Toll-like receptor 9 and vascular endothelial growth factor levels in human kidneys from lupus nephritis patients

Frieri, Marianne; Samih, Mohammad A; Dzhindzhikhashvili, Megi; Liu, Hui; Balsam, Leah; Rubinstein, Sofia

doi:10.5301/jn.5000091

Cited by 27 publications

(21 citation statements)

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“…In a study by Frieri et al, vascular endothelial growth factor (VEGF) expression in the renal tissues of eight LN patients was compared with a healthy control group. Their results showed a significant increase in VEGF expression in the LN group [21]. Similarly, Ding et al measured VEGF levels in 41 LN patients and found higher blood and urinary VEGF levels in the LN group [22].…”

Section: Discussionmentioning

confidence: 97%

Assessment of Renal Pathological Changes in Lupus Nephritis Using Diffusion Weighted Imaging: A Multiple Correspondence Analysis

Zhao

Yan

Jia

et al. 2018

Kidney Blood Press Res

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Background/Aims: Renal pathological changes affect the motion of water molecules, which can be detected using diffusion-weighted imaging (DWI). The current study was performed to explore the correlation between renal tissue pathological injuries and DWI iconographical parameters in lupus nephritis (LN). Methods: Twenty adult patients with LN and 11 healthy volunteers were recruited. Patients with LN received renal biopsies and renal DWI-MRI inspections. The renal biopsy tissues were characterized based on the ISN/RPS 2003 classification. The volunteers, who were of comparable gender and age, only underwent renal DWI-MRI inspection. Four DWI parameters, namely, apparent diffusion coefficient (ADC), pure diffusion coefficient (D_t), pseudo-diffusion coefficient (D_p), and perfusion fraction (f_p), were calculated using monoexponential and biexponential functions, respectively. Data from different renal areas and pathological pattern groups were compared. Multiple correspondence analysis (MCA) was performed to explore the correlation between each DWI index and multiple pathological features. Results: ADC, D_t, and f_p values were lower in the LN group compared to the controls (P < 0.001) regardless of the renal area in the cortex and medulla. D_p values were higher in the LN group (P = 0.004). A difference in mean DWI parameters was found between three LN subgroups and the healthy volunteers, with the exception of the D_p index in the renal cortex. MCA showed that serious proliferative pathological injuries and lower ADC and D_t values were located in the same quadrant. The MCA plots of D_p and f_p provided similar results. Higher D_p and f_p values were located in the MCA plot quadrant with more serious proliferative pathological changes. Conclusion: DWI is a noninvasive technique that may be used to detect renal pathophysiological changes. Renal cell proliferation and intestinal fibrosis may impact the movement of water in certain microenvironments. Enhanced perfusion may be a compensatory mechanism that is associated with renal pathological injuries.

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Section: Discussionmentioning

confidence: 97%

Assessment of Renal Pathological Changes in Lupus Nephritis Using Diffusion Weighted Imaging: A Multiple Correspondence Analysis

Zhao

Yan

Jia

et al. 2018

Kidney Blood Press Res

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“…NF-κB has a direct role with many different diseases such as sepsis, HIV [15,16] hypogammaglobulinemia [17], rhinosinusitis [18], rheumatoid arthritis, systemic lupus erythematosis [19], and lupus nephritis [20]. BTKdependent activation in hypogammaglobulinemia is related to NF-κB, essential for reprogramming the expression of genes that control B cell survival and proliferation [17] and D Pteronyssinusi-induced apoptosis-related rhinosinusitis can occur [18].…”

Section: Introductionmentioning

confidence: 99%

“…BTKdependent activation in hypogammaglobulinemia is related to NF-κB, essential for reprogramming the expression of genes that control B cell survival and proliferation [17] and D Pteronyssinusi-induced apoptosis-related rhinosinusitis can occur [18]. Toll-like receptor (TLR) can activate immune-mediated glomerulonephritis and VEGF levels in human kidneys from lupus nephritis patients [20]. The cytosolic domains of TLR recruit adaptor proteins and initiate signaling pathways in response to ligand binding and myeloid differentiation factor 88 (MyD88)-dependent pathway can lead to activation of the NF-B [20].…”

Section: Introductionmentioning

confidence: 99%

“…Toll-like receptor (TLR) can activate immune-mediated glomerulonephritis and VEGF levels in human kidneys from lupus nephritis patients [20]. The cytosolic domains of TLR recruit adaptor proteins and initiate signaling pathways in response to ligand binding and myeloid differentiation factor 88 (MyD88)-dependent pathway can lead to activation of the NF-B [20].…”

Section: Introductionmentioning

confidence: 99%

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Role of Nuclear Factor-ĸB in Breast and Colorectal Cancer

Zubair¹,

Frieri

2012

Curr Allergy Asthma Rep

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The purpose of this review article is to highlight articles and new research regarding the link between NF-ĸB and several cancers. This review presents the most up-to-date NF-ĸB research and how it links this important transcription factor with hematology and oncology. It was written by conducting a thorough search of Pubmed as well as several journals such as Cancer, Nature, Science, Cell and those of one of the authors. The articles relating to the link between NF-ĸB and cancer were used to write this review. The results of this study clarified that there is a critical link between NF-ĸB and cancer. NF-ĸB has often been implicated in a variety of different diseases and it plays a variety of roles in cell survival, differentiation, and proliferation of cells. In cancer, NF-ĸB plays a pivotal role by facilitating oncogenesis as well as metastasis. A thorough understanding of NF-ĸB and its role in cancer can lead to future studies and drug development which could provide a novel option in the treatment of this disease.

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“…A cross-sectional study including 20 patients suggested that vanin-1 level in peripheral blood may be a promissory biomarker for LN and warrants further validation in a larger cohort [70]. Other cytokines and chemokines have been proved to be associated with LN, including VEGF [71] and higher levels of IL-18 and IFNγ [72]. Increased levels of macrophage inflammatory protein-1α (CCL3), MCP-1, RANTES and IFNγ-induced protein-10 are also observed in the serum of SLE patients [73].…”

Section: Profiling Protein Biomarkers In Lnmentioning

confidence: 99%

Biomarker Profiling for Lupus Nephritis

Fang

2013

Genomics, Proteomics &Amp; Bioinformatics

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Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE), which is associated with significant morbidity and mortality of SLE patients. The pathogenesis of LN involves multiple factors, including genetic predisposition, epigenetic regulation and environmental interaction. Over the last decade, omics-based techniques have been extensively utilized for biomarker screening and a wide variety of variations which are associated with SLE and LN have been identified at the levels of genomics, transcriptomics and proteomics. These studies and discoveries have expanded our understanding of the molecular basis of the disease and are important for identification of potential therapeutic targets for disease prediction and early treatment. In this review, we summarize some of the recent studies targeted at the identification of LN-associated biomarkers using genomics and proteomic approaches.

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Toll-like receptor 9 and vascular endothelial growth factor levels in human kidneys from lupus nephritis patients

Abstract: This is the first study that investigated combined expression of TLR9 and VEGF, which could be an important tool for understanding the role of TLR9 and VEGF in LN, with insights into the early detection and targeted treatment of this disease.

Cited by 27 publications

References 0 publications

Assessment of Renal Pathological Changes in Lupus Nephritis Using Diffusion Weighted Imaging: A Multiple Correspondence Analysis

Assessment of Renal Pathological Changes in Lupus Nephritis Using Diffusion Weighted Imaging: A Multiple Correspondence Analysis

Role of Nuclear Factor-ĸB in Breast and Colorectal Cancer

Biomarker Profiling for Lupus Nephritis

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