Topical 0.03% atropine vs. 15% aluminum chloride in treating multiple eccrine hidrocystomas: A randomized single blind controlled study

Abstract

Background:Multiple eccrine hidrocystomas pose a significant treatment challenge due to their facial location and tendency to scar after traditional surgical and other destructive modalities.Aims:To compare two frequently used non-destructive therapeutic modalities.Materials and Methods:Thirty patients with multiple eccrine hidrocystomas were enrolled in the study. They used topical 0.03% Atropine cream and 15% AlCl3 solution on left and right sides of their face randomly for 4 weeks. All the patients were visited before commencing the therapy as well as two and four weeks later by a dermatologist, blinded to the drugs and the number of lesions.Results:Twenty nine patients (25 females, four males) completed the study. The mean reduction in the number of lesions was significantly higher with Atropine cream in comparison with AlCl3 solution, 10.2±7.4 vs. 6.2±5.3 (P < 0.05). There were no recurrences after three months follow-up in both groups.Conclusion:It seems that both Atropine and AlCl3 are useful therapies in eccrine hidrocytomas but the former might be more effective. We think that other randomized clinical trials with larger sample sizes are needed.

Giant Eyelid Eccrine Hidrocystoma: A Case Report

“…Multiple eccrine hidrocystomas have also been successfully treated with topical application of 15% aluminium chloride. Topical 0.03% atropine was found to be just as effective as 15% aluminium chloride in a randomised, single-blind controlled study at reducing the size and number of eccrine hidrocystomas [12]. In addition to these forms of therapy, the underlying cause of the lesion should also be taken into account.…”

Local anticholinergic treatment for multiple eccrine hidrocystomas: report of two cases and literature review

“…The review of relevant articles revealed 55 reported patients with multiple eccrine hidrocystomas treated with topical anticholinergic compounds (Table 1). Two controlled studies were detected; one with atropine sulphate 0.03 % cream versus aluminum chlorine 15 % in 29 patients assessed marked superiority of atropine sulphate (50 % vs. 30 % mean reduction of lesions, P < 0.05) and another with atropine sulphate 1 % versus scopolamine butylbromide 40 % versus ipratropium bromide 1 % in five patients evaluated superiority of ipratropium bromide (73 % vs. 70 % vs. 98 %, control 0 % median improvement, P = 0.021) [5,19]. Side effects of atropine were concentration-dependent (0.03-1 % solution, cream or ointment), including blurred vision, dry skin, mydriasis and nausea.…”

Lokale anticholinerge Therapie multipler ekkriner Hidrozystome: Bericht über zwei Fälle und Literaturübersicht

“…Die Durchsicht relevanter Artikel hat 55 Patienten mit multiplen ekkrinen Hidrozystomen berichtet wurde nachgewiesen, die mit topischen anticholinergen Substanzen behandelt wurden (Tabelle 1). Es existieren zwei kontrollierte Studien, eine mit Atropinsulfat-Creme 0,03 % versus Aluminiumchlorid 15 % bei 29 Patienten, die eine deutliche Überlegenheit von Atropinsulfat (50 % vs. 30 % mittlere Reduktion der Läsionen, P < 0,05) zeigte, und eine mit Atropinsulfat 1 % versus Scopolaminbutylbromid 40 % oder Ipratropiumbromid 1 % bei fünf Patienten, die eine Überlegenheit von Ipratropiumbromid feststellte (73 % vs. 70 % vs. 98 %, Kontrolle 0 % mediane Verbesserung, P = 0,021) [5,19]. Die Nebenwirkungen von Atropin waren konzentrationsabhängig (0,03-1%ige Lösung, Creme oder Salbe), einschließlich verschwommenes Sehen, trockene Haut, Mydriasis und Übelkeit.…”