Tomographie par émission de positons en médecine interne

Bonardel, G.; Lecoules, S.; Mantzarides, Marina; Carmoi, T.; Gontier, Éric; Blade, Jean‐Sébastien; Soret, Marine; Fœhrenbach, H.; Algayres, J.-P.

doi:10.1016/j.lpm.2007.04.030

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…1–3 Currently, the vast preponderance of PET radiopharmaceuticals are based on small molecules, but their small sizes limit their functional characteristics. In contrast, nanoparticles (NPs) possess multi-functionality and flexibility of their designs and constitutions that afford a wide range of functional characteristics.…”

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confidence: 99%

⁶⁴Cu Core-Labeled Nanoparticles with High Specific ActivityviaMetal-Free Click Chemistry

et al. 2012

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A novel strategy based on metal-free click chemistry was developed for the copper-64 radiolabeling of the core in shell-crosslinked nanoparticles (SCK-NPs). Compared with Cu(I)-catalyzed click chemistry, this metal-free strategy provides the following advantages for Cu-64 labeling of the core of SCK-NPs: (1) elimination of copper exchange between non-radioactive Cu in the catalyst and DOTA-chelated Cu-64; (2) elimination of the internal “click” reactions between the azide and acetylene groups in the same NPs; and (3) increased efficiency of the “click” reaction because water soluble Cu(I) does not need to reach the hydrophobic core of the NPs. When 50 mCi Cu-64 was used for the radiolabeling, the specific activity of the radiolabelled product was 975 Ci/μmol at the end of synthesis, which represents the attachment of ca. 500 Cu-64 atoms per SCK-NP, giving in essence a 500-fold amplification of specific activity of the NP over that of the Cu-64 chelate. To the best of our knowledge, this is the highest specific activity obtained for Cu-64 labeled nanoparticles.

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confidence: 99%