Topic use of Annona crassiflora Mart. contributes to wound healing due to the antioxidant and proliferative effects of fibroblasts

Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

“…Only phenolic-rich fractions (ethyl acetate (0.1 and 0.3 µg/mL) and n -butanol (1 µg/mL) fractions) reduced LPS-stimulated IL-6 and NO production. Topical treatment of wounds induced on the back of mice for 7–21 days with an ointment containing 4% of a phenolic-rich fraction from araticum peel was able to attenuate local inflammation by inhibiting MPO and NAG activities that reduce the activation of neutrophils and macrophages in cutaneous wounds [ 58 , 59 , 60 ]. Mice pre-treated orally with a phenolic-rich fraction (ethyl acetate fraction) from araticum peel (30 mg/kg bw) showed a reduced formation of CFA-induced paw edema in the acute phase due to the decrease in MPO activity and leukocyte infiltration in the paw tissue [ 56 ].…”

“…Prado et al [ 23 ] verified that a phenolic-rich extract from araticum seeds promoted keratinocyte (HaCaT) migration, leading to 73% of slot closure at 3.6 µg/mL. Animal trials conducted by de Moura et al [ 58 , 59 , 60 ] showed that topical application of an ointment, containing 4% of a phenolic-rich fraction from araticum peel, on wounds induced on the back of mice, for 7–21 days, accelerated the cutaneous wound closure by reducing local inflammation (decreased neutrophil and macrophage activation, as well as MPO and NAG activities) and oxidative damage (decreased lipid peroxidation while increased CAT activity), stimulating the profibrogenic process (increased number of mast cells and deposition of types I and III collagen fibers in wounds), promoting keratinocyte and fibroblast proliferation and migration (increased MMP-2 and MMP-9 activities), and improving dermis and epidermis organization during healing. This wound healing effect can be attributed to the ability of phenolic compounds present in these extracts/fractions (see Table 1 ) in modulating different biochemical pathways involved in the tissue repair process [ 6 ].…”

Frutos do Cerrado, você conhece?

“…As sementes dos frutos têm sido avaliadas quanto a sua ação antitumoral em ensaios para câncer de pulmão de pequenas células (A549), adenocarcinoma colorretal humano (HT-29) e câncer de mama (MCF-7) e os resultados demonstram a redução da proliferação de linhas celulares tumorais humanas (ARRUDA; PASTORE, 2019). Além da polpa e semente, a casca do fruto tem um potencial anti-inflamatório, e este efeito foi observado na cicatrização de feridas, quando uma pomada contendo bioativos da casca do fruto foi produzida e utilizada para uso tópico (DE MOURA et al, 2022).…”