Toluidine blue O photosensitizer combined with caffeic acid improves antibacterial performance by increasing the permeability of cell membrane

Gu, Xiaoxiao; Yuan, Haoyang; Li, Cailing; Xu, Lixian; Li, Shuang; Yu, Dinghua

doi:10.1016/j.colsurfb.2023.113657

Cited by 1 publication

(2 citation statements)

References 37 publications

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“…The different sample plates were inverted and incubated for 12 h at a 37° incubator. The antibacterial rate was calculated using the following formula normala ntibacterial rate 0.25em ( % ) = ( CFU control − CFU sample ) / CFU control × 100 % where CFU control represents the number of bacteria in the control group and CFU sample represents the number of bacteria in the sample group. , …”

Section: Methodsmentioning

confidence: 99%

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Photothermal and Photodynamic Synergistic Effect of the MXene/SnS₂ Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Shuai,

Long,

Sun

et al. 2024

ACS Appl. Polym. Mater.

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Bacterial infection is a severe challenge faced by artificial bone transplantation, which might cause delayed bone healing or even transplant failure. Photodynamic therapy (PDT) has garnered widespread attention as a treatment for infections due to its noninvasiveness, few side effects, and high spatiotemporal selectivity. Nevertheless, owing to the bacterial membrane obstacle, it is difficult for exogenous reactive oxygen species (ROS) to penetrate into bacteria, which leads to an unsatisfactory antibacterial effect. Herein, a heterojunction of Ti 2 C 3 nanosheets/tin disulfide (MXene/SnS 2 ) is designed, which integrates photothermal and photodynamic properties. Then, MXene/SnS 2 was incorporated into a poly-L-lactic acid powder (PLLA) matrix to fabricate an artificial bone scaffold with selective laser sintering (SLS) technology. Under near-infrared laser irradiation, SnS 2 can strengthen the near-infrared light absorption of MXene to generate local hyperthermia, thus enhancing bacterial membrane permeability. Meanwhile, MXene/SnS 2 enhances charge transfer and inhibits electron−hole pair separation, thereby generating more ROS that can penetrate the bacterial interior. The results indicated that this antibacterial strategy has effective antibacterial activity, and the antibacterial rate reached over 90%. Overall, this research presents an attractive antibacterial strategy for implant-related infection.

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Section: Methodsmentioning

confidence: 99%

“…where CFU control represents the number of bacteria in the control group and CFU sample represents the number of bacteria in the sample group. 30,31 2.8.2. Bacterial Morphologies.…”

Section: Physicochemical Characterizationsmentioning

confidence: 99%

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS₂ Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Shuai,

Long,

Sun

et al. 2024

ACS Appl. Polym. Mater.

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Toluidine blue O photosensitizer combined with caffeic acid improves antibacterial performance by increasing the permeability of cell membrane

Cited by 1 publication

References 37 publications

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS₂ Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS₂ Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

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Toluidine blue O photosensitizer combined with caffeic acid improves antibacterial performance by increasing the permeability of cell membrane

Cited by 1 publication

References 37 publications

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS2 Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS2 Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Contact Info

Product

Resources

About

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS₂ Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity

Photothermal and Photodynamic Synergistic Effect of the MXene/SnS₂ Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity