2024
DOI: 10.3389/fimmu.2024.1425455
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Tonsil explants as a human in vitro model to study vaccine responses

Elena Bonaiti,
Manuele G. Muraro,
Philippe A. Robert
et al.

Abstract: IntroductionVaccination is one of the most effective infection prevention strategies. Viruses with high mutation rates -such as influenza- escape vaccine-induced immunity and represent significant challenges to vaccine design. Influenza vaccine strain selection is based on circulating strains and immunogenicity testing in animal models with limited predictive outcomes for vaccine effectiveness in humans.MethodsWe developed a human in vitro vaccination model using human tonsil tissue explants cultured in 3D per… Show more

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