In industry, the capability to predict the tool point frequency response function (FRF) is an essential matter in order to ensure the stability of cutting processes. Fast and accurate identification of contact parameters in spindle-holder-tool assemblies is very important issue in machining dynamics analysis. This work is an attempt to illustrate the utility of soft computing techniques in identification and prediction contact parameters of spindle-holder-tool assemblies. In this paper, three soft computing techniques, namely, genetic algorithm (GA), simulated annealing (SA), and particle swarm optimization (PSO) were used for identification of contact dynamics in spindle-holder-tool assemblies. In order to verify the proposed identification approaches, numerical and experimental analysis of the spindle-holder-tool assembly was carried out and the results are presented. Finally, a model based on the adaptive neural fuzzy inference system (ANFIS) was used to predict the dynamical contact parameters at the holder-tool interface of a spindle-holder-tool assembly. Accuracy and performance of the ANFIS model has been found to be satisfactory while validated with experimental results.