Background: Healthcare is funded and delivered separately from social care programs such as unemployment and disability insurance. Greater understanding of the health service use (HSU) of social assistance benefit recipients would support more effective design and delivery of health and social care. This study aimed to characterise the HSU of disability and unemployment benefit recipients relative to people earning wages, and to identify personal, household and health-related factors associated with HSU in disability benefit recipients.Methods: A cross-sectional national survey of 9,520 working age Australian adults in three groups: (1) 638 receiving the disability support pension (DSP); (2) 442 receiving unemployment benefits; and (3) 8440 earning wages. Outcomes included count and frequency of health professional consultations, hospital attendance and admission in the past 12 months, as well as medication and supplement use in the past 2 weeks. Analyses compared DSP and unemployment benefit recipients to wage earners using age and sex adjusted risk ratios and incident rate ratios. Negative binomial regression models were constructed to examine factors associated with hospitalisation and general practitioner services in DSP recipients. Results: DSP recipients were significantly more likely than wage earners to have consulted 15 of 22 types of health professionals, had 2.5 times greater risk and 3.8 times higher rate of hospital admission, and 3.4 times greater risk of prescription medication use. Unemployment benefit recipients were significantly more likely than wage earners to have consulted 5 of 22 types of health professionals, had 1.5 times greater risk of hospital admission and 1.2 times greater risk of prescription medication use. Younger age, hypertension, more co-morbid conditions and poorer self-assessed health were associated with higher rate of hospital admission among DSP recipients. Conclusions: People receiving unemployment and disability insurance benefits use significantly more health services than wage earners. A range of personal and clinical characteristics are associated with greater HSU among disability benefit recipients. Greater coordination between health and social care systems may improve health, reduce HSU and improve work ability in unemployed and working age people.