Topical 15% Resorcinol Is Associated with High Treatment Satisfaction in Patients with Mild to Moderate Hidradenitis Suppurativa

Abstract

<b><i>Background:</i></b> Topical 15% resorcinol is commonly used in clinical practice for the treatment of nodules and abscesses in patients with hidradenitis suppurativa (HS). It has been shown to be clinically effective in some small studies, but data on satisfaction perceived by patients are lacking. The Treatment Satisfaction Questionnaire for Medication (TSQM) version 1.4 is a validated measure of patient satisfaction, evaluating four domains: effectiveness, side effects, convenience, and global satisfaction. Our objective was to obtain data from HS patients regarding resorcinol treatment satisfaction and its relationship with clinical and epidemiological variables. <b><i>Methods:</i></b> We performed a cross-sectional study providing TSQM version 1.4 questionnaires to HS patients who had been prescribed topical resorcinol during the previous 24 months. <b><i>Results:</i></b> Ninety-two patients answered the questionnaire. Eighty-five out of 92 (92.4%) were Hurley II and 7 Hurley I. The mean total score was 317.5 out of 400 (71.0 points in effectiveness, 93.6 in side effects, 79.3 in convenience, and 73.2 in global satisfaction). Total score was higher in men than in women (329.7 vs. 311.6, <i>p</i> = 0.026) and higher scores on convenience were seen in patients who were not overweight or obese (86.9 vs. 77.1, <i>p</i> = 0.016). Most patients (65, 70.6%) denied having any side effect. 78 (84.8%) of the patients would recommend the treatment. <b><i>Conclusion:</i></b> The results of this study suggest that HS patients treated with resorcinol 15% are very satisfied with this treatment.

Resorcinol 10% as a Promising Therapeutic Option for Mild Hidradenitis Suppurativa: A Prospective, Randomized, Open Study

“…Resorcinol is an organic phenol derivate, used mainly because of its keratolytic properties at the level of the follicular infundibulum [5]. Given the pivotal role of follicular occlusion in the pathogenesis of HS, resorcinol has emerged as an important, nonantibiotic topical therapy for HS [5, 6]. In the literature, topical resorcinol 15% has been used in patients with Hurley stage I or II HS [4, 5].…”

“…Recent studies have shown the efficacy and safety of 15% topical resorcinol cream [4, 6]. To the best of our knowledge, the efficacy of 10% topical resorcinol cream has not yet been studied.…”

S2k-Leitlinie zur Therapie der Hidradenitis suppurativa/Acne inversa (ICD-10-Code: L73.2)

“…Eine weitere spanische Querschnittstudie untersuchte die Zufriedenheit von 92 Patienten mit Hurley-Grad I-II, deren Knoten und Abszessen mit Resorcinol 15 % behandelt wurden. Männer und nicht-adipöse Patienten zeigten sich mit der Therapie zufrieden, 85 % der behandelten Patienten würden die Therapie weiterempfehlen [314]. Die häufigsten Nebenwirkungen sind ein irritatives oder seltener allergisches Kontaktekzem und eine bräunliche Verfärbung der Haut [1,184].…”

A case of recurrent painful boils

“…Compounded 15% topical resorcinol is a useful adjunct and acts as a drawing agent for active boils. 10 Many patients also benefit from daily topical antibiotic therapy (eg clindamycin lotion). 8 Some women may also report improvement with anti-androgenic oral contraceptives.…”