Tooth Loss and Blood Pressure in Parkinson’s Disease Patients: An Exploratory Study on NHANES Data

Lyra, Patrícia; Machado, Vanessa; Proença, Luís; Mendes, José João; Botelho, João

doi:10.3390/ijerph18095032

Cited by 14 publications

(7 citation statements)

References 56 publications

(74 reference statements)

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“…Data analyzed in this study were acquired from NHANES (1999-2018), which was designed to assess the nutritional status and health of children and adults in the United States. The program of NHANES was reviewed and approved by the Prevention National Center for Health Statistics Research (NCHS) and the Centers for Disease Control (CDC) Research Ethics Review Board (17), and all participants signed written informed consent (17).…”

Section: Study Populationmentioning

confidence: 99%

An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES

et al. 2022

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BackgroundMigraine is a common neurological disease and an important cause of disability worldwide. Serum urate is the end product of purine metabolism in Homo sapiens and other hominoids. Previous studies about the serum urate level in migraine were contradictory. Hence, we present a cross-section study to clarify the association between serum urate and migraine and explore the dose effect of serum urate on migraine.Materials and MethodsThe data for this cross-section study were acquired from the National Health and Nutrition Examination Survey (NHANES). A diagnosis of migraine was made through patient the self-reported and prescription medication. For data analysis, the weighted linear regression model, weighted chi-square test, logistic regression models, smooth curve fittings, and the two-piecewise linear regression model were utilized for data analysis. All data analysis was conducted on Empower software.ResultsTotally, 18,637 participants were enrolled in this study, of which 208 were migraineurs. The rest were set as control. There existed a statistically significant difference in mean age (p = 0.0389), gender (p< 0.0001), race (p< 0.0001), data release cycle (p = 0.048), drug usage, blood albumin (p< 0.0001), blood total protein (p< 0.0001), hemoglobin (p< 0.0001), serum iron (p< 0.0001), and serum urate (p< 0.0001) between the two groups. According to logistic regression models, there existed no consistent linear relationship between serum urate and migraine before (model 1: odd ratio (OR) = 0.83, p = 0.0004) or after adjusting for confounders (model 2: OR = 0.96, p = 0.5198; model 3: OR = 0.84, p = 0.0184). However, smooth curve fittings found an exponential curve relationship between serum urate and migraine. Furthermore, when serum urate was more than 7.8 mg/dl, higher serum urate was correlated with higher migraine occurrence (model 1: OR = 1.54, p = 0.0022; model 2: OR = 1.51, p = 0.0050; model 3: OR = 1.77, p = 0.0348). Besides, 8 out of the 208 migraineurs had a serum urate higher than 7.8 mg/dl.ConclusionsIn conclusion, there existed an exponential curve relationship between serum urate and migraine, with an infliction point of 7.8 mg/dl. When serum urate was more than 7.8 mg/dl, increased serum urate was correlated with higher migraine occurrence.

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Section: Study Populationmentioning

confidence: 99%

An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES

et al. 2022

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“…Despite the small sample number, the collected data is of clinical significance, and we hope to pave the way for future larger studies on this condition worldwide (for instance using the MDS non-motor study group network). Also, the secondary study design based on the available NHANES data has been previously applied and accepted in several recent studies, including the PD-case selection method employed 26 , 43 . Nonetheless, due to the used PD-case selection method, data on disease duration was not available, which would have been relevant to evaluate disease staging.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding ethnicity, “Mexican American”, “Other Hispanic”, “Non-Hispanic White”, “Non-Hispanic Black” and “Other race—including multi-racial” were the used designations, as indicated in the NHANES self-reported questionnaires 43 .…”

Section: Methodsmentioning

confidence: 99%

Self-reported periodontitis and C-reactive protein in Parkinson’s disease: a cross-sectional study of two American cohorts

Lyra¹,

Botelho²,

Machado³

et al. 2022

npj Parkinsons Dis.

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Periodontitis triggers systemic repercussions, such as elevated levels of high-sensitive C-reactive protein (hs-CRP). This has never been studied within Parkinson’s Disease (PD). The aim of this study is to compare hs-CRP levels of self-reported periodontitis cases versus cases without periodontitis in PD patients. Data from the National Health and Nutrition Examination Survey (2015–2016 and 2017–2018 waves) were analyzed. PD cases were identified through medication regimens and periodontitis cases through a validated self-report questionnaire. 51 participants were included (24 females, 27 males, with mean age of 62.96 (14.71)). While the self-reported periodontitis group presented elevated levels of circulating hs-CRP (5.36 vs. 1.99 mg/L, p = 0.031), the self-reported without periodontitis group presented higher lymphocyte levels (29.35 vs. 28.03%, p = 0.007). Blood levels of hs-CRP were significantly higher in PD cases with self-reported periodontitis. Apart from the lymphocyte levels, there were no other significant differences according to the self-reported periodontal status. Future studies shall explore this association using clinical measures.

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“…Many patients with PD suffered depression at the time of diagnosis. To explore whether PD was a potential covariate that affected the relationship between aMED and depressive symptom, patients suffering PD were identified amongst our participant pool (26,27). Here, PD cases were identified if clinical history was remarkable for treatment with any of the following PDspecific medications: benztropine (generic drug code: d00175), carbidopa (generic drug code: d03473), levodopa (generic drug code: d03473), ropinirole (generic drug code: d04215), methyldopa (generic drug code: d00133), entacapone (generic drug code: d04460), and amantadine (generic drug code: d00086) (26,27).…”

Section: Potential Covariatesmentioning

confidence: 99%

Non-linear association between Mediterranean diet and depressive symptom in U.S. adults: A cross-sectional study

et al. 2022

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The Mediterranean diet (MED), a dietary pattern rich in fruits and vegetables, whole grains, legumes, nuts, fish, and olive oil, has anti-oxidative and anti-inflammatory effects. Although some data suggest that MED adherence is associated with decreased manifestation of depressive symptoms, it remains necessary to further analyze this apparent non-linear association as well as the influence of different factors on the relationship between MED and depression. Here, we investigated associations between the alternate MED (aMED) score and depressive symptom via multivariate logistic regression, weighted generalized additive (GAM) and two-step linear regression models, analyzing data from the 2005–2018 National Health and Nutrition Examination Survey (NHANES). The most important factor relevant to aMED score that contributed to the prevalence of depressive symptom was assessed using random forest. Furthermore, we examined whether the relationship between aMED score and depressive symptom differs by age, race, sex, socioeconomic variables, lifestyle- and health-related variables, and chronic medical conditions, via subgroup analyses. A total of 19,477 participants (20–80 years of age) were included in this cross-sectional study. In crude and adjusted (1–5) multivariate logistic regression models, increased aMED score was noted to associate with non-depressive status, as defined using the Patient Health Questionnaire-9 (P < 0.05). Data analyses via GAM and two-piecewise linear regression revealed a non-linear association between aMED and depressive symptom, which had an inflection point of 3. Random forest results revealed that vegetable score contributes greatest to the relationship between aMED and depressive symptom. Subgroup analyses revealed that aMED score is significantly negatively related with depressive symptom in most different populations (P < 0.05) with the exception of high annual income, diabetes, borderline blood glucose level and Parkinson's disease (PD) (P > 0.05). In conclusion, we observed a non-linear association between aMED score and depressive symptom. Further studies are needed to validate our results.

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Tooth Loss and Blood Pressure in Parkinson’s Disease Patients: An Exploratory Study on NHANES Data

Cited by 14 publications

References 56 publications

An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES

An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES

Self-reported periodontitis and C-reactive protein in Parkinson’s disease: a cross-sectional study of two American cohorts

Non-linear association between Mediterranean diet and depressive symptom in U.S. adults: A cross-sectional study

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