Toonamicrocarpavarin, a new tirucallane-type triterpenoid from <i>Toona Ciliata</i>

Zhang, Ling; Xia, Jianjun; Duan, Yan-Qing; Wei, Keyi; Gao, Rui Han; Li, Dasan; Liu, Xiaomin; Zhang, Tiandong; Qiu, Ming‐Hua

doi:10.1080/14786419.2019.1627351

Cited by 9 publications

(2 citation statements)

References 20 publications

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“…Nitric oxide (NO) and tumor necrosis factor alpha (TNF-α) are the key factors released during inflammation. The anti-inflammatory activities of Limonoids are listed in table 60. The inhibitory activities on lipopolysaccharide (LPS) stimulated inflammation factor-release (NO and TNF-α) of mouse macrophages RAW 264.7 in vitro were evaluated (Table 60).…”

Section: Anti-inflammatory/potential Inhibitors Of Macrophage Activationmentioning

confidence: 99%

Chemistry and Biology of Novel Meliaceae Limonoids

Mulani

Nandikol

Thulasiram

2022

Preprint

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Nature has bestowed us with abundant bioactive/drug molecules for various uses in our everyday life. One such group of plant specialized molecules is limonoids, which are structurally characterized as 4,4,8-trimethyl-17-furanyl steroidal skeleton. Limonoids are well known for their various biological activities such as potent anti-feedent, anti-cancer, anti-inflammatory, insecticidal, anti-diabetic, anti-viral, anti-microbial etc. These tetranortriterpenes are highly oxygenated and structurally diversified molecules majorly found in Meliaceae and Rutaceae and less frequently in the Cneoraceae families in the plant kingdom. Many of these plants have been used in traditional medicine from ages. One of the well-known limonoid, azadirachtin A is highly valued and widely popular for its outstanding insecticidal properties. Till date, nearly 2500 limonoids with over 35 unique carbon frameworks have been observed. In recent times, these molecules have dig a great interest among researchers due to their myriad biological properties. With the advancement of analytical techniques, the limonoid research is aced to explore more different molecules from their sources. In our review we cover all the Meliaceous limonoids isolated during July 2010 to Dec 2020. We found over 1502 new limonoids, which are reported from various Meliaceae plants after Jun 2010. We have classified them based on their skeletal structure rearrangements and functional groups into various classes such as protolimonoids, Apoprotolionoid, Azadirone, Vilasinin, Cedrelone, Havanensin, Trichilin, Nimbin, Salannin, Azadirachtin, Nimbolidin, Nimbolinin, Obacunol, Evodulone, Trijugin, Cipadesin, Andirobin, Mexicanolide, Phragmalin, Khayanolide, Preieurianin, Aphanamixoid, Nor Limonoid and N-containing derivatives. Further we have discussed their biological activities in detail.

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Section: Anti-inflammatory/potential Inhibitors Of Macrophage Activationmentioning

confidence: 99%

Chemistry and Biology of Novel Meliaceae Limonoids

Mulani

Nandikol

Thulasiram

2022

Preprint

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“…There are many potential health benefits associated with triterpenoids, including anti-inflammatory [13][14], antioxidant [15], antibacterial [16][17], antiviral [18][19], antifungal [20][21], hepatoprotective [20][21], anti-disease Alzheimer's [21], immunomodulatory [22][23], cytotoxic [24], and anticancer [25][26]. Cedrela [25], Turraea [26], Entandrophragma [27], Azadirachta [28], Guarea [29], Lansium [30], Chisocheton [31], Melia [32], Dysoxylum [33], Toona [34], and Aglaia [35] are all examples of taxa in the Meliaceae family that contain triterpenoids.…”

Section: ■ Introductionmentioning

confidence: 99%

Triterpenoids from the Stem Bark of <i>Aglaia cucullata</i> (Meliaceae) and Their Cytotoxic Activity against A549 Lung Cancer Cell Line

Harneti,

Mustaqim,

Darwati

et al. 2023

Indones. J. Chem.

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The Aglaia species, which contains triterpenoids, is the most numerous in the Meliaceae family. The A. cucullata species, of which there are only a few known examples, has received scant research attention. This investigation aims to identify triterpenoids in an n-hexane preparation of A. cucullata stem bark and evaluate their effects against the A549 lung cancer cell line. Five dammarane-type triterpenoids were isolated from the A. cucullata trunk bark, which is (1) (20S)-20-hydroxydammar-24-en-3-one, (2) cabraleone, (3) cabralealactone, (4) eichlerianic acid, and (5) (+)-fouquierol. Their chemical structures were determined using infrared, high-resolution mass spectrometry, and nuclear magnetic resonance, as well as through data comparison of the reported compounds. Compound 1 was priorly separated from the Aglaia genus, compounds 2–4 were first isolated from the A. cucullata species, and compound 5 has been reportedly isolated from the Meliaceae family and the Aglaia genus. All substances were tested for their lethal potential against the A549 lung cancer cell type. A seco structure in the A ring of dammarane-type triterpenoid might play an important part in the lethal activity of component 4, which showed the greatest activity with an IC50 value of 32.17 µM against the A549 lung cancer cell line.

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Triterpenoids and saponins in drug discovery

Liu

Wang

et al. 2023

Privileged Scaffolds in Drug Discovery

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Toonamicrocarpavarin, a new tirucallane-type triterpenoid from Toona Ciliata

Cited by 9 publications

References 20 publications

Chemistry and Biology of Novel Meliaceae Limonoids

Chemistry and Biology of Novel Meliaceae Limonoids

Triterpenoids from the Stem Bark of <i>Aglaia cucullata</i> (Meliaceae) and Their Cytotoxic Activity against A549 Lung Cancer Cell Line

Triterpenoids and saponins in drug discovery

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