Tonic, Phasic, and Integrator Components of Psychophysical Responses to Topical Capsaicin Account for Differences of Location and Sex

Lariviere, William R.; McBurney, Donald H.; Frot, Maud; Balaban, Carey D.

doi:10.1016/j.jpain.2005.06.007

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…This may relate to inherent sex differences in the capsaicin response, with females having a greater sensitivity to capsaicin. This capsaicin‐sex difference has also been reported in humans . Additionally, the male rats in both treatment groups developed mechanical hyperalgesia when tested on the operant mechanical assay, but there was no difference in response between the cocoa‐ vs. control‐diet groups.…”

Section: Discussionsupporting

confidence: 72%

Effects of cocoa‐enriched diet on orofacial pain in a murine model

Rohrs

Omoto

et al. 2017

Orthod Craniofacial Res

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Structured Abstract Objectives To investigate and discuss the effects of cocoa on orofacial pain. Setting and Sample Population The Department of Orthodontics at the University of Florida (UF). Male and female hairless rats (N=20/group) were tested. Materials and Methods Rats were tested using the Orofacial Pain Assessment Device (OPAD) before and after changing their food from the standard chow to a cocoa-enriched or control-equivalent diet. Results Male rats fed the cocoa diet had a significantly higher operant pain index when tested at 37°C as compared to control diet-fed animals. Female rats on the cocoa diet had a significantly higher pain index when tested at 18°C and 44°C, as compared to animals fed the control diet. Capsaicin-induced pain was inhibited, with cocoa-diet male rats having a significantly higher pain index than control-diet male rats and cocoa-diet female rats at both 37°C and 44°C. Cocoa-diet female rats had a significantly higher pain index at 44°C than control-diet females. Mechanical sensitivity was affected following capsaicin cream, with a significantly decreased tolerated bottle distance in both cocoa- and control-diet animals, but there was no difference between cocoa- and control-diet groups. Conclusion Using the OPAD operant system, we demonstrated that a diet rich in cocoa was effective in inhibiting neurogenic inflammatory pain in rats. This has implications for the use of novel alternative therapies such as diet modification for pain control.

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Section: Discussionsupporting

confidence: 72%

Effects of cocoa‐enriched diet on orofacial pain in a murine model

Rohrs

Omoto

et al. 2017

Orthod Craniofacial Res

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“… 90 Furthermore, variants implicated in the present phenotype have been found in the genes coding for GTP cyclohydrolase 1 ( GCH1 ), 8 for the melanocortin 1 receptor ( MC1R ) 16 or for the vasopressin receptor 1A ( AVPR1A ). 53 Furthermore, nongenetic factors play a role 40 up to the estimate that only 26% of the variance in heat pain responses can be explained by genetic factors. 29 …”

Section: Discussionmentioning

confidence: 99%

Machine-learned analysis of the association of next-generation sequencing–based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin

Kringel

Geißlinger

Resch

et al. 2018

Pain

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“…For example, Frot, Feine, and Bushnell (2004) demonstrated that the same topical capsaicin stimulus to the cheek or ankle elicits a greater response over time in females than in males. In a subsequent publication (Lariviere, McBurney, Frot, & Balaban, 2005), we applied our modeling approach to these data.…”

Section: Fit Of the Model To Existing Psychophysical Datamentioning

confidence: 99%

A heuristic model of sensory adaptation

McBurney

Balaban

2009

Attention, Perception & Psychophysics

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Adaptation is a universal process in organisms as diverse as bacteria and humans, and across the various senses. This article proposes a simple, heuristic, mathematical model containing tonic and phasic processes. The model demonstrates properties not commonly associated with adaptation, such as increased sensitivity to changes, range shifting, and phase lead. Changes in only four parameters permit the model to predict empirical psychophysical data from different senses. The relatively prolonged time courses of responses to oral and topical capsaicin are used to illustrate and validate this mathematical modeling approach for different stimulus profiles. Other examples of phenomena elucidated by this modeling approach include the time courses of taste sensation, brightness perception, loudness perception, cross-adaptation to oral irritants, and cutaneous mechanoreception. It also predicts such apparently unrelated phenomena as perceived alcohol intoxication, habituation, and drug tolerance. Because the integration of phasic and tonic components is a conservative, highly efficacious solution to a ubiquitous biological challenge, sensory adaptation is seen as an evolutionary adaptation, and as a prominent feature of Mother Nature's small bag of tricks.

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Tonic, Phasic, and Integrator Components of Psychophysical Responses to Topical Capsaicin Account for Differences of Location and Sex

Cited by 6 publications

References 19 publications

Effects of cocoa‐enriched diet on orofacial pain in a murine model

Effects of cocoa‐enriched diet on orofacial pain in a murine model

Machine-learned analysis of the association of next-generation sequencing–based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin

A heuristic model of sensory adaptation

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