Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies

Kim, Min-Kook; Park, Chan Ho

doi:10.3390/molecules25204802

Cited by 17 publications

(13 citation statements)

References 183 publications

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“…Recently, fabrication of 3D architectures or the chemical modifications of biopolymeric materials have shown to promote osteogenesis and cementogenesis. 50 Another approach for modification of biomaterial surface chemistry to mimic bone ECM, by coating synthetic dicalcium phosphate bioceramics with bone ECM proteins, has shown modulation of the host immune reactions and improvement in their regenerative performance. 51 A study involving periodontal defect model of beagle dogs demonstrated the surface functionalization of chitosan nanoparticles with ε-aminocaproic acid incorporated fibrin resulted in significant cementum formation on the exposed root dentin compared to fibrin-only and enamel matrix derivative (EMD) which is often used clinically to achieve periodontal regeneration.…”

Section: Role Of Surface Chemistrymentioning

confidence: 99%

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

et al. 2021

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Control of inflammation is indispensable for optimal oral wound healing and tissue regeneration. Several biomaterials have been used to enhance the regenerative outcomes; however, the biomaterial implantation can ensure an immune-inflammatory response. The interface between the cells and the biomaterial surface plays a critical role in determining the success of soft and hard tissue regeneration. The initial inflammatory response upon biomaterial implantation helps in tissue repair and regeneration, however, persistant inflammation impairs the wound healing response. The cells interact with the biomaterials through extracellular matrix proteins leading to protein adsorption followed by recruitment, attachment, migration, and proliferation of several immune-inflammatory cells. Physical nanotopography of biomaterials, such as surface proteins, roughness, and porosity, is crucial for driving cellular attachment and migration. Similarly, modification of scaffold surface chemistry by adapting hydrophilicity, surface charge, surface coatings, can down-regulate the initiation of pro-inflammatory cascades. Besides, functionalization of scaffold surfaces with active biological molecules can down-regulate pro-inflammatory and pro-resorptive mediators’ release as well as actively up-regulate anti-inflammatory markers. This review encompasses various strategies for the optimization of physical, chemical, and biological properties of biomaterial and the underlying mechanisms to modulate the immune-inflammatory response, thereby, promoting the tissue integration and subsequent soft and hard tissue regeneration potential of the administered biomaterial.

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Section: Role Of Surface Chemistrymentioning

confidence: 99%

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

et al. 2021

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“…Natural and synthetic origin biomaterials have been studied, but regeneration of periodontal defects persists to be a field with many difficulties, reporting just preliminary results and limited gain in terms of true regeneration of the support and protection apparatus [ 54 ]. Then, the use of therapies with controlled release of drugs loaded in different materials such as hydrogels, biolayers, micro, and nanofibers has been developed and has promising results [ 55 – 57 ].…”

Section: Immunomodulation With Biomaterialsmentioning

confidence: 99%

Biomaterials Used for Periodontal Disease Treatment: Focusing on Immunomodulatory Properties

Garzón

Suárez

Muñoz

et al. 2022

International Journal of Biomaterials

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The growing use of biomaterials with different therapeutic purposes increases the need for their physiological understanding as well as to seek its integration with the human body. Chronic inflammatory local pathologies, generally associated with infectious or autoimmunity processes, have been a current therapeutic target due to the difficulty in their treatment. The recent development of biomaterials with immunomodulatory capacity would then become one of the possible strategies for their management in local pathologies, by intervening in situ, without generating alterations in the systemic immune response. The treatment of periodontal disease as an inflammatory entity has involved the use of different approaches and biomaterials. There is no conclusive, high evidence about the use of these biomaterials in the regeneration of periodontitis sequelae, so the profession keeps looking for other different strategies. The use of biomaterials with immunomodulatory properties could be one, with a promising future. This review of the literature summarizes the scientific evidence about biomaterials used in the treatment of periodontal disease.

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“…In nature, collagen is one of the most abundant cellular matrix proteins [ 42 ]. It is present in the gingival epithelium.…”

Section: Chemical Classification and Biological Activity Of Natural Dental Polymersmentioning

confidence: 99%

Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives

Paradowska-Stolarz

Więckiewicz

Owczarek

et al. 2021

IJMS

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The success of modern dental treatment is strongly dependent on the materials used both temporarily and permanently. Among all dental materials, polymers are a very important class with a wide spectrum of applications. This review aims to provide a state-of-the-art overview of the recent advances in the field of natural polymers used to maintain or restore oral health. It focuses on the properties of the most common proteins and polysaccharides of natural origin in terms of meeting the specific biological requirements in the increasingly demanding field of modern dentistry. The use of naturally derived polymers in different dental specialties for preventive and therapeutic purposes has been discussed. The major fields of application cover caries and the management of periodontal diseases, the fabrication of membranes and scaffolds for the regeneration of dental structures, the manufacturing of oral appliances and dentures as well as providing systems for oral drug delivery. This paper also includes a comparative characteristic of natural and synthetic dental polymers. Finally, the current review highlights new perspectives, possible future advancements, as well as challenges that may be encountered by researchers in the field of dental applications of polymers of natural origin.

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Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies

Cited by 17 publications

References 183 publications

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

Biomaterials Used for Periodontal Disease Treatment: Focusing on Immunomodulatory Properties

Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives

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