, safety, and survival, we are still far from obtaining full acceptance of all kinds of allograft in the absence of concomitant treatments. Today, transplanted patients are treated with immunosuppressive drugs (IS) to minimize immunological response in order to prevent graft rejection. Nevertheless, the lack of specificity of IS leads to an increase in t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
78
0
5

Year Published

2019
2019
2023
2023

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 88 publications
(83 citation statements)
references
References 130 publications
(158 reference statements)
0
78
0
5
Order By: Relevance
“…Maternal‐fetal immune interactions primarily involve inhibiting rejection immunity and inducing immune tolerance. Our understanding of immunology has advanced rapidly in the fields oforgan transplantation and cancer, which share many common immune mechanisms with pregnancy (Figure A). Natural immunity, aimed at the rapid removal of foreign substances invading the body, and acquired immunity, which attacks or induces immune tolerance to foreign antigens based on information recognized by dendritic cells, are both fundamental immunological mechanisms but display different characteristics.…”
Section: Immunological Problems In Infertilitymentioning
confidence: 99%
“…Maternal‐fetal immune interactions primarily involve inhibiting rejection immunity and inducing immune tolerance. Our understanding of immunology has advanced rapidly in the fields oforgan transplantation and cancer, which share many common immune mechanisms with pregnancy (Figure A). Natural immunity, aimed at the rapid removal of foreign substances invading the body, and acquired immunity, which attacks or induces immune tolerance to foreign antigens based on information recognized by dendritic cells, are both fundamental immunological mechanisms but display different characteristics.…”
Section: Immunological Problems In Infertilitymentioning
confidence: 99%
“…In other models, adaptive Tregs kill and prevent the maturation of immature DCs in a non-MHC dependent manner, using perforin combined with a different set of granzymes to prevent the initiation of responses (25). The contrasts between adaptive and natural Tregs in how they use MHC-antigens illustrate the diversity of click assemblies controlling T-cell dependent outcomes (26). In yet another click interaction, NK cells prune DCs with low levels of MHC to enhance T-cell responses (27).…”
Section: Evidence Of Clicks In Actionmentioning
confidence: 99%
“…In contrast, there are DCs that show immunoregulatory function and improve allograft survival. 18 The tolerogenic DCs have low expression of a costimulatory molecule, show resistance to maturation and secrete anti-inflammatory molecules such as IL-10 and TGF-α. and control the T cell proliferation, and promote the differentiation of regulatory CD4 + T cells.…”
Section: Dendritic Cells (Dcs)mentioning
confidence: 99%
“…and control the T cell proliferation, and promote the differentiation of regulatory CD4 + T cells. 18 The concept of donor-specific transfusion (DST) is well established to induce transplantation tolerance. Pretransplant infusion of immature donor-derived DCs in combination with short-term immunosuppression has shown reproducible results in laboratory animal models, suggesting the importance of DCs in the transplantation.…”
Section: Dendritic Cells (Dcs)mentioning
confidence: 99%