Tonabersat enhances temozolomide‐mediated cytotoxicity in glioblastoma by disrupting intercellular connectivity through connexin 43 inhibition
Elena N. C. Schmidt,
Bernd O. Evert,
Barbara E. F. Pregler
et al.
Abstract:Glioblastoma cells rely on connexin 43 (Cx43)‐based gap junctions (GJs) for intercellular communication, enabling them to integrate into a widely branched malignant network. Although there are promising prospects for new targeted therapies, the lack of clinically feasible GJ inhibitors has impeded their adoption in clinical practice. In the present study, we investigated tonabersat (TO), a blood–brain‐barrier‐penetrating drug with GJ‐inhibitory properties, in regard to its potential to disassemble intercellula… Show more
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