Oral cancer is one of the most common malignancies in the head and neck area, which can also be seen during pregnancy. This study was conducted with the aim of following the report of a case of tongue cancer diagnosed during pregnancy. In this study, a 34-year-old woman who was in the 18th week of her first pregnancy noticed an aphthous lesion on her tongue and then developed pain and swelling in her neck and mouth. After biopsy of the lesion, squamous cell carcinoma of the tongue was diagnosed. For this patient, it was decided to undergo chemotherapy and radiotherapy after cesarean section in the 33rd week of pregnancy. The treatment for the patient resulted in iodine and the malignant tumor was reduced. 3 years after the completion of the treatment and with follow-up at regular intervals, there is still no sign of disease recurrence in the individual. Therefore, in addition to more investigations in this field and obtaining more results, it seems that follow-up at regular intervals can be a suitable solution to prevent the recurrence of the disease.