Topical 5‐aminolaevulinic acid photodynamic therapy for cutaneous lesions: outcome and comparison of light sources

Clark, Colin; Bryden, Alyson; Dawe, Robert; Moseley, Harry; Ferguson, J.; Ibbotson, S.H.

doi:10.1034/j.1600-0781.2003.00024.x

Cited by 149 publications

(137 citation statements)

References 33 publications

(60 reference statements)

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“…57,58 After local reactions have healed (mostly erythema and crusting), cosmesis is generally excellent. 59,60 PDT systems offer reasonable options for AKs disseminated over large areas. In more advanced AKs, curettage is generally required before PDT to remove hyperkeratotic tissue.…”

Section: Pdt and Daylight Pdtmentioning

confidence: 99%

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

et al. 2015

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Background Actinic keratosis (AK) and cheilitis (AC) are lesions that develop on photodamaged skin and may progress to form invasive squamous cell carcinomas (SCCs). Objective To provide guidance to Canadian health care practitioners regarding management of AKs and ACs. Methods Literature searches and development of graded recommendations were carried out as discussed in the accompanying introduction (chapter 1 of the NMSC guidelines). Results Treatment of AKs allows for secondary prevention of skin cancer in sun-damaged skin. Because it is impossible to predict whether a given AK will regress, persist, or progress, AKs should ideally be treated. This chapter discusses options for the management of AKs and ACs. Conclusions Treatment options include surgical removal, topical treatment, and photodynamic therapy. Combined modalities may be used in case of inadequate response. AKs are particularly common following the longterm immunosuppression in organ transplant patients, who should be monitored frequently to identify emerging lesions that require surgery.

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Section: Pdt and Daylight Pdtmentioning

confidence: 99%

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

et al. 2015

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“…The ability of '882 to specifically photosensitize Gram-positive bacteria circumvents the nonspecific nature of ALA-PDT, which has limited the value of ALA-PDT for the treatment of infectious diseases (6,49,50). Furthermore, this provides proof-of-concept that activation of bacterial porphyrin production through specific activation of CgoX is a viable therapeutic strategy that could be adapted to Gram-negative bacteria and other infectious diseases (6,16,47).…”

Section: Discussionmentioning

confidence: 96%

Antibacterial photosensitization through activation of coproporphyrinogen oxidase

Surdel

Horvath

Lojek

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Gram-positive bacteria cause the majority of skin and soft tissue infections (SSTIs), resulting in the most common reason for clinic visits in the United States. Recently, it was discovered that Gram-positive pathogens use a unique heme biosynthesis pathway, which implicates this pathway as a target for development of antibacterial therapies. We report here the identification of a small-molecule activator of coproporphyrinogen oxidase (CgoX) from Gram-positive bacteria, an enzyme essential for heme biosynthesis. Activation of CgoX induces accumulation of coproporphyrin III and leads to photosensitization of Gram-positive pathogens. In combination with light, CgoX activation reduces bacterial burden in murine models of SSTI. Thus, small-molecule activation of CgoX represents an effective strategy for the development of light-based antimicrobial therapies.

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“…Here incoherent light sources are preferred, either lamps or light-emitting diodes (LEDs) which match the absorption maxima of the ALA-or MAL-induced porphyrins [25,27,28]. Using broad-spectrum red light (580-700 nm), a light dose of 100-150 J/cm 2 (100-200 mW/ cm 2 ) is essential for tissue damage.…”

Section: Light Sources and Action Mechanismmentioning

confidence: 99%

“…Using broad-spectrum red light (580-700 nm), a light dose of 100-150 J/cm 2 (100-200 mW/ cm 2 ) is essential for tissue damage. The light intensity should not exceed 200 mW/cm 2 in order to avoid hyperthermic side effects [27]. After a photosensitizer has been activated with light of appropriate wavelength, it comes to the generation of reactive oxygen species (ROS), in particular singlet oxygen.…”

Section: Light Sources and Action Mechanismmentioning

confidence: 99%

Photodynamic Therapy and Skin Cancer

Papakonstantinou¹,

Löhr²,

Raap³

2018

Dermatologic Surgery and Procedures

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Non-melanoma skin cancer (NMSC) is the most common type of cancer among white skin individuals worldwide with an increasing incidence over the last years. NMSC is mostly treated with surgical or non-invasive methods such as cryotherapy or topical chemotherapeutics. Over the last years, there has been a rapidly growing interest in the use of photodynamic therapy (PDT) which is a well-tolerated, safe and effective alternative treatment option. PDT involves a photosensitizer, a light source and tissue oxygen and is based on a photo-oxidation reaction in the target tissue which results to a selective destruction of the cancer cells. PDT has been approved for treatment of actinic keratosis, Bowen's disease and basal cell carcinoma in Europe. Off-label uses include treatment of invasive squamous cell carcinoma, cutaneous T-cell lymphoma, Kaposi's sarcoma, Paget's disease and prevention of recurrence of squamous cell carcinoma in organ-transplant recipients. Also combination of PDT with other treatment options such as cryotherapy, surgery and topical therapies has been reported with improved efficacy, tolerability and long-term results. Development of novel photosensitizers and light sources together with targeted delivery systems will increase specificity, efficiency and treatment field of PDT in the future. This chapter aims to give the reader an overview of the important applications of PDT, including indications, approved treatments, advantages and disadvantages of this method such as future trends.

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Topical 5‐aminolaevulinic acid photodynamic therapy for cutaneous lesions: outcome and comparison of light sources

Abstract: Topical ALA-PDT is effective for BD, sBCC and AK and has been an invaluable addition to our dermatology service. Efficacy is similar for broadband and laser light sources, although treatment at higher surface irradiance may be painful, and excellent cosmetic results can be achieved.

Cited by 149 publications

References 33 publications

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

Antibacterial photosensitization through activation of coproporphyrinogen oxidase

Photodynamic Therapy and Skin Cancer

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