Tonic inhibition of thermoregulation in the decerebrate monkey (Saimiri sciureus)

Liu, J.C.

doi:10.1016/0014-4886(79)90237-1

Cited by 22 publications

(5 citation statements)

References 27 publications

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“…The use of decerebrate animal preparations has been reported in a variety of species, including monkeys, cats, dogs, mice, rats and rabbits (Sherrington, 1898; Liu, 1979; Clarke et al 1988; Tonkovic‐Capin et al 1998; Smith et al 2010; Meehan et al 2012). Methods employed in each species can be broadly categorized as either mechanical or ischaemic decerebration.…”

Section: Resultsmentioning

confidence: 99%

A detailed surgical method for mechanical decerebration of the rat

Dobson

Harris

2012

Experimental Physiology

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Surgical methods currently employed for the mechanical decerebration of a rat are only briefly described in the literature; hence, an information void exists for researchers wishing to adopt this technique successfully. Decerebration can lead to a high rate of mortality owing to cranial bleeding, particularly if the operator is inexperienced and uninformed. The illustrated methodology presented here describes, in detail, steps in the decerebration process and indicates effective approaches, such as reversible occlusion of a carotid artery, the combined use of tissue adhesive and haemostatic sponge, and perisurgical monitoring of blood pressure, by which to control blood loss and thus maintain mean postsurgical blood pressure within acceptable physiological parameters. By using this methodology, animal losses can be minimized, particularly in the early stages of adoption of the technique, ultimately reducing the numbers required for a study of this nature.

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Section: Resultsmentioning

confidence: 99%

A detailed surgical method for mechanical decerebration of the rat

Dobson

Harris

2012

Experimental Physiology

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mentioning

confidence: 76%

“…It was concluded, therefore, that removal of a tonic inhibitory mechanism on nonshivering thermogenesis (NST) increases body temperature through disinhibition-induced activation of the central sympathetic nervous system. It has been suggested that a tonic inhibitory mechanism of NST, similar to this rodent model, may also exist in the midbrain of adult cats, monkeys, and perhaps humans (7,15,24).Recent studies (9, 26, 27) have confirmed the above results in rats by showing that procaine, a local anesthetic, transiently increases interscapular BAT (IBAT) and rectal temperatures (T IBAT and T rec , respectively) by 1-2°C, but only when it is microinjected into the lower midbrain area that was delineated by the two brain tissue transections reported in those earlier studies. That area appears to include the nuclei of the retrorubral field (RRF) and rubrospinal tract (rs).…”

mentioning

confidence: 80%

Role of inferior olive and thoracic IML neurons in nonshivering thermogenesis in rats

Uno

Shibata

2001

American Journal of Physiology-Regulatory, Integrative and Comp

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Removal of the midbrain tonic inhibitory mechanism on nonshivering thermogenesis (NST) results in increased temperatures of the interscapular brown adipose tissue (IBAT) and rectum (T(IBAT) and T(rec), respectively) via an enhanced central sympathetic output. Because it is unlikely that neurons (primary) of the midbrain inhibitory mechanism tonically inhibit the IBAT monosynaptically, there must be secondary or tertiary neurons posterior to the midbrain. Such neurons, therefore, may increase their activity during enhanced NST after removal of the midbrain tonic inhibition. The aim of the present experiments was to localize these secondary or tertiary neurons and establish descending neuronal pathway(s) that may project to the major NST effector IBAT. T(IBAT) and T(rec) increases induced by removal of the tonic inhibition by midbrain procaine microinjections were accompanied with appearance of c-Fos-positive neurons in the inferior olive (IO) and the intermediolateral (IML) cell column of the thoracic spinal cord. Electrical stimulation of and L-glutamate microinjections into the IO increased T(IBAT) and T(rec). Midbrain procaine-induced T(IBAT) and T(rec) increases were blocked by electrolytic IO lesions. These results suggest that central thermal signals produced from the lower midbrain are transmitted to IBAT through the IO and IML and that the IO has a role in the central sympathetic functions.

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“…When medullary and spinal centers are released from this inhibition, they can and do initiate such responses. These results have been replicated in monkeys (Liu, 1979). The tonic inhibitory area in cats has been further localized by Amini-Sereshki (1977).…”

Section: Neural Organization Of Thermoregulationmentioning

confidence: 66%

The Physiological Mechanisms of Motivation

Pfaff¹

1982

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Tonic inhibition of thermoregulation in the decerebrate monkey (Saimiri sciureus)

Cited by 22 publications

References 27 publications

A detailed surgical method for mechanical decerebration of the rat

A detailed surgical method for mechanical decerebration of the rat

Role of inferior olive and thoracic IML neurons in nonshivering thermogenesis in rats

The Physiological Mechanisms of Motivation

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