Top down and bottom up engineering of bone

Tate, Melissa L. Knothe

doi:10.1016/j.jbiomech.2010.10.019

Cited by 48 publications

(19 citation statements)

References 75 publications

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“…All these aspects contribute to bone adaptation to loading while reaching a dynamic spatiotemporal steady state. As recently reported, the current paradigm of bone mechanical adaptation considers the bone cells as smart micromachines able not only to adapt themselves to the spatiotemporally dynamic habitat, but also to modulate the mechanical milieu through production (adaptation) of extracellular matrix (ECM) 6 . Bone adaptation also involves the peri‐implant surrounding bone, as is well documented by several studies 7‐10 …”

mentioning

confidence: 94%

Effect of Nanoscale Topography of Titanium Implants on Bone Vessel Network, Osteocytes, and Mineral Densities

Traini

Murmura

Piattelli

et al. 2013

Journal of Periodontology

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mentioning

confidence: 94%

Effect of Nanoscale Topography of Titanium Implants on Bone Vessel Network, Osteocytes, and Mineral Densities

Traini

Murmura

Piattelli

et al. 2013

Journal of Periodontology

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“…The approach exemplified by the one stage bone transport procedure has been implemented successfully in limited clinical cases where other treatment modalities were not feasible [90]. Engineering of substitute periosteum is a promising area of research that benefits from both top down perspectives as well as bottom up approaches to recreate the multiscale structure-function relationships embodied by the smart material, using nature's engineering paradigms [91]. …”

Section: Introductionmentioning

confidence: 99%

Current insights on the regenerative potential of the periosteum: Molecular, cellular, and endogenous engineering approaches

Colnot

Zhang

Tate

2012

Journal Orthopaedic Research

216

187

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While century old clinical reports document the periosteum's remarkable regenerative capacity, only in the past decade have scientists undertaken mechanistic investigations of periosteum's regenerative potential. Here we outline three presentations from a 2012 Orthopaedic Research Society Workshop which reviewed the current state of the art in molecular, cellular and tissue scale approaches to elucidate the mechanisms underlying the periosteum's regenerative potential and translational therapies as well as engineering solutions inspired by the periosteum's remarkable regenerative capacity. First, we highlight the development of the periosteum and its role in bone repair, noting that the entire population of osteoblasts within periosteum, and at endosteal and trabecular bone surfaces within the bone marrow, derive from the embryonic perichondrium. Secondly, we underscore the role of periosteum derived cells in postnatal bone healing and regeneration; cells of the periosteum contribute more to formation of cartilage and bone within the callus during fracture healing than do cells of the bone marrow or endosteum, which not migrate out of the bone marrow compartment. Furthermore, a current healing paradigm regards the activation, expansion and differentiation of periosteal stem/progenitor cells as an essential step in building a template for subsequent neovascularization, bone formation and remodeling. Thirdly, the periosteum comprises a complex, composite structure, providing a niche for pluripotent cells and a repository for molecular factors that modulate cell behavior. The periosteum's advanced, "smart" material properties change depending on the mechanical, chemical and biological state of the tissue. Understanding periosteum development, progenitor cell-driven initiation of periosteum's endogenous tissue building capacity, as well as the complex structure-function relationships of periosteum as an advanced material are important for harnessing and engineering ersatz materials to mimic the periosteum's remarkable regenerative capacity.

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“…Top-down and bottom-up approaches look to explore the connectivity of biological and cellular components within certain physiological systems, to further model and analyze the progression of disease throughout the body [4]. The ability to image sub-cellular to tissue-organ scale structures is critical in providing an integrated understanding of physiological mechanisms [2,30,31].…”

Section: Discussionmentioning

confidence: 99%

Creating High-Resolution Multiscale Maps of Human Tissue Using Multi-beam SEM

et al. 2016

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Multi-beam scanning electron microscopy (mSEM) enables high-throughput, nano-resolution imaging of macroscopic tissue samples, providing an unprecedented means for structure-function characterization of biological tissues and their cellular inhabitants, seamlessly across multiple length scales. Here we describe computational methods to reconstruct and navigate a multitude of high-resolution mSEM images of the human hip. We calculated cross-correlation shift vectors between overlapping images and used a mass-spring-damper model for optimal global registration. We utilized the Google Maps API to create an interactive map and provide open access to our reconstructed mSEM datasets to both the public and scientific communities via our website www.mechbio.org. The nano- to macro-scale map reveals the tissue’s biological and material constituents. Living inhabitants of the hip bone (e.g. osteocytes) are visible in their local extracellular matrix milieu (comprising collagen and mineral) and embedded in bone’s structural tissue architecture, i.e. the osteonal structures in which layers of mineralized tissue are organized in lamellae around a central blood vessel. Multi-beam SEM and our presented methodology enable an unprecedented, comprehensive understanding of health and disease from the molecular to organ length scale.

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Top down and bottom up engineering of bone

Cited by 48 publications

References 75 publications

Effect of Nanoscale Topography of Titanium Implants on Bone Vessel Network, Osteocytes, and Mineral Densities

Effect of Nanoscale Topography of Titanium Implants on Bone Vessel Network, Osteocytes, and Mineral Densities

Current insights on the regenerative potential of the periosteum: Molecular, cellular, and endogenous engineering approaches

Creating High-Resolution Multiscale Maps of Human Tissue Using Multi-beam SEM

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