2019
DOI: 10.1097/rli.0000000000000511
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Tomoelastography Paired With T2* Magnetic Resonance Imaging Detects Lupus Nephritis With Normal Renal Function

Abstract: Objectives The aim of this study was to test multiparametric magnetic resonance imaging including blood oxygen level–dependent (BOLD) imaging by T2* mapping, magnetic resonance elastography (MRE) by tomoelastography, and diffusion-weighted imaging (DWI) for detecting nephropathy in patients with lupus nephritis (LN). Methods Forty-one subjects (25 patients with LN and 16 age- and sex-matched healthy volunteers; LN: mean age, 47.3 ± 14.8 years; 22 female… Show more

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Cited by 28 publications
(32 citation statements)
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“…Most of the data from transplanted kidneys showed that MRE values were negatively associated with eGFR and fibrosis burden. Nevertheless, as authors from recent studies suggested, to our surprise, differing from that in the liver and allografts, MRE shear stiffness decreases with worsening CKD in IgA nephropathy [15], lupus nephritis [16], and diabetic nephropathy [17]. In IgA nephropathy, which is the most commonly studied glomerular nephritis, although 16 patients with biopsy-proven IgAN were studied, the investigators found that advanced stage IgAN was associated with renal softening and restricted water diffusion [15].…”
Section: Discussionmentioning
confidence: 92%
See 1 more Smart Citation
“…Most of the data from transplanted kidneys showed that MRE values were negatively associated with eGFR and fibrosis burden. Nevertheless, as authors from recent studies suggested, to our surprise, differing from that in the liver and allografts, MRE shear stiffness decreases with worsening CKD in IgA nephropathy [15], lupus nephritis [16], and diabetic nephropathy [17]. In IgA nephropathy, which is the most commonly studied glomerular nephritis, although 16 patients with biopsy-proven IgAN were studied, the investigators found that advanced stage IgAN was associated with renal softening and restricted water diffusion [15].…”
Section: Discussionmentioning
confidence: 92%
“…Their data suggested that whole-kidney stiffness correlated with the biopsy-derived Banff fibrosis score. Nevertheless, recently, at least 3 articles from native kidneys showed that MRE values had a negative relationship with fibrosis degree in IgA nephropathy [15], lupus nephritis [16], and diabetic nephropathy [17].…”
Section: Introductionmentioning
confidence: 99%
“…Magnetic resonance elastography (MRE) measures viscoelastic shear properties of biological soft tissues in vivo using externally induced vibrations at different frequencies to capture the tissue's local harmonic response by motion‐sensitive magnetic resonance imaging (MRI). MRE has been proven to be sensitive to many diseases including liver fibrosis, 1 liver tumors, 2‐4 renal dysfunction, 5 and neuroinflammation 6 …”
Section: Introductionmentioning
confidence: 99%
“…Abdominal magnetic resonance elastography (MRE) is gaining in importance for the clinical diagnosis of a large variety of diseases that alter the mechanical properties of tissues such as liver fibrosis, 1‐5 portal hypertension, 6,7 renal dysfunction, 8‐10 and tumors 11‐14 . Since the introduction of MRE in 1995 by Muthupillai et al, 15 various MRE methods tailored for clinical examinations of the abdomen have been proposed 16 .…”
Section: Introductionmentioning
confidence: 99%
“…Published studies report multifrequency 3D MRE of abdominal organs with up to eight wave dynamics consecutively acquired at up to seven frequencies, resulting in total acquisition times exceeding 5 minutes, during which patients are allowed to breathe freely 8‐10,24,25 . The same protocol with breath‐hold acquisition would exceed 20 minutes 26 .…”
Section: Introductionmentioning
confidence: 99%