Knowledge of and practice around health inequities have been limited by scarce investigations on intersecting forms of structural oppression, including the extent to which their effects are more severe among multiply marginalized groups. We address these insufficiencies by adopting a structural intersectionality approach to the study of edentulism (i.e., complete tooth loss), the dental equivalent of mortality. While individual information was gathered from approximately 200,000 adult (18-64 years) respondents of the 2010 U.S. Behavioral Risk Factor Surveillance System, state-level data for 2000 and 2010 were obtained from Homan et al.’s (2021) study, and the U.S. census. These three sources provided information on edentulism, race, gender, structural racism, structural sexism, and income inequality, in addition to multiple covariates. Analyses showed that the intersections between structural sexism, and either state-level income inequality, or structural racism were associated with 1.4 (95%CI=1.1;1.9) and 1.5 (95%CI=1.1;2.2) increased odds of complete tooth loss, respectively. Edentulism reached the highest frequency among non-Hispanic Black men, residing in states with high structural racism, high structural sexism, and high economic inequality. Based on these and other findings, we highlight the importance of a structural intersectionality approach to research and policy related to health inequities in the United States and elsewhere.