Toluidine blue

Keten, Alper; Okdemir, Erdem

doi:10.1016/j.ajem.2020.03.047

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…Toluidine blue is a cationic dye from the phenothiazine family. It is a derivative of aminotoluol [41]. Concerning its use as a PS, it strongly absorbs between 620 nm and 660 nm, which is within the phototherapeutic window of 600 nm-750 nm in which the penetration of light into tissues is maximum.…”

Section: Synthetic Dyesmentioning

confidence: 99%

New Applications of Photodynamic Therapy in the Management of Candidiasis

Rodríguez-Cerdeira

Martínez‐Herrera

Fabbrocini

et al. 2021

JoF

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The most important aetiological agent of opportunistic mycoses worldwide is Candida spp. These yeasts can cause severe infections in the host, which may be fatal. Isolates of Candida albicans occur with greater frequency and variable resistance patterns. Photodynamic therapy (PDT) has been recognised as an alternative treatment to kill pathogenic microorganisms. PDT utilises a photosensitizer, which is activated at a specific wavelength and oxygen concentration. Their reaction yields reactive oxygen species that kill the infectious microorganism. A systematic review of new applications of PDT in the management of candidiasis was performed. Of the 222 studies selected for in-depth screening, 84 were included in this study. All the studies reported the antifungal effectiveness, toxicity and dosimetry of treatment with antimicrobial PDT (aPDT) with different photosensitizers against Candida spp. The manuscripts that are discussed reveal the breadth of the new applications of aPDT against Candida spp., which are resistant to common antifungals. aPDT has superior performance compared to conventional antifungal therapies. With further studies, aPDT should prove valuable in daily clinical practice.

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Section: Synthetic Dyesmentioning

confidence: 99%