Toll-like receptors and graft rejection

Liu, Guangwei; Wu, You; Shou-liang, Gong; Zhao, Yong

doi:10.1016/j.trim.2006.03.006

Cited by 12 publications

(10 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TLRs mediate recognition of several microbial products. Accumulating evidences have demonstrated that TLRs are capable of inducing distinct responses in macrophages and other types of APCs, and subsequently direct T-helper cell differentiation in different directions (Liu et al, 2005b(Liu et al, , 2006. Thus, the levels of TLR expressions on the unstimulated Balb/c or C57BL/6 F4/80 þ PEMs and SPMs were directly determined by FCM in this study, as described in Materials and Methods.…”

Section: The Phenotypes Of Mouse F4/80mentioning

confidence: 90%

The macrophage heterogeneity: Difference between mouse peritoneal exudate and splenic F4/80⁺ macrophages

Liu

Xia

Shouliang

et al. 2006

Journal Cellular Physiology

Self Cite

View full text Add to dashboard Cite

Macrophages isolated from various tissues manifest differences in cell shape, the expression of surface markers, as well as metabolic and functional activities. However, the heterogeneity of macrophages expressing the same marker in different tissues has not been fully addressed. In the present study, mouse F4/80+ peritoneal exudate macrophages (PEMs) and splenic macrophages (SPMs) appeared similar in most respects. But the percentages of cells expressing CD80, CD40, MHC-II, TLR2, or TLR4, but not CD11c, CD54, or CD23, in freshly isolated F4/80+ SPMs were significantly higher than those in PEMs, whereas the levels of CD86+ cells in F4/80+ SPMs were markedly lower than those in PEMs. After lipopolysaccharide (LPS) stimulation, F4/80+ SPMs expressed significantly higher levels of CD86, CD40, or MHC-II than F4/80+ PEMs, but not CD11c, CD80, CD54, or CD23. F4/80+ SPMs had remarkably lower non-opsonic phagocytotic capacity against chicken RBCs or allo-T cells than PEMs as determined by two-photon microscopes and flow cytometry. SPMs produced markedly more NO than PEMs when cultured with LPS or allo-T cells. Furthermore, SPMs exhibited stronger immunogenicity than PEMs, as determined by the ability to stimulate T cell proliferation, delayed type hypersensitivity, and IFN-gamma production. The data showed the differences between SPMs and PEMs with regard to the phenotypes, phagocytosis, and immunogenicity, which may offer important information for us to better understand the distinguished immune responses of macrophages in spleens and the peritoneal cavity.

show abstract

Section: The Phenotypes Of Mouse F4/80mentioning

confidence: 90%

The macrophage heterogeneity: Difference between mouse peritoneal exudate and splenic F4/80⁺ macrophages

Liu

Xia

Shouliang

et al. 2006

Journal Cellular Physiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…A central function of TLRs is to directly activate acute antimicrobial defence systems. TLRs are known to induce the production of antimicrobial proteins and peptides by various cell types, including cells of myeloid origin in the gut epithelium 4,41 , 66 . Activation of resident macrophages through TLRs also leads to production of various cytokines (IL‐1, IL‐6, TNF‐α, etc.)…”

Section: Tlrs Cd4+ Cd25+ Treg Cells and The Immune Responsementioning

confidence: 99%

“…It was commonly accepted that TLR‐mediated recognition of specific structures of invading pathogens initiates innate as well as adaptive immune responses via dendritic cells (DCs) or other antigen‐presenting cells (APCs) 1–3 . However, there is emerging evidence that TLR signalling participates in inflammation and immune responses that are driven by self‐, allo‐ or xeno‐antigens 4–7 . TLR signalling has been demonstrated to be involved in the immune recognition of allo‐ or xenografts and the occurrence of autoimmunity both in experimental and in clinical studies 5,8–10 .…”

Section: Introductionmentioning

confidence: 99%

Toll‐like receptors and immune regulation: their direct and indirect modulation on regulatory CD4⁺ CD25⁺ T cells

2007

Self Cite

View full text Add to dashboard Cite

Summary Regulatory CD4+ CD25+ T (Treg) cells with the ability to suppress host immune responses against self‐ or non‐self antigens play important roles in the processes of autoimmunity, transplant rejection, infectious diseases and cancers. The proper regulation of CD4+ CD25+ Treg cells is thus critical for optimal immune responses. Toll‐like receptor (TLR)‐mediated recognition of specific structures of invading pathogens initiates innate as well as adaptive immune responses via antigen‐presenting cells (APCs). Interestingly, new evidence suggests that TLR signalling may directly or indirectly regulate the immunosuppressive function of CD4+ CD25+ Treg cells in immune responses. TLR signalling may shift the balance between CD4+ T‐helper cells and Treg cells, and subsequently influence the outcome of the immune response. This immunomodulation pathway may therefore have potential applications in the treatment of graft rejection, autoimmune diseases, infection diseases and cancers.

show abstract

“…Several PRRs have been characterized in a number of different hosts, such as pathogen-resistance proteins in plants [13,14], the Drosophila Toll protein [14,15] and TLRs in Caenorhabditis elegans and mammals [15,16]. During the last decade, many microbial motifs sensed by TLRs and their impact on the induction of first-line host responses have been demonstrated [9,[16][17][18].…”

Section: Innate Immunity Initiated By Tlrsmentioning

confidence: 99%

Modulation of immune responses through direct activation of Toll-like receptors to T cells

Liu

Zhang

Zhao

2010

Clinical and Experimental Immunology

View full text Add to dashboard Cite

Toll-like receptors and graft rejection

Cited by 12 publications

References 63 publications

The macrophage heterogeneity: Difference between mouse peritoneal exudate and splenic F4/80⁺ macrophages

The macrophage heterogeneity: Difference between mouse peritoneal exudate and splenic F4/80⁺ macrophages

Toll‐like receptors and immune regulation: their direct and indirect modulation on regulatory CD4⁺ CD25⁺ T cells

Modulation of immune responses through direct activation of Toll-like receptors to T cells

Contact Info

Product

Resources

About

Toll-like receptors and graft rejection

Cited by 12 publications

References 63 publications

The macrophage heterogeneity: Difference between mouse peritoneal exudate and splenic F4/80+ macrophages

The macrophage heterogeneity: Difference between mouse peritoneal exudate and splenic F4/80+ macrophages

Toll‐like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells

Modulation of immune responses through direct activation of Toll-like receptors to T cells

Contact Info

Product

Resources

About

The macrophage heterogeneity: Difference between mouse peritoneal exudate and splenic F4/80⁺ macrophages

The macrophage heterogeneity: Difference between mouse peritoneal exudate and splenic F4/80⁺ macrophages

Toll‐like receptors and immune regulation: their direct and indirect modulation on regulatory CD4⁺ CD25⁺ T cells