Toll-like receptor 3 gene polymorphisms are not associated with the risk of hepatitis B and hepatitis C virus infection

Sá, Keyla Santos Guedes de; Pires-Neto, Orlando de Souza; Gomes, Samara Tatielle Monteiro; Amoras, Ednelza da Silva Graça; Conde, Simone Regina da Silva; Demachki, Sâmia; Azevedo, Vânia Nakauth; Machado, Luiz Fernando Almeida; Martins-Feitosa, Rosimar Neris; Ishak, Marluísa de Oliveira Guimarães; Ishak, Ricardo; Vallinoto, Antônio Carlos Rosário

doi:10.1590/0037-8682-0008-2015

Cited by 12 publications

(12 citation statements)

References 20 publications

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“…They found significant difference between patient and control groups for only one polymorphism (rs1879026 (G/T)) (Al-Qahtani et al 2012). In another study, Sá et al (2015) investigated TLR 3 gene polymorphism among 35 HBV patients, 74 HCV patients and 299 healthy volunteers. They did not found statistically significant difference in distribution of allele, genotype and haplotype frequencies between the two groups (Sa et al 2015).…”

Section: Discussionmentioning

confidence: 98%

Investigation of 1377C/T polymorphism of the Toll-like receptor 3 among patients with chronic hepatitis B

et al. 2016

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The immunopathogenesis of chronic hepatitis B (CHB) has not been clarified yet. Toll-like receptors (TLR) are a receptor family that initiates immunity with exogenous-endogenous ligands and plays a role in the pathogenesis of infections. In this study, we aimed to investigate the frequency of TLR 3 1377C/T (rs3775290) polymorphism and its role in patients with CHB. We included 50 healthy individuals as control group and 73 active and 43 inactive hepatitis B patients. All DNA samples were isolated from blood samples. For the detection of TLR 3 1377C/T single-nucleotide polymorphism, restriction fragment length polymorphism was used. A statistically significant difference was determined in Hepatitis B virus (HBV) DNA levels of CHB patients with the CC, CT, and TT genotypes (p = 0.013). The highest levels of HBV DNA were detected in individuals with TT genotypes. Additionally, the frequency of CC genotype was higher in the active CHB patients compared with that of the inactive CHB patients (p = 0.044). No statistically significant difference in TLR 3 1377C/T polymorphism was detected between healthy controls and the hepatitis B patients (p = 0.342). In conclusion, HBV DNA level was higher in the individuals with TT genotype, and CC genotype was more frequent in the active CHB patients. These results suggest a possible association between CHB and TLR 3 gene (1377C/T) polymorphism.

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Section: Discussionmentioning

confidence: 98%

Investigation of 1377C/T polymorphism of the Toll-like receptor 3 among patients with chronic hepatitis B

et al. 2016

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“…The specific reasons for study exclusion and inclusion are described in Figure 1 . Thus, 8 articles were included in the final analysis, 9 – 16 providing 3547 cases and 2797 controls. Asian subjects were used in most studies (62.5%, n = 5).…”

Section: Resultsmentioning

confidence: 99%

“… 11 Unlike the aforementioned analyses, Sa et al showed the absence of an association between TLR3 polymorphisms and susceptibility to HBV and HCV infection in 109 cases and 299 healthy controls of South American descent. 16 Different sample sizes are a possible explanation for the conflicting results. Another important reason may relate to ethnicity variance.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple SNPs positioned in the TLR3 gene, especially those under investigation (rs1879026, rs3775296, rs3775291, rs5743305), have been targeted to assess the risk of HBV-, HCV infection, and related diseases. 9 – 16 But the results are inconsistent. The objective of this study was to examine the associations between TLR3 and risk of HBV infection, HCV infection, and HBV-related diseases by means of meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

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Toll-Like Receptor 3 is Associated With the Risk of HCV Infection and HBV-Related Diseases

Geng

Song

et al. 2016

Medicine

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There are inconsistent data on the association of risk of hepatitis virus infection and hepatitis virus-related diseases with the toll-like receptor 3 (TLR3) gene.Several common polymorphism sites were targeted to assess the risk of HBV infection, HCV infection, and HBV-related diseases.Meta-analysis combining data for 3547 cases and 2797 controls from 8 studies was performed in this study. Pooled ORs were calculated to measure the risk of hepatitis virus infection and hepatitis virus-related diseases. Fixed-effects pooled ORs were calculated using the Mantel-Haenszel method.The TLR3 gene was associated with a significantly increased risk of HBV-related diseases among 1355 patients and 1130 controls ([pooled OR, [95%CI]: 1.30, [1.15–1.48] for dominant; 1.77, [1.35–2.31] for recessive; 1.28 [1.16–1.41] for allele frequency). Subgroup analyses by a polymorphism site indicated an increased risk of HCV infection in relation to the TT/CT genotypes of rs3775291 (1.50 [1.11–2.01]), and a decreased risk ascribed to the T allele (0.20 [0.16–0.25]). We also noted an association between rs3775291 and significantly increased risk of HBV-related diseases (2.23 [1.55–3.21]). No significant inter-study heterogeneity or publication bias was detected in the analyses.These data suggest a likely effect on the risk to infect HCV and develop HBV-related diseases for the TLR3 gene. Large-scale studies with racially diverse populations are required to validate these findings.

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“…Multiple SNPs positioned in the TLR3 gene targeted to assess the risk of HCV infection have yielded inconsistent results. Indeed, Sá et al, 2015, demonstrated that the rs5743305 and rs3775291 SNPs were not associated with a risk for HCV infection [32]. This was inconsistent with a study by Medhi et al, 2011, that analyzed polymorphisms at the promoter region of the TLR3 gene [33], as well as a recent meta-analysis that concluded TLR3 gene polymorphisms (mainly rs3775291) were associated with a risk for HCV infection [34].…”

Section: Discussionmentioning

confidence: 99%

Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection

Al-Anazi

Matou‐Nasri

Abdo

et al. 2017

Journal of Immunology Research

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Toll-like receptor 3 (TLR3) plays a key role in innate immunity by recognizing pathogenic, double-stranded RNAs. Thus, activation of TLR3 is a major factor in antiviral defense and tumor eradication. Although downregulation of TLR3 gene expression has been mainly reported in patients infected with hepatitis C virus (HCV), the influence of TLR3 genotype on the risk of HCV infection, HCV-related cirrhosis, and/or hepatocellular carcinoma (HCC) remains to be determined. Single-nucleotide polymorphisms (SNPs) within the TLR3 gene and their associations with HCV-related disease risk were investigated in a Saudi Arabian population in this study. Eight TLR3 SNPs were analyzed in 563 patients with HCV, which consisted of 437 patients with chronic HCV infections, 88 with HCV-induced liver cirrhosis, and 38 with HCC. A total of 599 healthy control subjects were recruited to the study. Among the eight TLR3 SNPs studied, the rs78726532 SNP was strongly associated with HCV infection when compared to that in healthy control subjects. The rs5743314 was also strongly associated with HCV-related liver disease progression (cirrhosis and HCC). In summary, these results indicate that distinct genetic variants of TLR3 SNPs are associated with HCV infection and HCV-mediated liver disease progression in the Saudi Arabian population.

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Toll-like receptor 3 gene polymorphisms are not associated with the risk of hepatitis B and hepatitis C virus infection

Cited by 12 publications

References 20 publications

Investigation of 1377C/T polymorphism of the Toll-like receptor 3 among patients with chronic hepatitis B

Investigation of 1377C/T polymorphism of the Toll-like receptor 3 among patients with chronic hepatitis B

Toll-Like Receptor 3 is Associated With the Risk of HCV Infection and HBV-Related Diseases

Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection

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