Topical 5 Fluorouracil and Microneedling in the Treatment of Planter Warts: Randomized Comparative Trial

Abstract

Background: Warts are benign proliferations of skin and mucosa that result from infection with human papilloma virus (HPV) which are double stranded deoxyribonucleic acid (DNA) viruses that replicate inside the nucleus. Infection with HPV may be clinical, subclinical, or latent.Objective: To compare the efficacy and safety of intralesional 5-FU solution and 5-FU solution using micro needling technique in the treatment of planter warts. Patients and methods:Our study was carried out on 60 patients complaining of planter warts divided into two equal groups: A and B from June 2020 to Janurary 2021, Group A: with planter warts received intralesional 5-FU solution every two weeks, and Group B:with planter warts received 5-FU solution using a micro needling pen type device every two weeks, for maximum period of six sessions or complete absence of the lesion. Patients were selected from out-