2021
DOI: 10.1101/2021.09.20.461107
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Top2a promotes the development of social behavior via PRC2 and H3K27me3

Abstract: Human infants exhibit innate social behaviors at birth, yet little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted in lasting social deficits in zebrafish. In mice, prenatal Top2 inhibition caused behavioral defects related to core symptoms of autism, including impairments in social interaction and communication. Mutation of Top2a in zebrafish caused downregulation of a set of genes highly enriche… Show more

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Cited by 5 publications
(12 citation statements)
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“…Embryonic exposure to valproic acid (VPA) is an established model of autism in rodents 19 and zebrafish 20 . Using a simple zebrafish social preference assay 21 , we observed a clear social deficit phenotype in VPA-treated zebrafish (Supplementary Fig. 6a).…”
Section: Dopamine D3 Receptor Agonists Rescue Social Deficits In a Vpa-induced Autism Modelmentioning
confidence: 97%
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“…Embryonic exposure to valproic acid (VPA) is an established model of autism in rodents 19 and zebrafish 20 . Using a simple zebrafish social preference assay 21 , we observed a clear social deficit phenotype in VPA-treated zebrafish (Supplementary Fig. 6a).…”
Section: Dopamine D3 Receptor Agonists Rescue Social Deficits In a Vpa-induced Autism Modelmentioning
confidence: 97%
“…The drug treated embryos were washed at 3 dpf and transferred to petri dishes containing clean E3 medium. At 5-7 dpf, larvae were transferred into nursery tanks and raised to 21 dpf for behavioral testing of social preference using a 3-chamber assay apparatus 21 . For the D3 agonist rescue experiment, 20 VPA-treated fish were picked into a 25 mm deep 10 cm petri dish containing 30 ml E3 medium.…”
Section: Rescue Of Vpa Fish and Social Preference Testingmentioning
confidence: 99%
“…3) Prey-capture Feeding Assay Prey-capture assays using paramecia were performed as previously reported (Zoodsma et al, 2020). Larval prey capture learning assays were adapted from (Geng et al, 2021). At 5 and 6 dpf, sh in the naïve group were fed sh akes (Hikari USA inc.), while sh in the experienced group were fed Paramecia Caudatum (Carolina Biological Supply).…”
Section: ) Social Behavior Assaymentioning
confidence: 99%
“…Consistent with this nding, wild-type sh at 1 wpf spent approximately equal amounts of time in each zone, indicating no social preference, whereas sh at 3 or 4 wpf spent over half of their time in Zone 4, indicating a strong social preference (Figure 3B). To quantify social preference of individual test sh, we used a social preference index (SPI) (Adapted from (Geng et al, 2021), see Materials and Methods). SPI values closer to +1 indicate a strong social preference, those closer to -1 indicate a social aversion, and those around 0 indicate no social preference.…”
Section: Zebra Sh Lacking Glun2b Are Viablementioning
confidence: 99%
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