Tonotopic organization of the anteroventral cochlear nucleus of the cat

Bourk, Terrance R.; Mielcarz, Jane P.; Norris, Barbara E.

doi:10.1016/0378-5955(81)90008-3

Cited by 152 publications

(137 citation statements)

References 32 publications

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“…Compared with AN fibers, this transition zone is smeared out in TB fibers over a broader range of CFs and is shifted toward lower CFs: it ranged from ϳ1.4 -2.5 kHz for PL N fibers, and from 2 to 3.8 kHz for PL fibers. The downshift of the transition zone is most prominent for chopper fibers, consistent with their lower pure-tone phase-locking limit (Bourk, 1976;Rhode and Smith, 1986;Blackburn and Sachs, 1989;Winter and Palmer, 1990;Joris et al, 1994a).…”

Section: Cf Dependence Of Halfwidthmentioning

confidence: 51%

Enhanced Temporal Response Properties of Anteroventral Cochlear Nucleus Neurons to Broadband Noise

Louage¹,

Heijden²,

Joris³

2005

J. Neurosci.

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Compared with auditory nerve (AN) fibers, trapezoid body (TB) fibers of the cat show enhanced synchronization to low-frequency tones. This phenomenon probably contributes to the high temporal resolution of binaural processing. We examined whether enhanced synchronization also occurs to sustained broadband noise. We recorded responses to a reference Gaussian noise and its polarity-inverted version in the TB of barbiturate-anesthetized cats. From these we constructed shuffled autocorrelograms (SACs) and quantified spike timing by measuring the amplitude and width of their central peak.Many TB fibers with low characteristic frequency (CF) showed SACs with higher and narrower central peaks than ever observed in the AN, indicating better consistency and precision of temporal coding. Larger peaks were also observed in TB fibers with high CF, but this was mostly caused by higher average firing rates, resulting in a larger number of coincident spikes across stimulus repetitions. The results document monaural preprocessing of the temporal information delivered to binaural nuclei in the olivary complex, which likely contributes to the high sensitivity to interaural time differences.

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Section: Cf Dependence Of Halfwidthmentioning

confidence: 51%

Enhanced Temporal Response Properties of Anteroventral Cochlear Nucleus Neurons to Broadband Noise

Louage¹,

Heijden²,

Joris³

2005

J. Neurosci.

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“…The sheets have a horizontal orientation within the ventral cochlear nucleus but twist caudally to form parasagittal sheets in the DCN. These projections underlie the tonotopic organization of the resident neurons of the cochlear nucleus [19,160,191]. The data also indicate that although both divisions of the cochlear nucleus are tonotopically organized, the DCN has more tissue devoted to high frequencies compared to the VCN.…”

Section: Tonotopymentioning

confidence: 63%

“…Low-SR neurons [104,151], but intracellular recording and labeling methods directly established the tonotopic organization [171]. (Bottom) This projection was revealed to reflect the tonotopic organization of cochlear nucleus cells [19,171]. One observation from these data is that the DCN has more tissue devoted to high frequency information processing than that of the VCN.…”

Section: Sr and Peripheral Correlatesmentioning

confidence: 96%

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Primary innervation of the avian and mammalian cochlear nucleus

Ryugo¹,

Parks²

2003

Brain Research Bulletin

115

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The auditory nerve of birds and mammals exhibits differences and similarities, but given the millions of years since the two classes diverged from a common ancestor, the similarities are much more impressive than the differences. The avian nerve is simpler than that of mammals, but share many fundamental features including principles of development, structure, and physiological properties. Moreover, the available evidence shows that the human auditory nerve follows this same general organizational plan. Equally impressive are reports that homologous genes in worms, flies, and mice exert the same heredity influences in man. The clear implication is that animal studies will produce knowledge that has a direct bearing on the human condition.

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“…6, 8, 10), a region responsive to high-frequency sound (Bourk et al, 1981). A high-frequency CN region should be identified by our tests, because high frequencies (f 2 = 10 or 12 kHz) were used for the primary tones (because high frequencies elicit the largest MOC reflex in guinea pigs; Kujawa and Liberman, 1998).…”

Section: Discussion Pvcn Is the Site Of Moc Reflex Interneuronsmentioning

confidence: 99%

Medial olivocochlear reflex interneurons are located in the posteroventral cochlear nucleus: A kainic acid lesion study in guinea pigs

Venecia

Liberman

Guinan

et al. 2005

J of Comparative Neurology

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The medial olivocochlear (MOC) reflex arc is probably a three-neuron pathway consisting of type I spiral ganglion neurons, reflex interneurons in the cochlear nucleus, and MOC neurons that project to the outer hair cells of the cochlea. We investigated the identity of MOC reflex interneurons in the cochlear nucleus by assaying their regional distribution using focal injections of kainic acid. Our reflex metric was the amount of change in the distortion product otoacoustic emission (at 2f 1 -f 2 ) just after onset of the primary tones. This metric for MOC reflex strength has been shown to depend on an intact reflex pathway. Lesions involving the posteroventral cochlear nucleus (PVCN), but not the other subdivisions, produced long-term decreases in MOC reflex strength. The degree of cell loss within the dorsal part of the PVCN was a predictor of whether the lesion affected MOC reflex strength. We suggest that multipolar cells within the PVCN have the distribution and response characteristics appropriate to be the MOC reflex interneurons. Keywordshearing; outer hair cell; otoacoustic emission; superior oliveThe auditory system contains several descending pathways (Spangler and Warr, 1991), of which the best-studied is the olivocochlear (OC) efferents. OC neurons reside in the superior olivary complex and project to the cochlea (Fig. 1). The OC system is divided into two subsystems (reviewed by Warr, 1992;. Medial olivocochlear (MOC) neurons have cell bodies in the medial part of the superior olivary complex and project to outer hair cells. Lateral olivocochlear (LOC) neurons have cell bodies in or around the lateral superior olive and project to afferent fibers near inner hair cells (Warr and Guinan, 1979;Liberman, 1980;Liberman and Brown, 1986;Brown, 1987;Vetter and Mugnaini, 1992;Maison et al., 2003). Cholinergic MOC endings in the cochlea exert their effects by means of a nicotinic receptor (Vetter et al., 1999;Elgoyhen et al., 2001Elgoyhen et al., , 2003 that influences outer hair cell function and alters cochlear responses (Wiederhold and Kiang, 1970;Mountain, 1980;Siegel and Kim, 1982;Brown and Nuttall, 1984). For instance, activation of MOC neurons alters distortion product otoacoustic emissions (DPOAEs), causing rapid amplitude changes in the first several hundred milliseconds after primary-tone onset (Liberman et al., 1996;Kujawa and Liberman, 2001). The functional role of this sound-evoked feedback system may include adjusting *Correspondence to: M. Christian Brown, Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114. E-mail: mcb@epl.meei.harvard.edu. Grant sponsor: National Institute on Deafness and Other Communication Disorders; Grant number: RO1 DC 01089; Grant number: RO1 DC 00188; Grant number: P30 DC05209; Grant number: T32 DC00020-11; Grant sponsor: Triological Society. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript cochlear gain, reducing effects of masking noise, and protecting the ear from acous...

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Tonotopic organization of the anteroventral cochlear nucleus of the cat

Cited by 152 publications

References 32 publications

Enhanced Temporal Response Properties of Anteroventral Cochlear Nucleus Neurons to Broadband Noise

Enhanced Temporal Response Properties of Anteroventral Cochlear Nucleus Neurons to Broadband Noise

Primary innervation of the avian and mammalian cochlear nucleus

Medial olivocochlear reflex interneurons are located in the posteroventral cochlear nucleus: A kainic acid lesion study in guinea pigs

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