Tongue and Lip Acceleration as a Measure of Speech Decline in Amyotrophic Lateral Sclerosis

Abstract

<b><i>Purpose:</i></b> The goal of this study was to examine the efficacy of acceleration-based articulatory measures in characterizing the decline in speech motor control due to amyotrophic lateral sclerosis (ALS). <b><i>Method:</i></b> Electromagnetic articulography was used to record tongue and lip movements during the production of 20 phrases. Data were collected from 50 individuals diagnosed with ALS. Articulatory kinematic variability was measured using the spatiotemporal index of both instantaneous acceleration and speed signals. Linear regression models were used to analyze the relationship between variability measures and intelligible speaking rate (a clinical measure of disease progression). A machine learning algorithm (support vector regression, SVR) was used to assess whether acceleration or speed features (e.g., mean, median, maximum) showed better performance at predicting speech severity in patients with ALS. <b><i>Results:</i></b> As intelligible speaking rate declined, the variability of acceleration of tongue and lip movement patterns significantly increased (<i>p</i> < 0.001). The variability of speed and vertical displacement did not significantly predict speech performance measures. Additionally, based on <i>R</i><sup>2</sup> and root mean square error (RMSE) values, the SVR model was able to predict speech severity more accurately from acceleration features (<i>R</i><sup>2</sup> = 0.601, RMSE = 38.453) and displacement features (<i>R</i><sup>2</sup> = 0.218, RMSE = 52.700) than from speed features (<i>R</i><sup>2</sup> = 0.554, RMSE = 40.772). <b><i>Conclusion:</i></b> Results from these models highlight differences in speech motor control in participants with ALS. The variability in acceleration of tongue and lip movements increases as speech performance declines, potentially reflecting physiological deviations due to the progression of ALS. Our findings suggest that acceleration is a more sensitive indicator of speech deterioration due to ALS than displacement and speed and may contribute to improved algorithm designs for monitoring disease progression from speech signals.

A multimodal approach to automated hierarchical assessment of bulbar involvement in amyotrophic lateral sclerosis

“…From the kinematic modality, both pointwise and trajectory-based measures have been derived to characterize the positioning, movement, and coordination of orofacial structures (e.g., tongue, jaw, lips). These measures, including range of motion, displacement, speed/velocity, acceleration, jerk, cumulative path, area, asymmetry, variability, and spatiotemporal coupling, provide targeted assessment of reduced, slowed, jerky, asymmetrical, irregular, and dyscoordinated orofacial motion, as well documented in the motor speech disorders literature (11,24,25,30,(34)(35)(36)(37)(38)(39)(40)(41)(42). Such speech-based acoustic and kinematic measures have shown promise for detecting clinically indiscernible subclinical bulbar involvement in ALS.…”