Tolmetin and salicylate therapy in acute rheumatic fever: Comparison of clinical efficacy and side‐effects

Karademir, Selmin; Oğuz, Deniz; Şenocak, Filiz; Öcal, Burhan; Karakurt, Cemşit; Çabuk, Feryal

doi:10.1111/j.1442-200x.2003.01801.x

Cited by 17 publications

(20 citation statements)

References 17 publications

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“…9,12 Compared to non-aspirin NSAIDs, aspirin has a lower risk of decreasing renal blood flow and GFR and does not increase the blood pressure significantly. 25,43,44 Most of the literature indicates that aspirin alone is not associated with increased risk of kidney injury, 19,20,[45][46][47] even among heavy users to treat rheumatoid conditions, [48][49][50][51] but a few other studies have shown conflicting results. 52,53 Furthermore, high intake of non-aspirin NSAIDs was associated with a nine-fold increased risk of developing end-stage renal disease (ESRD), whereas no increased risk was observed in the frequent aspirin users.…”

Section: Potential Toxicitiesmentioning

confidence: 99%

“…60 The aspirin dose used for its cardioprotective effects is usually lower than the dose used for analgesic purposes although it is generally safe even among heavy users. [48][49][50][51] Secondly, due to the association between aspirin and Reye's syndrome, it is recommended that aspirin not be used in children and adolescents with varicella or influenza-like symptoms. 61 The incidence of Reye's syndrome is low, and withholding aspirin from children with viral illness symptoms should minimize the risk.…”

Section: Potential Toxicitiesmentioning

confidence: 99%

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Use of anti-inflammatory analgesics in sickle-cell disease

2017

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Summary What is known and objective Nonsteroidal anti-inflammatory drugs (NSAIDs) have been commonly used to treat pain in sickle cell disease (SCD), but NSAID use is associated with renal, gastrointestinal, and cardiovascular toxicities. Our objective was to evaluate the use of aspirin and non-aspirin NSAIDs in SCD. Comment Despite analgesic and anti-inflammatory benefits in SCD, non-aspirin NSAIDs are associated with renal, cardiovascular and gastrointestinal toxicities in this patient population. Aspirin may have less renal and cardiovascular toxicities. The different side effect profile of NSAIDs is related to the COX-1/COX-2 selectivity at their therapeutic doses. Individual risk factors and genetic biomarkers should be considered when selecting appropriate NSAIDs and their dose. What is new and conclusion NSAIDs have the potential to be an important component of pain regimens in SCD, but the use of NSAIDs should be individualized based on potential side effects and patient risk factors and the lowest effective dose should be prescribed with proper monitoring in patients with SCD.

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Section: Potential Toxicitiesmentioning

confidence: 99%

Section: Potential Toxicitiesmentioning

confidence: 99%

Use of anti-inflammatory analgesics in sickle-cell disease

2017

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“…Most patients benefit from tolmetin, but serious side effects can occur, which generally tend to be dose related. Therefore, it is advisable to use the lowest effective dose to minimize side effects[2]. The short plasma half-life of 30-60 min following oral dosing necessitates frequent administration of the drug in order to maintain the desired steady state levels.…”

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confidence: 99%

Effect of formulation and processing variables on the characteristics of tolmetin microspheres prepared by double emulsion solvent diffusion method

et al. 2010

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The aim of this study was to evaluate microencapsulated controlled release preparations of tolmetin sodium using ethylcellulose as a retardant material. Microspheres were prepared by using water-in-oil-in-oil (W/O1/O2) double-emulsion solvent diffusion method, using different ratios of ethylcellulose to tolmetin sodium. Span 80 was used as the droplet stabilizer and n-hexane was added to harden the microspheres. The prepared microspheres were characterized for their micromeritic properties, drug content, loading efficiency, production yield, and particle size. Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray powder diffractometry and scanning electron microscopy were used to characterize microparticles. The in vitro release studies were performed in pH 1.2 and 7.4. The prepared microspheres were spherical in shape. The drug-loaded microspheres showed near to the theoretical of entrapment and release was extended up to 24. The X-ray diffractogram and differential scanning thermographs showed amorphous state of the drug in the microspheres. It was shown that the drug: polymer ratio, stirring rate, volume of dispersing medium and surfactant influenced the drug loading, particle size and drug release behavior of the formed microparticles. The results showed that, generally, an increase in the ratio of drug: polymer (0.5:1) resulted in a reduction in the release rate of the drug which may be attributed to the hydrophobic nature of the polymer. The in vitro release profile could be modified by changing various processing and formulation parameters to give a controlled release of drug from the microparticules. The release of tolmetin was influenced by the drug to polymer ratio and particle size and was found to be diffusion and erosion controlled. The best-fit release kinetic was achieved with Peppas model.

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“…8) Anti-inflammation medicines include diclofenac, 9) ketoprofen 10) and tolmetin. 11) However, the effect of indomethacin on prenatal ductal constriction is well known, and widely prescribed non-steroidal anti-inflammatory drugs such as diclofenac can have an adverse effect and are best avoided in the third trimester of pregnancy. 9) Ketoprofen is effective and safe in treating acute painful conditions for one week.…”

mentioning

confidence: 99%

“…10) Tolmetin is safe and effective treatment for arthritic rheumatic fever patients without carditis, and can be used particularly in patients who cannot tolerate aspirin. 11) Therefore, the research of the above medicinal effects is necessary for drug discoveries.…”

mentioning

confidence: 99%

Synthesis and Structural Pattern Recognition of 5-(2'-Alkoxycarbonyl-substituted phenoxy)furfural Derivatives

Chang

2009

CHEMICAL & PHARMACEUTICAL BULLETIN

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Tolmetin and salicylate therapy in acute rheumatic fever: Comparison of clinical efficacy and side‐effects

Abstract: Tolmetin was safe and effective treatment for arthritic rheumatic fever patients without carditis. Tolmetin can be used particularly in patients who cannot tolerate aspirin.

Cited by 17 publications

References 17 publications

Use of anti-inflammatory analgesics in sickle-cell disease

Use of anti-inflammatory analgesics in sickle-cell disease

Effect of formulation and processing variables on the characteristics of tolmetin microspheres prepared by double emulsion solvent diffusion method

Synthesis and Structural Pattern Recognition of 5-(2'-Alkoxycarbonyl-substituted phenoxy)furfural Derivatives

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