Tongue necrosis secondary to mucormycosis in a diabetic patient: A first case report in Malaysia

Fattah, S.-Y.-A.-S.-A.; Hariri, Firdaus; Ngui, Romano; Husman, S I Syed

doi:10.1016/j.mycmed.2018.06.004

Cited by 9 publications

(8 citation statements)

References 15 publications

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“…Although mucormycosis is reported rarely in the localized forms, more recently, several publications have described the clinical management and outcome of mucormycosis infection in the maxillofacial region, for example, the tongue [10], palate [11], mandible [12,13], maxilla [14], and orbitomaxillary/infra-orbital [15,16] region. Therefore, mucormycosis should be considered as a possible diagnosis in case of any spontaneous soft tissue necrotic lesions of orofacial area.…”

Section: Introductionmentioning

confidence: 99%

Dental and Oral Manifestations of COVID-19 Related Mucormycosis: Diagnoses, Management Strategies and Outcomes

Janjua

Shaikh

Fareed

et al. 2021

JoF

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It has been nearly two years since the pandemic caused by the novel coronavirus disease (COVID-19) has affected the world. Several innovations and discoveries related to COVID-19 are surfacing every day and new problems associated with the COVID-19 virus are also coming to light. A similar situation is with the emergence of deep invasive fungal infections associated with severe acute respiratory syndrome 2 (SARS-CoV-2). Recent literature reported the cases of pulmonary and rhino-cerebral fungal infections appearing in patients previously infected by COVID-19. Histopathological analysis of these cases has shown that most of such infections are diagnosed as mucormycosis or aspergillosis. Rhino-orbital-cerebral mucormycosis usually affects the maxillary sinus with involvement of maxillary teeth, orbits, and ethmoidal sinuses. Diabetes mellitus is an independent risk factor for both COVID-19 as well as mucormycosis. At this point, there is scanty data on the subject and most of the published literature comprises of either case reports or case series with no long-term data available. The aim of this review paper is to present the characteristics of COVID-19 related mucormycosis and associated clinical features, outcome, diagnostic and management strategies. A prompt diagnosis and aggressive treatment planning can surely benefit these patients.

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Section: Introductionmentioning

confidence: 99%

Dental and Oral Manifestations of COVID-19 Related Mucormycosis: Diagnoses, Management Strategies and Outcomes

Janjua

Shaikh

Fareed

et al. 2021

JoF

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“…Tongue necrosis has been seen in the setting of mucormycosis in three published cases (Table 3). These three patients had conditions that resulted in immune dysfunction, predisposing them to fungal infection 6–8 . Our patient would also be considered as having immune dysfunction in the setting of SLE with history of high disease activity and long‐term steroid and MMF administration.…”

Section: Discussionmentioning

confidence: 99%

“…Giant cell arteritis, [1][2][3][4] ANCA vasculitis 5 Tongue pain, macroglossia, headache, rash, vision changes, fever, hematuria Infection Fungus, [6][7][8] The patient was started on liposomal amphotericin 3 mg/kg for antibiotic coverage but continued to have fevers and rising ferritin levels, raising concern for cytokine storm given her underlying autoimmune disease and active systemic fungal infection. The patient was also noted to have low fibrinogen <50 mg/dL (N 194-448 mg/ dL).…”

Section: Systemic Vasculitidesmentioning

confidence: 99%

Tongue necrosis as a manifestation of immune dysfunction: A complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome

Walsh

Feng

Lenert

et al. 2023

Clinical Case Reports

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“…They are also found in the hospital environment and are a known nosocomial pathogen that should not be neglected. As the pandemic is placing tremendous strain on the healthcare systems worldwide, healthcare-associated Mucormycosis (HCM) is becoming a matter of concern [17] .…”

Section: Introductionmentioning

confidence: 99%

The diversity and outcome of post-covid mucormycosis: A case report

Saad¹,

Mobarak²

2021

International Journal of Surgery Case Reports

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Introduction and importance The impact of Covid-19 pandemic on the incidence and pattern of Mucormycosis (the black fungus), has increased sharply and is featured as an epidemic within a pandemic. The majority of cases were detected at late stages, which decreases the chances of survival. Case presentation The authors present a case of an immunocompetent male patient diagnosed with left orbital apex syndrome post covid-19 infection, which necessitated orbital exenteration. He was later hospitalized in a quarantine facility and an area of skin breakdown on his left cheek was noted and surgical debridement performed. Later, He presented to our institution with left hemifacial skin loss, exposing the underlying diseased bone. A multidisciplinary team examined the patient clinically and radiographically, reaching a primitive diagnosis of secondary cutaneous Mucormycosis due to rhino-orbital Mucormycosis, with no cavernous sinus thrombosis nor cranial extension. Radical surgical and medical treatments were given and he had an uneventful recovery. Unfortunately, he died 5 days after the reconstructive surgery with Anterolateral Thigh (ALT) flap. Clinical discussion The dual effect of both (covid-19) and its' associated Mucormycosis, predispose patients to increased risk of pressure injuries including Medical device related pressure injuries. Survivors of Mucormycosis are high-risk patients, and planning their reconstruction by free flaps is challenging. However, delayed reconstruction is always recommended. Conclusion Early diagnosis and management of covid-19 associated Mucormycosis should be prioritized. Moreover, surgical debridement of necrotic tissues should not be delayed due to an unavailable or negative histopathology.

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Tongue necrosis secondary to mucormycosis in a diabetic patient: A first case report in Malaysia

Cited by 9 publications

References 15 publications

Dental and Oral Manifestations of COVID-19 Related Mucormycosis: Diagnoses, Management Strategies and Outcomes

Dental and Oral Manifestations of COVID-19 Related Mucormycosis: Diagnoses, Management Strategies and Outcomes

Tongue necrosis as a manifestation of immune dysfunction: A complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome

The diversity and outcome of post-covid mucormycosis: A case report

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