Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and typhoid susceptibility in Asian Malay population in Malaysia

Bhuvanendran, Saatheeyavaane; Hussin, Hani Mat; Meran, Lila P.; Anthony, Amy Amilda; Zhang, Leilei; Burch, Lauranell H.; Phua, Kia Kien; Ismail, Asma; Balaram, Prabha

doi:10.1016/j.micinf.2011.04.007

Cited by 12 publications

(13 citation statements)

References 39 publications

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“…Combined effects were also calculated for all Gram negative infections [30,31,33,35,39,46,47,52,53,57-60], all Gram positive infections [43,45,46] and all parasitic infections [36,37,40,50,51,54-56] (table 3). A significant risk was found for all parasitic infections combined (OR G 1.59; 95% CI 1.05-2.42, effect derived from Asian, African and South American populations; Figure 1) and malaria (OR G 1.31; 95% CI 1.04-1.66, a combined effect for African and Asian studies; Figure 2) .…”

Section: Resultsmentioning

confidence: 99%

“…Effects on tuberculosis remained insignificant across Indian [78,81] (OR G 1.34; 95% CI 0.62-2.90) or S. American [80,82] populations (OR G 1.30; 95% CI 0.39-4.33). For outcomes with a single available study, a significant risk was present for brucellosis (OR G 2.66; 95% CI 1.66-4.27) [30], cutaneous leishmaniasis (OR G 7.22; 95% CI 1.91-27.29) [36], neurocysticercosis (OR G 4.39; 95% CI 2.53-7.61) [40], and typhoid fever (OR G 2.51; 95% CI 1.18-5.34) [47]. All the significant single-study effects are summarized in Table 4.…”

Section: Resultsmentioning

confidence: 99%

“…Specifically, the combined effects were OR G 1.30 (95% CI 0.64-2.65) for malaria, OR G 0.78 (95% CI 0.42-1.65) for aggressive and OR G 1.12 (0.83-1.52) for chronic periodontitis, and OR G 1.07 (95% CI 0.81-1.42) for tuberculosis. Effects were also insignificant for all Gram negative infections combined [OR G 1.11 (95% CI 0.66-1.87)][33,35,39,46,47,52], all Gram positive infections combined [OR G 1.09 (95% CI 0.13-9.09)] [45,46] and all parasitic infections combined [OR G 1.50 (95% CI 0.88-2.56)] [36,37,40,50,51,55,56]. The meta-analysis results are summarized in Table 3.…”

Section: Resultsmentioning

confidence: 99%

“…For outcomes with a single available study, a significant risk was present for cutaneous leishmaniasis in Iran (OR G 10.14; 95% CI 1.90-54.16) [36], neurocysticercosis in India (OR G 3.10; 95% CI 1.45-6.67) [40], S. pyogenes tonsillar disease in Greece (OR G 3.12; 95% CI 1.36-7.13) [46] and typhoid fever in Malaysia (OR G 2.26; 95% CI 1.01-5.07) [47]. A significant protection was conferred for bacterial vaginosis in pregnancy (OR G 0.55;95% CI 0.31-0.98) in the United States (notably, African Americans comprised 78% of the cases) [86], leprosy in East Africa (OR G 0.23; 95% CI 0.10-0.55) [38], and Haemophilus influenzae tonsillar disease in a Greek pediatric population (OR G 0.42; 95% CI 0.17-1.00) [46].…”

Section: Resultsmentioning

confidence: 99%

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The Role of TLR4 896 A>G and 1196 C>T in Susceptibility to Infections: A Review and Meta-Analysis of Genetic Association Studies

et al. 2013

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BackgroundToll-like receptor 4 plays a role in pathogen recognition, and common polymorphisms may alter host susceptibility to infectious diseases. PurposeTo review the association of two common polymorphisms (TLR4 896A>G and TLR4 1196C>T) with infectious diseases.Data SourcesWe searched PubMed and EMBASE up to March 2013 for pertinent literature in English, and complemented search with references lists of eligible studies.Study SelectionWe included all studies that: reported an infectious outcome; had a case-control design and reported the TLR4 896A>G and/or TLR4 1196C>T genotype frequencies; 59 studies fulfilled these criteria and were analyzed.Data ExtractionTwo authors independently extracted study data.Data SynthesisThe generalized odds ratio metric (ORG) was used to quantify the impact of TLR4 variants on disease susceptibility. A meta-analysis was undertaken for outcomes reported in >1 study. Eleven of 37 distinct outcomes were significant. TLR4 896 A>G increased risk for all parasitic infections (ORG 1.59; 95%CI 1.05-2.42), malaria (1.31; 95%CI 1.04-1.66), brucellosis (2.66; 95%CI 1.66-4.27), cutaneous leishmaniasis (7.22; 95%CI 1.91-27.29), neurocysticercosis (4.39; 95%CI 2.53-7.61), Streptococcus pyogenes tonsillar disease (2.93; 95%CI 1.24-6.93) , typhoid fever (2.51; 95%CI 1.18-5.34) and adult urinary tract infections (1.98; 95%CI 1.04-3.98), but was protective for leprosy (0.36; 95%CI 0.22-0.60). TLR4 1196 C>T effects were similar to TLR4 896 A>G for brucellosis, cutaneous leishmaniasis, leprosy, typhoid fever and S. pyogenes tonsillar disease, and was protective for bacterial vaginosis in pregnancy (0.55; 95%CI 0.31-0.98) and Haemophilus influenzae tonsillar disease (0.42; 95%CI 0.17-1.00). The majority of significant associations were among predominantly Asian populations and significant associations were rare among European populations.ConclusionsDepending on the type of infection and population, TLR4 polymorphisms are associated with increased, decreased or no difference in infectious disease. This may be due to differential functional expression of TLR4, the co-segregation of TLR4 variants or a favorable inflammatory response.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The Role of TLR4 896 A>G and 1196 C>T in Susceptibility to Infections: A Review and Meta-Analysis of Genetic Association Studies

et al. 2013

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“…Indo-European populations are frequently (6–14%) double heterozygous for both polymorphisms (Ferwerda et al, 2007), and TLR4 rs4986790/ TLR4 rs4986791 haplotype may not functionally differ from wild type TLR4. Conversely, TLR4 rs4986790 was frequently found (10–18%) among African populations, with only 2% having TLR4 rs4986791 co-segregation (Bochud et al, 2009; Bhuvanendran et al, 2011). Disparities between Europeans (co-segregation) compared to Asian and African populations (lack of co-segregation) may explain the significant associations noted for endemic diseases in Asia and Africa.…”

Section: Tlr4 Polymorphismsmentioning

confidence: 98%

Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract

et al. 2017

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The fundamental role of human Toll-like receptors (TLRs) and NOD-like receptors (NLRs), the two most studied pathogen recognition receptors (PRRs), is the protection against pathogens and excessive tissue injury. Recent evidence supports the association between TLR/NLR gene mutations and susceptibility to inflammatory, autoimmune, and malignant diseases. PRRs also interfere with several cellular processes, such as cell growth, apoptosis, cell proliferation, differentiation, autophagy, angiogenesis, cell motility and migration, and DNA repair mechanisms. We briefly review the impact of TLR4 and NOD1/NOD2 and their genetic variability in the process of inflammation, tumorigenesis and DNA repair, focusing in the gastrointestinal tract. We also review the available data on new therapeutic strategies utilizing TLR/NLR agonists and antagonists for cancer, allergic diseases, viral infections and vaccine development against both infectious diseases and cancer.

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Enterobacteria and host resistance to infection

et al. 2018

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Enterobacteriaceae are a large family of Gram-negative, non-spore-forming bacteria. Although many species exist as part of the natural flora of animals including humans, some members are associated with both intestinal and extraintestinal diseases. In this review, we focus on members of this family that have important roles in human disease: Salmonella, Escherichia, Shigella, and Yersinia, providing a brief overview of the disease caused by these bacteria, highlighting the contribution of animal models to our understanding of their pathogenesis and of host genetic determinants involved in susceptibility or resistance to infection.

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Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and typhoid susceptibility in Asian Malay population in Malaysia

Cited by 12 publications

References 39 publications

The Role of TLR4 896 A>G and 1196 C>T in Susceptibility to Infections: A Review and Meta-Analysis of Genetic Association Studies

The Role of TLR4 896 A>G and 1196 C>T in Susceptibility to Infections: A Review and Meta-Analysis of Genetic Association Studies

Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract

Enterobacteria and host resistance to infection

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