Toll-like receptor (TLR)7 expression in mycosis fungoides and psoriasis: a case-control study

Tawdy, Amira El; Amin, Iman M.; Hay, Rania Abdel; Hassan, Amr; Gad, Zeiad; Rashed, Laila Ahmed

doi:10.1111/ced.13008

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…Furthermore, immunohistochemical staining revealed that TLR4 expression was upregulated in samples from patients with guttate psoriasis compared with samples from individuals with plaque psoriasis or normal skin [29]. The level of TLR7 mRNA in lesional skin from patients with psoriasis was significantly higher than that in healthy controls [30]. Real-time polymerase chain reaction (PCR) revealed that the expression levels of TLR3, TLR5, TLR6, TLR7, TLR9, and TLR10 in lesional skin were higher than those in peripheral blood mononuclear cells (PBMCs) of the same patients with psoriasis [31].…”

Section: Tlr Signaling and Psoriasismentioning

confidence: 94%

Role of interferon regulatory factor-mediated signaling in psoriasis

2021

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Psoriasis is a chronic inflammatory disease that involves both the innate and adaptive immune systems. Type I interferons (IFNs), the production of which is partially regulated by toll-like receptors (TLRs), play an important role in the pathogenesis of psoriasis, especially psoriasis caused by skin trauma, known as the Koebner phenomenon. IFN regulatory factors (IRFs) function in both innate and adaptive immune responses, and their effect is associated with the regulation of type I IFNs. In this review, we focus on recent advances in understanding the expression of TLRs, IRFs, and type I IFNs in psoriasis. We also highlight the interplay among TLRs, IRFs, and type I IFNs.

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Section: Tlr Signaling and Psoriasismentioning

confidence: 94%

Role of interferon regulatory factor-mediated signaling in psoriasis

2021

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“…61 Notably, TLR2 and TLR7 also manifested an upregulation in the skin of individuals with psoriasis. 62,63 These revelations suggest that TLRs, specifically TLR3, TLR2 and TLR7, expressed in KCs, contribute to regulating pruritic skin diseases.…”

Section: Toll-like Receptorsmentioning

confidence: 99%

The involvement of keratinocytes in pruritus of chronic inflammatory dermatosis

Lin,

Liu,

Jiang

et al. 2024

Experimental Dermatology

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Frequent itching and incessant scratching are commonly observed in various chronic inflammatory skin conditions, including atopic dermatitis and psoriasis. The persistent and prolonged nature of pruritus can worsen one's quality of life. Keratinocytes (KCs), the predominant cells of the epidermis, have been confirmed to interact with sensory neurons and immune cells and be involved in chronic skin inflammatory diseases associated with pruritus. Initially, KCs and sensory neurons form a unique synapse‐like connection within the epidermis, serving as the structural foundation for their interaction. Additionally, several receptors, including toll‐like receptors and protease‐activated receptor 2, expressed on KCs, become activated in an inflammatory milieu. On the one hand, activated KCs are sources of pro‐inflammatory cytokines and neurotrophic factors, such as adenosine triphosphate, thymic stromal lymphopoietin, and nerve growth factor, which directly or indirectly participate in stimulating sensory neurons, thereby contributing to the itch sensations. On the other hand, KCs also function as primary transducers alongside intraepidermal nerve endings, directly initiating pruritic responses. This review summarizes the current literature and highlights the critical role of KCs in the development and persistence of chronic itch in inflammatory skin disorders.

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“…Toll-like receptors (TLRs) are a class of pattern-recognition receptors comprising more than 10 surface receptors important for pathogen recognition. The signaling mediated through TLRs and subsequent induction of cytokine release are important in various skin pathologies including MF ( 115 , 116 ). Treatment with TLR9 stimulators such as cytosine-phosphate-guanine (CpG) and oligodeoxynucleotides induces Th1-inducing cytokines, which have been proven to be clinically significant in MF and SS subjects ( 115 , 117 , 118 ).…”

Section: Tumor Microenvironment Of T-cell Lymphoma and The Role Of Cy...mentioning

confidence: 99%

Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment

Yadav,

Uikey,

Rathore

et al. 2023

Front. Oncol.

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T cells are an important component of adaptive immunity and T-cell-derived lymphomas are very complex due to many functional sub-types and functional elasticity of T-cells. As with other tumors, tissues specific factors are crucial in the development of T-cell lymphomas. In addition to neoplastic cells, T- cell lymphomas consist of a tumor micro-environment composed of normal cells and stroma. Numerous studies established the qualitative and quantitative differences between the tumor microenvironment and normal cell surroundings. Interaction between the various component of the tumor microenvironment is crucial since tumor cells can change the microenvironment and vice versa. In normal T-cell development, T-cells must respond to various stimulants deferentially and during these courses of adaptation. T-cells undergo various metabolic alterations. From the stage of quiescence to attention of fully active form T-cells undergoes various stage in terms of metabolic activity. Predominantly quiescent T-cells have ATP-generating metabolism while during the proliferative stage, their metabolism tilted towards the growth-promoting pathways. In addition to this, a functionally different subset of T-cells requires to activate the different metabolic pathways, and consequently, this regulation of the metabolic pathway control activation and function of T-cells. So, it is obvious that dynamic, and well-regulated metabolic pathways are important for the normal functioning of T-cells and their interaction with the microenvironment. There are various cell signaling mechanisms of metabolism are involved in this regulation and more and more studies have suggested the involvement of additional signaling in the development of the overall metabolic phenotype of T cells. These important signaling mediators include cytokines and hormones. The impact and role of these mediators especially the cytokines on the interplay between T-cell metabolism and the interaction of T-cells with their micro-environments in the context of T-cells lymphomas are discussed in this review article.

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Toll-like receptor (TLR)7 expression in mycosis fungoides and psoriasis: a case-control study

Cited by 9 publications

References 26 publications

Role of interferon regulatory factor-mediated signaling in psoriasis

Role of interferon regulatory factor-mediated signaling in psoriasis

The involvement of keratinocytes in pruritus of chronic inflammatory dermatosis

Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment

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