Tooth Bank System for Bone Regeneration - Safety Report -

Kim, Young-Kyun; Um, In-Woong; Murata, Masaru

doi:10.2485/jhtb.23.371

Cited by 30 publications

(34 citation statements)

References 22 publications

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“…The incidence of inflammatory responses, such as swelling at the early postoperative stage, was negligible and did not have any influences on bone formation despite some cases showing the occurrence of dehiscence. As reported previously 17) , these cases of dehiscence healed spontaneously, most likely due to the Type I collagenous nature of allogenic DDM (Table 2).…”

Section: Discussionsupporting

confidence: 76%

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Retrospective Clinical Study of Allogenic Demineralized Dentin Matrix for Alveolar Bone Repair

Kim

Bang

Murata

et al. 2017

J. Hard Tissue Biology.

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Demineralization procedure of dentin and bone is well known to reduce the antigenicity and immunogenicity of allogenic dentin matrix as well as promote inactivation of transmissible viral disease. This study aims to evaluate the effectiveness of allogenic, demineralized dentin matrix (DDM) for alveolar bone repair. Clinical findings indicate that the healing process may be as effective as that observed with autogenous DDM. From 2013 to 2016, eighteen patients who underwent socket preservation with allogenic DDM were selected for evaluation of early complications at the surgical stage and for histological evaluation during a secondary surgical procedure at the Seoul National University Bundang Hospital and Seoul In Dental Clinic. They were monitored during the initial 7 to 10 postoperative days for observing the related immune responses. Like with autogenous DDM, no remarkable early and late complications were observed to result with the use of allogenic DDM. Additionally, the effect of bone regeneration was very similar to that found with autogenous DDM. Within the limitations of this study, the clinical results of allogenic DDM were similar to those of autogenous DDM.

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Section: Discussionsupporting

confidence: 76%

“…The dentin powder was washed with distilled water; subsequently, it was freeze-dried for 3-5 hours and was sterilized (Korea Patent Number 10-1062381). The demineralized dentin powder was kept at room temperature 17) .…”

Section: Fabrication Of Allogenic Ddmmentioning

confidence: 99%

Retrospective Clinical Study of Allogenic Demineralized Dentin Matrix for Alveolar Bone Repair

Kim

Bang

Murata

et al. 2017

J. Hard Tissue Biology.

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“…Allogenic and autogenous DDMs were both derived according to the patented (Korea Patent Number: 10-1062381) method described by Kim et al 4) . Briefly, DDM powder was procured by pulverizing extracted root dentin to particles 0.3-0.8 mm in diameter, after removing the attached soft tissue and pulp.…”

Section: Fabrication Of Allogenic and Autogenous Ddmmentioning

confidence: 99%

“…After removal of the inorganic portion (demineralization), the remaining matrix could be defined as acid-insoluble collagen to which various other proteins are bound 3) . Histologically, dentin matrix consists of tubules 1-3 μm in diameter (dentinal tubules), which provide nanopore spaces that increase the surface contact area and can accommodate the rhBMP-2 solution, thereby increasing the capacity of dentin to function as an effective scaff old/carrier for rhBMP-2 [4][5][6] . With respect to using DDM as an rhBMP-2 carrier, Ike et al reported in 1998 that exogenous rhBMP-2 adsorbed into pulverized root partially demineralized dentin matrix (PDM) proved to be as osteoinductive as autogenous bone graft 7) .…”

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confidence: 99%

Histological Comparison of Autogenous and Allogenic Demineralized Dentin Matrix Loaded with Recombinant Human Bone Morphogenetic Protein-2 for Alveolar Bone Repair: A Preliminary Report

Jun

Yun

et al. 2017

J. Hard Tissue Biology.

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The goal of investigation is to examine the histological response to recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded demineralized dentin matrices (DDMs) of different origins. The evaluation site is chosen between the cover screw and gingiva, as the poor blood supply allows it to simulate a heterotopic condition. We hypothesize that the antigenicity and immunogenicity of the carrier allogenic DDMs are low enough to maintain both the biocompatibility of the scaff old and the activity of the loaded rhBMP-2. Three patients undergoing simultaneous implant placement and receiving a diff erent type of graft were included: allogenic DDM loaded with rhBMP-2(DDM/rhBMP-2), autogenous DDM/rhBMP-2 and autogenous DDM. Histological specimens were retrieved during the secondary surgery after 3-6 months. In histological examination, particles were encapsulated by dense fi brous tissue without any infl ammatory cells. The capsule contained an increased number of cell layers in the DDM/rhBMP-2 (allogenic and autogenous) compared to autogenous DDM. Resorption activity was higher in autogenous DDM/rhBMP-2 than in allogenic DDM/rhBMP-2. Within the limitations of this report, results demonstrated the successful use of DDM as a potential rhBMP2 carrier. Further studies will be required to confi rm the safety and eff ectiveness of autogenous and allogenic DDM/rhBMP-2.

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“…In addition, the geometrical similarity of ABTB to the alveolar bone has major advantages required in threedimensional scaffolds because ABTB outcontours the alveolar bone before extraction, which is needed for the site of future implants [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Autogenous Tooth Bone Graft Block For Socket Preservation: A One-Stage Technique

Kim¹,

Fajardo²,

Valera³

et al. 2017

Dentistry

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To replace the autogenous bone block graft in socket preservation technique that has disadvantages despite gold standard such as second surgery, more healing period and cost, the author introduces the surgical technique and five-year clinical outcome of using preformed autogenous tooth bone graft block (ABTB) which was fabricated from the patient's own extracted tooth, with simultaneous implant placement. Evaluations of the five-year clinical outcome were also performed with cone beam computed tomography (CBCT).ABTB is root dentin block composed of Type I collagen matrix with several osteoinductive non-collagenous proteins such as bone morphogenetic proteins (BMP) and dentin matrix proteins. Geometrically, alveolar bone morphology was maintained by ABTB as well as it has micropores (dentinal tubules) of 3-5 μm diameter and macropores of 0.2-0.3 mm diameter for enhancing osteoinductive and osteoconductive functions.Five year follow up with CBCT showed that alveolar bone volume and shape were maintained successfully which was repaired and restored by ABTB. This might become the effective technique for socket preservations given the well controlled long term follow up studies.

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Tooth Bank System for Bone Regeneration - Safety Report -

Cited by 30 publications

References 22 publications

Retrospective Clinical Study of Allogenic Demineralized Dentin Matrix for Alveolar Bone Repair

Retrospective Clinical Study of Allogenic Demineralized Dentin Matrix for Alveolar Bone Repair

Histological Comparison of Autogenous and Allogenic Demineralized Dentin Matrix Loaded with Recombinant Human Bone Morphogenetic Protein-2 for Alveolar Bone Repair: A Preliminary Report

Autogenous Tooth Bone Graft Block For Socket Preservation: A One-Stage Technique

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